Navigation Links
New Clues to Treating an Aggressive Breast Cancer
Date:5/18/2010

Findings may lead to earlier detection and personalized therapy, researchers say

TUESDAY, May 18 (HealthDay News) --A specific grouping of three markers on the surface of breast cancer cells has been linked to a particularly aggressive, but relatively rare form of cancer called "estrogen receptor-negative" cancer, new research reveals.

The finding is considered to be preliminary but the identification of these markers -- labelled XIC -- could be important because this form of cancer is particularly difficult to treat, the study team notes.

"We are excited but cautious at the prospect that the presence of the XIC markers on [these types of] breast cancer cells may present a selective target for early detection imaging and for personalized therapy," Barbara K. Vonderhaar, scientist emeritus of the Mammary Biology and Tumorigenesis Laboratory at the National Cancer Institute, explained in a news release.

Vonderhaar and her colleagues report the finding in the May 18th online issue of Cancer Research.

No specific therapies exist that can directly target this type of tumor, the authors note. That means the only means of treatment currently available is generalized chemotherapy, which can kill healthy cells as well as tumor cells and thereby render the option intolerable for some patients.

Vonderhaar and her colleagues were able to isolate the XIC marker cells by testing human breast cancer cells taken from four different patients. They observed that such cells had the ability to form tumors after being injected into the mammary glands of immune-compromised mice.

The research team found that estrogen receptor-negative cancer was present when the three particular markers they uncovered were all present simultaneously.

Down the road, the authors hope to determine whether or not the same XIC marker combination might also similarly identify the more easily treatable estrogen receptor-positive form of breast cancer.

More information

For more on breast cancer, visit Breast Cancer.org.



-- Alan Mozes



SOURCE: Cancer Research, May 14, 2010, news release


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Pigs Yield Clues to Cystic Fibrosis-Related Lung Disease
2. New Clues Shed Light on Sperm Function, Male Fertility
3. Ovarian cancer study offers vital clues for new therapies
4. Change in breast density over time provides clues about breast cancer risk
5. Lab that probes genetic clues to disease is poised for major expansion
6. More Clues Emerge on How HIV Infects Women
7. Scientists Find Clues to How the Body Fights Off HIV
8. New Clues to Pregnancy-Associated Breast Cancer
9. Clues Found to How Different Flu Vaccines Work
10. Clues to pregnancy-associated breast cancer found
11. Blood Gives Clues to Executive Thinking Problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... CDRH Enforcement Trends: , Back to the ... , As Winston Churchill said, “Those who don’t learn from history are ... what to expect when they come knocking this year. But that takes time. , ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Each year, the ... be held in Anaheim, CA at the Anaheim Convention Center. Almost 10,000 physical therapists ... new therapy products in action, learn more about their chosen field and network with ...
(Date:2/12/2016)... ... 12, 2016 , ... Coco Libre, the maker of coconut water beverages with ... Style Lounge Event. Coco Libre will offer musicians and celebrities the company’s signature Organic ... The invitation-only gifting suite, held this year at the W Hollywood Hotel, has become ...
(Date:2/12/2016)... ... February 12, 2016 , ... The ThedaCare ... San Francisco General Hospital on April 5-7. The series is a multi-day, multi-workshop ... habits. The workshops cover a broad range of topics, including coaching skills, the ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Every winter, someone ... This winter the West Penn Burn Center, part of the Allegheny Health ... to bring you the “Space Heaters Need Space” campaign. , “Space ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... 2016 /PRNewswire/ - Demers Ambulances announces its first delivery in the ... Okaloosa County Emergency Medical Services (EMS) consisting of ... LT2 van. Quality Emergency Vehicles in Lecanto, FL ... sale.  This is the latest in Demers, ongoing expansion of ... at Demers. --> Benoit LaFortune , Executive Vice ...
(Date:2/12/2016)... HOUSTON , Feb. 12, 2016  Memorial Hermann ... center Dwight Howard to bring a one-of-a-kind ... Hospital . Using cutting-edge technologies such as 360-degree video ... kids both virtually, then literally – giving the patients ... – and it was all caught on video ...
(Date:2/12/2016)... 2016  Aralez Pharmaceuticals Inc. (Nasdaq: ARLZ ) ... will ring the Nasdaq Closing Bell at the Nasdaq ... at 4:00 p.m. ET on Tuesday, February 16, ... Adrian Adams , will perform the honorary bell ... p.m. ET.  A live webcast will be available at: ...
Breaking Medicine Technology: