Navigation Links
New Cancer Classification System Might Boost Patient Outcomes
Date:8/7/2014

THURSDAY, Aug. 7, 2014 (HealthDay News) -- Changes to the way cancers are classified could lead to more accurate diagnoses and perhaps more effective treatments in about one in 10 cancer patients, new research suggests.

Typically, cancers are categorized according to the tissue in which they originated, such as breast, bladder or kidney cancer. But tissues are composed of different types of cells.

In this study, researchers who analyzed more than 3,500 tumor samples of 12 different cancer types concluded that defining tumors by their cellular and molecular features, rather than by the tissues in which they originated, would improve diagnoses in about 10 percent of cancer cases.

"This genomic study not only challenges our existing system of classifying cancers based on tissue type, but also provides a massive new data resource for further exploration, as well as a comprehensive list of the molecular features distinguishing each of the newly described cancer classes," study co-senior author Dr. Christopher Benz, professor at the Buck Institute for Research on Aging at the University of California, San Francisco, said in a university news release.

The study, published online Aug. 7 in the journal Cell, is part of The Cancer Genome Atlas initiative, which is led by the U.S. National Cancer Institute and U.S. National Human Genome Research Institute.

The researchers report particularly significant findings in bladder and breast cancers. They identified at least three different subtypes of bladder cancer, including one that was nearly identical to a form of non-small cell lung cancer called lung adenocarcinoma, and another most similar to squamous-cell cancers of the head and neck and of the lungs.

The findings may explain why bladder cancer patients "often respond very differently when treated with the same systemic therapy for their seemingly identical cancer type," Benz said.

The researchers confirmed known differences between two forms of breast cancers called basal-like and luminal. But they also discovered that these differences are significant and that basal-like breast cancers -- commonly referred to as triple-negative -- are a distinct class of tumor.

"What's amazing is that basal breast cancer is as different from luminal breast cancer as it is from, say, kidney cancer," study co-lead author Denise Wolf, a research scientist based in UCSF's Department of Laboratory Medicine, said in the news release.

Basal-like cancers are highly aggressive and more common among black and younger women.

"Even though these basal-like cancers arise in the breast, on the molecular level they have more in common with ovarian cancers and cancers of squamous-cell origin than with other subtypes of breast cancer," explained study co-lead author Christina Yau, a staff scientist at the Buck Institute and assistant professor of surgery at UCSF.

"This is the first time ever you've been able to point to important molecular features shared by basal breast cancer, and by squamous head-and-neck cancer and lung cancer," Wolf said.

"And the same is true of immune activation -- we found that different cancer types have very similar immune signatures, a factor that may be relevant clinically with the rise of new immune therapies," she added.

Further research could reveal that as many as 30 to 50 percent of cancers need to be reclassified, according to Benz.

"Although follow-up studies are needed to validate and refine this newly proposed cancer classification system, it will ultimately provide the biologic foundation for that era of personalized cancer treatment that patients and clinicians eagerly await," Benz believes.

More information

The U.S. National Library of Medicine has more about cancer.

SOURCE: University of California, San Fransciso, news release, Aug. 7, 2014

--


'/>"/>
Copyright©2014 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cell mechanics may hold key to how cancer spreads and recurs
2. Sharp Rise in Risk With New Breast Cancer Gene, Scientists Say
3. NuvOx Pharma Begins Clinical Trial to Treat Brain Cancer
4. Gut microbiome analysis improved noninvasive colorectal cancer screening
5. Young Cancer Patients at Loma Linda University Children's Hospital Treated to an Afternoon of Fun with UCLA Football Players, Sponsored by Stater Bros
6. Gene increases risk of breast cancer to 1 in 3 by age 70
7. Daily Aspirin May Help Prevent Cancer, Study Shows
8. Cancer Diagnostics Universe Discussed in Comprehensive VPG Research Study Published at MarketPublishers.com
9. One in 10 Cancer Survivors Still Smoke Years Later, Study Finds
10. Study shows low uptake of colorectal cancer screening by African Americans in a Veterans Affairs healthcare network
11. Allegheny Health Network Team Develops Biomarker for Early Detection of Esophageal Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Cancer Classification System Might Boost Patient Outcomes
(Date:12/8/2016)... Cincinnati, OH (PRWEB) , ... December 08, 2016 ... ... offering insurance and financial planning services from offices headquartered in Hamilton County, is ... animal rescue LuvFurMutts. , LuvFurMutts specializes in finding new homes for orphaned or ...
(Date:12/8/2016)... , ... December 08, 2016 , ... ... offices that serve communities in and around the greater Phoenix metropolitan region, is ... Youth Connection. , The mission of the Homeless Youth Connection is to promote ...
(Date:12/8/2016)... ... December 08, 2016 , ... The Compretta Insurance Agency, a family owned insurance ... around the Hancock County area, is announcing the launch of a charity effort aimed ... Hancock County Food Pantry has worked for more than 30 years to meet the ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... to families and business owners in and around central Kansas, is joining the ... at-risk youth in the region. , Headquartered in Wichita, Youth Horizons works to ...
(Date:12/7/2016)... ... 07, 2016 , ... Students attending Envision’s summer 2017 ... get hands-on experience in an emergency medical simulation, When Care is Hours Away. ... real-life medical skills that are critical success in a future career and beyond. ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... A Small Business Innovative Research (SBIR) grant ... (NIH) to Phoenix -based NeuroEM Therapeutics, ... grant will seek to determine an optimal set of ... waves to treat Alzheimer,s Disease. The grant will also ... treat other neurologic disorders such as Parkinson,s Disease and ...
(Date:12/8/2016)... -- Economic growth in the United States will continue in ... in their December 2016 Semiannual Economic Forecast. Expectations are ... in mid-2009, as indicated in the monthly ISM ® ... manufacturing sector is optimistic about growth in 2017, with ... the non-manufacturing sector indicates that 14 of its industries ...
(Date:12/8/2016)... LOS ANGELES , Dec. 8, 2016 /PRNewswire/ ... and manufacturing of dissolution testing and diffusion testing ... has been acquired by Teledyne Instruments, Inc. ("Teledyne"). ... Hanson,s long-proven line of precision testing instruments, as ... while accelerating development of new products and services. ...
Breaking Medicine Technology: