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New Cancer Drug Boosts Blood Pressure
Date:1/3/2008

mber for the The Lancet study, sunitinib's maker, Pfizer Inc., agreed that these heart risks do exist. However, the company added that the cardiovascular events "were medically manageable in most patients and underscore the importance of having a collaborative team of health-care professionals working together to appropriately manage patients who have limited available options" in treating their cancer.

In the statement, Pfizer added that, "Lower incidences of cardiovascular effects have been observed in subsequent randomized Phase 3 prospective Sutent [sunitinib] studies in both renal cell carcinoma and gastrointestinal stromal tumor[s]." That includes a lower incidence of events such as congestive heart failure, impaired heart function, and high blood pressure that were noted in Chen's retrospective analysis, the company said.

More information

For more on sunitinib, visit the U.S. National Library of Medicine.



SOURCES: Michel Azizi, M.D., Ph.D., professor, vascular medicine, Georges Pompidou European Hospital, Paris; Ming Hui Chen, M.D., assistant professor, medicine, Harvard Medical School, Cardiology Department, Children's Hospital Boston; Jan. 3, 2008, New England Journal of Medicine


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