Navigation Links
New Blood Test Advances Individualized Cancer Therapy and Cuts Down on Need for Painful Biopsies
Date:7/24/2014

Bethesda, MD (PRWEB) July 24, 2014

The first-ever successful isolation and culture of rare tumor cells circulating in a patient’s blood has been achieved by NFCR-supported scientist Daniel Haber, M.D., Ph.D., and his team at Massachusetts General Hospital. This is an important milestone on the road to individualized cancer therapy, a new approach to selecting the best treatment for each patient.

“Tumors evolve in response to treatment,” said Dr. Haber. “They often acquire new genetic features that make them resistant to drugs. If we can monitor those changes in real time, we stand a better chance of matching the right treatments with the right patients against those new changes in their tumors.” With the success of the CTC-iChip, it is now possible to do just that.

The CTC-iChip is a business card-sized device developed by MGH bioengineer Dr. Mehmet Toner, Dr. Haber and their collaborators that can capture extraordinarily rare “circulating tumor cells” (CTCs) from a patient’s blood sample – one tumor cell per billion blood cells. Recent improvements in the chip make it easier to remove CTCs from the filter device and grow them in cell culture dishes in the labs.

As part of the experiment, the researchers took multiple blood samples from women with breast cancer over the course of their treatment, and were able to monitor the development of new mutations in their CTCs. Because this approach starts with a simple blood test, changes in the tumor cells can be assessed over time without the need for repeated, invasive, and painful biopsies.

Using the CTC-derived tumor models grown in the lab, Dr. Haber’s team could also test various combinations of drugs to see which were effective. This technique could provide a new way to help physicians develop personalized cancer treatment plans for individual patients. Dr. Haber and his team are now focused on optimizing CTC culture conditions, improving efficiency, bringing down costs, and meeting the remaining challenges to bring individualized therapy into the clinic.

“At NFCR we take the long view of cancer research, and our support of Dr. Haber’s research over the past decade is paying off,” said Franklin Salisbury, Jr., President of NFCR. “We could not be more proud of what Dr. Haber and his colleagues at MGH have accomplished, and we have every confidence that they will continue to improve this technique, making individualized therapy a reality for cancer patients everywhere.”

Dr. Haber has received NFCR support since 2003. Dr. Haber’s findings were published in the July 11 issue of the journal Science.

About the National Foundation for Cancer Research

The National Foundation for Cancer Research (NFCR) is a leading cancer research charity dedicated to funding cancer research and public education relating to cancer prevention, earlier diagnosis, better treatments and, ultimately, a cure for cancer. NFCR promotes and facilitates collaboration among scientists to accelerate the pace of discovery from bench to bedside. NFCR is committed to Research for a Cure - cures for all types of cancer. For more information, visit http://www.nfcr.org/ or call (800) 321-CURE (2873).

Read the full story at http://www.prweb.com/releases/2014/07/prweb12042342.htm.


'/>"/>
Source: PRWeb
Copyright©2014 Vocus, Inc.
All rights reserved

Related medicine news :

1. Infection Might Raise Blood Clot Risk for Older Adults: Study
2. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
3. Common Blood Pressure Drug Safe for Heart Failure: Study
4. Certain Birth Control Pills May Carry Higher Blood Clot Risk: FDA
5. High Blood Pressure May Be Especially Lethal for Blacks
6. Changes in gene expression may help explain high blood pressure in pregnancy
7. Researchers Develop Blood Test for Depression
8. Naturopathic care can improve blood sugar, mood in diabetes
9. Diabetes Groups Issue New Guidelines on Blood Sugar
10. Exercise May Help Patients With High Blood Pressure Live Longer
11. Additional blood pressure screening may reduce incidence of CVD events and death by up to 3 percent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... More than half of American ... percent of parents report speaking with their child about sex related topics, less than ... , Mediaplanet is proud to announce the launch of its second edition of the ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... Sourced from ... has some unique properties including its unmatched natural purity of just 6 ppm TDS ... and crisp. , Nothing Water has been available in several ShopRite and FoodTown stores ...
(Date:12/2/2016)... ... 2016 , ... On November 24th, 2016, Thanksgiving morning, Branches ... sites throughout Miami-Dade and Broward counties. This is the largest meal delivery effort ... morning by putting together individual meals via assembly lines and passing them off ...
(Date:11/30/2016)... ... November 30, 2016 , ... Northridge dentists, ... dental plan for all patients. Understanding that budget can play a part in ... number of perks, including discounts on many valuable dental treatments. Options for individuals, ...
(Date:11/30/2016)... ... November 30, 2016 , ... In recent policy debates, ... of public policymakers and system stakeholders in many states. To help them understand ... Price Index for Workers’ Compensation, Eighth Edition (MPI-WC) . , “If you are ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... YORK , December 2, 2016 ... 5,251.11, down 1.36%; the Dow Jones Industrial Average edged 0.36% ... at 2,191.08, down 0.35%. Losses were broad based as six ... Stock-Callers.com has initiated research reports on the following Services equities: ... (NASDAQ: QGEN ), INC Research Holdings Inc. (NASDAQ: ...
(Date:12/2/2016)... 2016 The concept of rare diseases and the ... this sector has been taking shape in Europe ... aspects and initiatives related to orphan medicinal products have been ... of member states individually. Many member states in the EU ... of orphan medicinal products, the result of which took the ...
(Date:12/2/2016)... -- Around the corners of world, cancer has infused ... present over earth. Cancer has become one of those ... time this is because of the increasing incidence rates ... steady increase in global cancer incidence with its associated ... of treatment, there is increasing interest in this stringent ...
Breaking Medicine Technology: