Navigation Links
New Clues to Treating an Aggressive Breast Cancer
Date:5/18/2010

Findings may lead to earlier detection and personalized therapy, researchers say

TUESDAY, May 18 (HealthDay News) --A specific grouping of three markers on the surface of breast cancer cells has been linked to a particularly aggressive, but relatively rare form of cancer called "estrogen receptor-negative" cancer, new research reveals.

The finding is considered to be preliminary but the identification of these markers -- labelled XIC -- could be important because this form of cancer is particularly difficult to treat, the study team notes.

"We are excited but cautious at the prospect that the presence of the XIC markers on [these types of] breast cancer cells may present a selective target for early detection imaging and for personalized therapy," Barbara K. Vonderhaar, scientist emeritus of the Mammary Biology and Tumorigenesis Laboratory at the National Cancer Institute, explained in a news release.

Vonderhaar and her colleagues report the finding in the May 18th online issue of Cancer Research.

No specific therapies exist that can directly target this type of tumor, the authors note. That means the only means of treatment currently available is generalized chemotherapy, which can kill healthy cells as well as tumor cells and thereby render the option intolerable for some patients.

Vonderhaar and her colleagues were able to isolate the XIC marker cells by testing human breast cancer cells taken from four different patients. They observed that such cells had the ability to form tumors after being injected into the mammary glands of immune-compromised mice.

The research team found that estrogen receptor-negative cancer was present when the three particular markers they uncovered were all present simultaneously.

Down the road, the authors hope to determine whether or not the same XIC marker combination might also similarly identify the more easily treatable estrogen receptor-positive form of breast cancer.

More information

For more on breast cancer, visit Breast Cancer.org.



-- Alan Mozes



SOURCE: Cancer Research, May 14, 2010, news release


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Pigs Yield Clues to Cystic Fibrosis-Related Lung Disease
2. New Clues Shed Light on Sperm Function, Male Fertility
3. Ovarian cancer study offers vital clues for new therapies
4. Change in breast density over time provides clues about breast cancer risk
5. Lab that probes genetic clues to disease is poised for major expansion
6. More Clues Emerge on How HIV Infects Women
7. Scientists Find Clues to How the Body Fights Off HIV
8. New Clues to Pregnancy-Associated Breast Cancer
9. Clues Found to How Different Flu Vaccines Work
10. Clues to pregnancy-associated breast cancer found
11. Blood Gives Clues to Executive Thinking Problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/17/2017)... ... February 17, 2017 , ... For the first ... solution to the exhibit floor for the 2017 HIMSS Conference & Exhibition ... Feb. 19–23, 2017, more than 40,000 healthcare industry professionals are expected at the ...
(Date:2/17/2017)... ... February 17, 2017 , ... Empowering each person's mental ... for each and every seminar, session and class she offers. At the ... tools which help energize creativity, focus mental functions, enhance athletic focus and skill ...
(Date:2/17/2017)... ... February 17, 2017 , ... Qualis Health, ... finalist in the 8th Annual DecisionHealth Platinum Awards in recognition of its innovative ... work is recognized across multiple award categories, highlighting four of the organization’s current ...
(Date:2/17/2017)... (PRWEB) , ... February 17, 2017 , ... ... by fall 2017 season , Trinity Health and the U.S. Soccer Foundation announced ... Success program in underserved communities. Soccer for Success, the Foundation’s soccer mentoring program, ...
(Date:2/17/2017)... ... February 17, 2017 , ... Pharmica Consulting ... on all facets of clinical trial planning and management. Pharmica discussed the importance ... more. In addition, attendees stopping by Pharmica’s booth were able to demo its ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... DUBLIN , Feb. 17, 2017 ... ("Theravance Biopharma" or the "Company") today announced the ... novel, potent, and orally administered pan-Janus kinase (JAK) ... 12 th Congress of the European Crohn,s ... the Company reported further data from its completed ...
(Date:2/17/2017)... 2017 Research and Markets has announced the addition ... report to their offering. ... report provides separate comprehensive analytics for the US, Canada ... Asia-Pacific , and Rest of World. Annual estimates and forecasts ... analysis is provided for these markets. Market data and analytics are derived ...
(Date:2/17/2017)... NEW YORK , Feb. 17, 2017   ... other side effects allegedly associated with use of the ... Philadelphia Court of Common Pleas, ... a mass tort program. According to a notice posted ... scheduled to convene a meeting on March 9, 2017 ...
Breaking Medicine Technology: