Navigation Links
New Clues to How Alcohol May Boost Cancer Risk
Date:8/22/2012

WEDNESDAY, Aug. 22 (HealthDay News) -- A new study provides insight on how alcohol may increase cancer risk. When the body metabolizes -- or breaks down -- alcohol, a substance called acetaldehyde is formed, which can cause DNA damage, researchers say.

Acetaldehyde's chemical makeup is similar to the known carcinogen formaldehyde, according to the researchers.

"We now have the first evidence from living human volunteers that acetaldehyde formed after alcohol consumption damages DNA dramatically," study leader Silvia Balbo, a research associate at the University of Minnesota in Minneapolis, said in an American Chemical Society news release.

Acetaldehyde attaches to DNA, interfering "with DNA activity in a way [that is] linked to an increased risk of cancer," Balbo explained. The bits of DNA attached to cancer-causing chemicals are known as adducts.

For the study, the researchers gave 10 volunteers increasing doses of vodka once a week for three weeks. They found that levels of DNA adducts increased up to 100 times in participants' oral cells within hours after each dose. These levels dropped about 24 hours later.

The study authors pointed out, however, that most people who drink socially do not develop cancer because they are equipped with a natural repair system. Most people have an enzyme known as alcohol dehydrogenase, which converts acetaldehyde to a harmless substance known as acetate.

But certain people are not able to convert acetaldehyde to acetate because they have a variant of the alcohol dehydrogenase gene, the researchers noted. As a result, they are more likely to develop esophageal cancer from drinking alcohol. About 30 percent of people of Asian descent have the variant. Native Americans and Native Alaskans also have a deficiency in the production of this enzyme, they said.

The findings were scheduled to be presented Wednesday at the American Chemical Society's annual meeting in Philadelphia. The data and conclusions of research presented at medical meetings should be viewed as preliminary until published in a peer-reviewed journal.

More information

The U.S. Centers for Disease Control and Prevention has more about alcohol and public health.

-- Mary Elizabeth Dallas

SOURCE: American Chemical Society, news release, Aug. 22, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Genetic Studies Give Clues to Tourette Syndrome, OCD
2. Why Women Outlive Men: Fruit Flies Give Clues
3. New Clues to How HIV Infects Bodys Cells
4. Scientists discover new clues explaining tendon injury
5. Fossilized Teeth Hold Clues to Early Human Species Diet
6. Researchers at IRB Barcelona uncover new clues about the origin of cancer
7. Amazon Tribe Gives Clues to Heart-Healthy Lifestyles
8. New Clues to the Evolution of the Human Brain
9. Geisel researchers sift through junk to find colorectal cancer clues
10. Clues to Slacker Behavior Found in Brain, Study Says
11. Research yields new clues to how brain cancer cells migrate and invade
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
(Date:6/24/2016)... ... ... Comfort Keepers® of San Diego, CA is excited to announce they are ... drive cancer patients to and from their cancer treatments. Comfort Keepers provides quality ... and ongoing independence. Getting to and from medical treatments is one of the ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented ... in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, ...
(Date:6/24/2016)... ... 24, 2016 , ... Strategic Capital Partners, LLC (SCP) in ... investment capital for emerging technology companies. SCP has delivered investment events and ... more than a million dollars of capital investment for five companies. ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... pluripotent stem (iPS) cells and other difficult to transfect cells, announces its launch ... PluriQ™ G9™ Gene Editing System is a complete system for culturing ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Belgium , June 24, 2016 /PRNewswire/ ... announced the appointment of Dr. Edward Futcher ... a Non-Executive Director, effective June 23, 2016.Dr. Futcher ... and Nominations and Governance Committees.  As a non-executive ... provide independent expertise and strategic counsel to VolitionRx ...
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... - Forecast to 2022" report to their offering. ... to date financial data derived from varied research sources to ... potential impact on the market during the next five years, ... of sub markets, regional and country level analysis. The report ...
Breaking Medicine Technology: