Navigation Links
New Clues to Link Between Fatty Diet, Colon Cancer
Date:3/16/2012

THURSDAY, March 15 (HealthDay News) -- Researchers say they've discovered clues about how a fatty diet increases the risk of colon cancer.

"There have always been questions about why things like diet and obesity are independent risk factors for colon cancer. This study suggests how and why high-fat diets are linked to colon cancer," lead author Carmen Sapienza, a professor of pathology in Temple University's Fels Institute for Cancer Research and Molecular Biology, said in a university news release.

He and his colleagues examined healthy colon tissue from colon cancer patients and found that epigenetic marks on genes involved in breaking down carbohydrates, fats and amino acids -- which are all common in a fatty Western diet -- seem to have been retrained.

Epigenetic marks are chemical modifications that act as on/off switches for many genes, according to the release.

"These foods are changing the methylation patterns on a person's insulin genes so that they express differently, pumping out more insulin than the body requires," Sapienza explained. "In people that have colon cancer, their glucose metabolic pathways and insulin-signaling pathways are running at completely different levels than people who don't have colon cancer."

Cancer cells "love" insulin and studies have shown that tumors feed off insulin, Sapienza noted.

Most cases of colon cancer occur in people 50 and older, and it is unclear when these genetic changes begin. If such changes can be detected in other healthy tissues in the body, it might be possible to use blood or saliva tests to determine a person's colon cancer risk or diagnose the disease, Sapienza suggested.

The study was published in the March issue of the journal Cancer Prevention Research.

More information

The American Cancer Society has more about colorectal cancer.

-- Robert Preidt

SOURCE: Temple University, news release, March 7, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Tiny fruit fly could offer big clues in fight against obesity, researcher says
2. Chickens May Provide Clues to Color Vision
3. New clues found linking larger animals to colder climates
4. New Clues to Lupus Link With Heart Disease
5. Blood Gives Clues to Executive Thinking Problems
6. Clues to pregnancy-associated breast cancer found
7. Clues Found to How Different Flu Vaccines Work
8. New Clues to Pregnancy-Associated Breast Cancer
9. Scientists Find Clues to How the Body Fights Off HIV
10. More Clues Emerge on How HIV Infects Women
11. Lab that probes genetic clues to disease is poised for major expansion
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Clues to Link Between Fatty Diet, Colon Cancer
(Date:2/10/2016)... SAN FRANCISCO, Calif. (PRWEB) , ... February 10, 2016 , ... ... category: Best Water Brand. There were three leading bottled water brand owners that topped ... edge services that enhance connectivity and optimize conversion. The premier brand was Tibet 5100, ...
(Date:2/10/2016)... ... February 10, 2016 , ... United Benefit ... as the latest addition to its growing list of Partner Firms. S.S. ... Southeast, from Orlando to Huntsville and in between. , Harnessing the experience and ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... change in their patients. Research shows that the Goal Attainment Scale (GAS) captures ... overcome this challenge and learn more about the Goal Attainment Scale, Education Resources ...
(Date:2/10/2016)... , ... February 10, 2016 , ... ... biocompatible columns and accessories. These PEEK-lined stainless steel (PLS) columns combine the strength ... solution that ensures the integrity of biological samples while operating at ultra-high pressures ...
(Date:2/10/2016)... ... February 10, 2016 , ... Anxiety of older Americans over steep cost ... Part D a decade ago, according to The Senior Citizens League (TSCL). ... they are coping with rapidly rising costs. “The implications are chilling, particularly for ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... Fla. , Feb. 10, 2016 CSI ... today with the launch of the Specialty Pharmacy Podcast. ... an industry-first, aimed at providing real-world education, discussion and ... --> --> The ... and CEO of CSI Specialty Group Suzette DiMascio, CHE, ...
(Date:2/10/2016)... YORK , Feb. 10, 2016 Immune ... biopharmaceutical company, announced today that it has filed a ... Leukemia and other cancers. --> ... treating cancer by administration of Ceplene (histamine dihydrochloride) in ... provides methods of predicting the efficacy of Ceplene and ...
(Date:2/10/2016)... Feb. 10, 2016  The ALS Association, in partnership with ... Challenge to generate a biomarker to track TDP43 aggregation. The ... to a $1 million investment. --> ... that affects nerve cells in the brain and the spinal ... and control muscle movement, which often leads to total paralysis ...
Breaking Medicine Technology: