Navigation Links
New Clues to How Alcohol May Boost Cancer Risk
Date:8/22/2012

WEDNESDAY, Aug. 22 (HealthDay News) -- A new study provides insight on how alcohol may increase cancer risk. When the body metabolizes -- or breaks down -- alcohol, a substance called acetaldehyde is formed, which can cause DNA damage, researchers say.

Acetaldehyde's chemical makeup is similar to the known carcinogen formaldehyde, according to the researchers.

"We now have the first evidence from living human volunteers that acetaldehyde formed after alcohol consumption damages DNA dramatically," study leader Silvia Balbo, a research associate at the University of Minnesota in Minneapolis, said in an American Chemical Society news release.

Acetaldehyde attaches to DNA, interfering "with DNA activity in a way [that is] linked to an increased risk of cancer," Balbo explained. The bits of DNA attached to cancer-causing chemicals are known as adducts.

For the study, the researchers gave 10 volunteers increasing doses of vodka once a week for three weeks. They found that levels of DNA adducts increased up to 100 times in participants' oral cells within hours after each dose. These levels dropped about 24 hours later.

The study authors pointed out, however, that most people who drink socially do not develop cancer because they are equipped with a natural repair system. Most people have an enzyme known as alcohol dehydrogenase, which converts acetaldehyde to a harmless substance known as acetate.

But certain people are not able to convert acetaldehyde to acetate because they have a variant of the alcohol dehydrogenase gene, the researchers noted. As a result, they are more likely to develop esophageal cancer from drinking alcohol. About 30 percent of people of Asian descent have the variant. Native Americans and Native Alaskans also have a deficiency in the production of this enzyme, they said.

The findings were scheduled to be presented Wednesday at the American Chemical Society's annual meeting in Philadelphia. The data and conclusions of research presented at medical meetings should be viewed as preliminary until published in a peer-reviewed journal.

More information

The U.S. Centers for Disease Control and Prevention has more about alcohol and public health.

-- Mary Elizabeth Dallas

SOURCE: American Chemical Society, news release, Aug. 22, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Genetic Studies Give Clues to Tourette Syndrome, OCD
2. Why Women Outlive Men: Fruit Flies Give Clues
3. New Clues to How HIV Infects Bodys Cells
4. Scientists discover new clues explaining tendon injury
5. Fossilized Teeth Hold Clues to Early Human Species Diet
6. Researchers at IRB Barcelona uncover new clues about the origin of cancer
7. Amazon Tribe Gives Clues to Heart-Healthy Lifestyles
8. New Clues to the Evolution of the Human Brain
9. Geisel researchers sift through junk to find colorectal cancer clues
10. Clues to Slacker Behavior Found in Brain, Study Says
11. Research yields new clues to how brain cancer cells migrate and invade
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... Every winter, someone is killed, injured or ... West Penn Burn Center, part of the Allegheny Health Network, has partnered with ... the “Space Heaters Need Space” campaign. , “Space Heaters Need Space” aims ...
(Date:2/12/2016)... ... February 12, 2016 , ... AssureVest Insurance Group, a locally ... a charity drive that will raise funds earmarked to purchase computers and software for ... School. , “My school is in a low-income area and has more than 60 ...
(Date:2/12/2016)... ... February 12, 2016 , ... Vail knee specialist ... Leaders to Know in 2016 . The list consists of physicians establishing, leading and ... establish this list. , An Ambulatory Surgery Center, also known as an ASC, ...
(Date:2/12/2016)... PA (PRWEB) , ... February 12, 2016 , ... ... families of the Pittsburgh metro area, celebrates the beginning of the latest charity ... children develop social skills through art. Donations to this worthy cause are currently ...
(Date:2/12/2016)... MIAMI, FLA (PRWEB) , ... February 12, 2016 , ... ... free dental implants to their Miami dental office. Beginning in January, Miami Dental ... traditional titanium. Miami Dental Specialists are the first office to be chosen by the ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)...  Clinical Affairs leaders at pharmaceutical organizations are looking to either ... world. While some companies have conducted a significant number of clinical ... countries such as India and ... India are now requiring local clinical trials ... --> China and India ...
(Date:2/12/2016)... 12, 2016 Hypermarcas S.A. ("Hypermarcas") today ... offer (the "Tender Offer") to purchase any and ... amount of its 6.500% Senior Notes due 2021 ... USP5246AAF05) (the "Notes"). In connection with the Tender ... consents (the "Consents") of the holders of the ...
(Date:2/12/2016)... , Feb. 12, 2016 /PRNewswire/ - Demers Ambulances announces its ... to Okaloosa County Emergency Medical ... III ambulances and one LT2 van. Quality Emergency Vehicles in ... is responsible for the sale.  This is the latest in ... , Executive Vice President at Demers. --> Benoit ...
Breaking Medicine Technology: