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New CHARISMA Outcome Study Results Validate Aspirin Effect
Date:10/21/2008

Corgenix Medical's AspirinWorks(R) Test could change how millions worldwide

are tested for aspirin effect and treated for heart disease

DENVER, Oct. 21 /PRNewswire-FirstCall/ -- Corgenix Medical Corporation (OTC Bulletin Board: CONX) announces that new CHARISMA trial findings published in Circulation confirm that elevated urinary levels of the biomarker 11-dehydro thromboxane B2 (11dhTxB2) indicate an increased risk of heart attack, stroke and cardiac death.

The AspirinWorks(R) Test by Corgenix is the only FDA-cleared test that measures urinary 11dhTxB2 to accurately determine aspirin effect in apparently healthy individuals. 11dhTxB2 is a metabolite of thromboxane, the target of aspirin therapy.

The new findings, published in the October 21 issue of the American Heart Association's peer-reviewed medical journal Circulation, directly link increased levels of this powerful biomarker to a patient's risk of heart attack and stroke, potentially changing how millions of people worldwide are tested for aspirin effect and treated to prevent heart attacks and strokes.

The sub-study of the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) trial was carried out with the pre-FDA-cleared version of the AspirinWorks Test. The test subsequently received FDA clearance in May 2007 and is available worldwide.

Cardiologist Paul A. Gurbel, M.D., Director, Sinai Center for Thrombosis Research at Sinai Hospital of Baltimore, said the study supports that measurement of urinary 11-dehydro thromboxane B2 can identify patients at risk for ischemic events and can be used as an independent risk factor for heart disease and stroke.

"Interestingly, the investigators observed a dose-dependent effect of aspirin on levels of this marker," explained Gurbel. "These data are consistent with our previous randomized data from the double crossover ASPECT study that evaluated the effect of thre
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SOURCE Corgenix Medical Corporation
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