Navigation Links
New Blood Test Advances Individualized Cancer Therapy and Cuts Down on Need for Painful Biopsies
Date:7/24/2014

Bethesda, MD (PRWEB) July 24, 2014

The first-ever successful isolation and culture of rare tumor cells circulating in a patient’s blood has been achieved by NFCR-supported scientist Daniel Haber, M.D., Ph.D., and his team at Massachusetts General Hospital. This is an important milestone on the road to individualized cancer therapy, a new approach to selecting the best treatment for each patient.

“Tumors evolve in response to treatment,” said Dr. Haber. “They often acquire new genetic features that make them resistant to drugs. If we can monitor those changes in real time, we stand a better chance of matching the right treatments with the right patients against those new changes in their tumors.” With the success of the CTC-iChip, it is now possible to do just that.

The CTC-iChip is a business card-sized device developed by MGH bioengineer Dr. Mehmet Toner, Dr. Haber and their collaborators that can capture extraordinarily rare “circulating tumor cells” (CTCs) from a patient’s blood sample – one tumor cell per billion blood cells. Recent improvements in the chip make it easier to remove CTCs from the filter device and grow them in cell culture dishes in the labs.

As part of the experiment, the researchers took multiple blood samples from women with breast cancer over the course of their treatment, and were able to monitor the development of new mutations in their CTCs. Because this approach starts with a simple blood test, changes in the tumor cells can be assessed over time without the need for repeated, invasive, and painful biopsies.

Using the CTC-derived tumor models grown in the lab, Dr. Haber’s team could also test various combinations of drugs to see which were effective. This technique could provide a new way to help physicians develop personalized cancer treatment plans for individual patients. Dr. Haber and his team are now focused on optimizing CTC culture conditions, improving efficiency, bringing down costs, and meeting the remaining challenges to bring individualized therapy into the clinic.

“At NFCR we take the long view of cancer research, and our support of Dr. Haber’s research over the past decade is paying off,” said Franklin Salisbury, Jr., President of NFCR. “We could not be more proud of what Dr. Haber and his colleagues at MGH have accomplished, and we have every confidence that they will continue to improve this technique, making individualized therapy a reality for cancer patients everywhere.”

Dr. Haber has received NFCR support since 2003. Dr. Haber’s findings were published in the July 11 issue of the journal Science.

About the National Foundation for Cancer Research

The National Foundation for Cancer Research (NFCR) is a leading cancer research charity dedicated to funding cancer research and public education relating to cancer prevention, earlier diagnosis, better treatments and, ultimately, a cure for cancer. NFCR promotes and facilitates collaboration among scientists to accelerate the pace of discovery from bench to bedside. NFCR is committed to Research for a Cure - cures for all types of cancer. For more information, visit http://www.nfcr.org/ or call (800) 321-CURE (2873).

Read the full story at http://www.prweb.com/releases/2014/07/prweb12042342.htm.


'/>"/>
Source: PRWeb
Copyright©2014 Vocus, Inc.
All rights reserved

Related medicine news :

1. Infection Might Raise Blood Clot Risk for Older Adults: Study
2. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
3. Common Blood Pressure Drug Safe for Heart Failure: Study
4. Certain Birth Control Pills May Carry Higher Blood Clot Risk: FDA
5. High Blood Pressure May Be Especially Lethal for Blacks
6. Changes in gene expression may help explain high blood pressure in pregnancy
7. Researchers Develop Blood Test for Depression
8. Naturopathic care can improve blood sugar, mood in diabetes
9. Diabetes Groups Issue New Guidelines on Blood Sugar
10. Exercise May Help Patients With High Blood Pressure Live Longer
11. Additional blood pressure screening may reduce incidence of CVD events and death by up to 3 percent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... ... Digital Scientists, a software innovation lab specializing in web design and ... Carolina location. The lab has set up shop at the renowned NEXT Innovation ... Carolina clients for years from our office here in Atlanta,” explains Digital Scientists’ CEO, ...
(Date:3/24/2017)... Lake Orion, MI (PRWEB) , ... March 24, ... ... providing insurance assistance, financial planning, and related services to families and business owners ... charity initiative aimed at feeding regional families struggling with financial difficulties. , The ...
(Date:3/24/2017)... CA (PRWEB) , ... March 24, 2017 , ... ... on two panels at the Advanced ERISA Benefit Claims Litigation seminar in Chicago, ... Creating the Administrative Record, The majority of cases litigated under ERISA involve claims ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... first Certified Medical Reiki™ Master in Frederick, MD. Judy says, “I am passionate ... during what is often a very difficult and challenging time.” , A Certified ...
(Date:3/24/2017)... ... ... Adventures of Joey, The Dog Who Barks at Puddles”: a boisterous story about a ... God intended. “The Adventures of Joey, The Dog Who Barks at Puddles” is the ... writing, especially about truth and human behavior. , Published by Christian Faith Publishing, Patti ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Tenn. , March 23, 2017  Provectus ... or the "Company"), a clinical-stage oncology and dermatology ... announced Definitive Financing Commitment Term Sheet (the "Definitive ... a group of the Company,s stockholders, who are ... Group" in a Form 8-K filed with the ...
(Date:3/23/2017)... 23, 2017 The key factors driving ... diabetic population, accelerating economic growth and increasing healthcare expenditure. Some ... higher life expectancy of ESRD patients, rising demand for home ... the expansion of the market is hindered by high treatment ... ...
(Date:3/23/2017)... 23, 2017 As a result of ... the prevalence of allergic diseases, cutting edge developments ... revolutionising the ways in which pharmaceutical and biotech ... promises to be both a high quality meeting ... interest groups, immunologists, research scholars and doctors. The ...
Breaking Medicine Technology: