Navigation Links
New Class of Drugs May Fight Alzheimer's

Cousin of some NSAIDS, it could prevent buildup of plaque in the brain, study says

WEDNESDAY, June 11 (HealthDay News) -- A class of drugs called gamma-secretase modulators shows potential for treating Alzheimer's disease, a new study suggests.

A hallmark of Alzheimer's is so-called amyloid plaque, which develops tangles in the brain. The gamma-secretase modulators reduce the production of long pieces of amyloid beta protein that stick together and form clumps. At the same time, the drugs increase the production of shorter amyloid beta that blocks longer amyloid beta from sticking together, the researchers explained.

"We have discovered a novel mechanism of action for a class of drugs that are currently being tested as Alzheimer's disease therapeutics," said lead researcher Dr. Todd E. Golde, an associate professor at the Mayo Clinic Department of Neuroscience, in Jacksonville, Fla.

These new drugs don't work in the same way that many other drugs do, Golde said. "Sometimes we think of drugs as magic bullets targeting a single entity, but this drug, by the way it works, could have three consequences that could have a benefit for Alzheimer's disease," he said.

While the new compounds decrease the production of long chains of amyloid beta, Golde said, "Surprisingly, they increase the presence of shorter chains of amyloid beta, which we think actually prevents the accumulation of longer chains of amyloid beta."

"In a short form, amyloid beta is harmless as far as we know," he added. "So you sort of get three bangs for your buck."

"This finding could tell us how drugs for Alzheimer's disease already in clinical trials may be working," Golde said. One of the modulator drugs, tarenflurbil (Flurizan), was in a just-completed phase III clinical trial, and the results should be available this summer, he said.

The latest findings are published in the June 12 edition of Nature.

One expert thinks the new research could produce a drug that could fight the development of amyloid plaque in two ways.

"This is interesting and unexpected," said Dr. Sam Gandy, chairman of the Alzheimer's Association's National Medical and Scientific Advisory Council. "This suggests that it might be possible to design or identify compounds that both modulate generation of amyloid beta and at the same time modulate accumulation of amyloid beta."

Until now, anti-amyloid drugs have fallen into three broad classes: immunotherapies, anti-aggregation compounds, and secretase modulators, Gandy said. "The new work suggests that there exist single drugs that possess both of the latter two activities, thereby supplying an anti-amyloid double whammy," he said.

Another expert thinks this avenue of attack on amyloid plaque looks promising.

"Chronic intake of NSAIDs like ibuprofen appears to reduce the risk of Alzheimer's," said Greg M. Cole, associate director of the Alzheimer's Disease Research Center at UCLA David Geffen School of Medicine.

"A subset of NSAIDs that the authors call gamma-secretase modulators appears to reduce the accumulation of the stickiest form of beta amyloid protein that is believed to aggregate and cause the disease," Cole said. "This means that the known protective NSAIDs may be a double threat against Alzheimer's and help protect against it if they are taken early for prevention."

More information

For more on Alzheimer's disease, visit the Alzheimer's Association.

SOURCES: Todd E. Golde M.D., Ph.D., associate professor, Department of Neuroscience, Mayo Clinic, Jacksonville, Fla.; Sam Gandy, M.D., chairman, Alzheimer's Association National Medical and Scientific Advisory Council, Chicago; Greg M. Cole, Ph.D., neuroscientist, Greater Los Angeles VA Healthcare System, and associate director, Alzheimer's Disease Research Center, UCLA David Geffen School of Medicine; June 12, 2008, Nature

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Kingfisher Healthcare (KFH) Achieves World Class Quality Platform
2. ADDA Kicks Off AD/HD Awareness Campaign with Four Regional Conferences Beginning Sept. 29 and Series of Fall Teleclasses
3. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
4. First Circuit Court of Appeals Rules Against Philip Morris in Lights Class Action
5. Theater Classes Help Docs Bedside Manners
6. Tarpinian: Misclassification is Theft
7. New class of RNA molecules may be important in human cancer
8. Instrumentation Laboratory Named Top of Class by Respiratory Care Managers
9. Consumer Group: Hillary Clintons Mandatory Health Insurance Purchase Plan is an Act of War on the Middle Class Family That Cant Afford $12k Policy
10. SATELLITE BROADCAST: Consumer Group Says Hillary Clintons Mandatory Health Insurance Plan is an Act of War on the Middle Class that Cant Afford $12k Policy
11. Law Offices of Howard G. Smith Announces Class Action Lawsuit Against LCA-Vision Inc.
Post Your Comments:
Related Image:
New Class of Drugs May Fight Alzheimer's
(Date:11/25/2015)... ... ... “While riding the bus, I saw a passenger in a wheelchair drenched from ... a convenient and comfortable way to protect them from bad weather, so I invented ... during cold or inclement weather. In doing so, it ensures that the user remains ...
(Date:11/25/2015)... ... 2015 , ... Privately owned Contract Development and Manufacturing Organization ... current state of the art research, development and manufacturing facility outside of Fort ... capacity as well as to support its clients’ growing research and development and ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... Students and ... were awarded to winners of the Create Real Impact awards. California Casualty ... to help stem the tide of distracted and reckless driving, the number one killer ...
(Date:11/24/2015)... ... November 24, 2015 , ... New patients who wish to seek treatment ... dental implants at her Mississauga, ON practice. Dr. Williams has been providing dental ... dental implants. , Missing teeth can lead to a variety of complications if ...
(Date:11/24/2015)... ... November 25, 2015 , ... Catalent Pharma Solutions, ... biologics, consumer health and global clinical supply services, today announced that Dr. Christine ... Supply East Asia Conference, to be held at the InterContinental Seoul COEX Hotel, ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... 25, 2015 WuXi PharmaTech (Cayman) Inc. ("WuXi" ... open-access R&D capability and technology platform company serving the ... China and the ... extraordinary general meeting of shareholders held today, the Company,s ... and approve the previously announced agreement and plan of ...
(Date:11/24/2015)... N.C. , Nov. 24, 2015  In the ... projects in an effort to quickly uncover new insights, ... --> --> However, ... a market research project and ensure that all rules ... and industry standards. Another major barrier to efficiently launching ...
(Date:11/24/2015)... Va. , Nov. 24, 2015  DILON Diagnostics ... have signed an agreement for DILON to distribute GE,s ... across the globe. The signing of this distribution agreement will ... NM750b Molecular Breast Imaging system and is considered an ... provide better healthcare solutions for clinicians and their patients. ...
Breaking Medicine Technology: