Navigation Links
New Batch of Lupus Genes Discovered
Date:1/21/2008

International team of researchers finds fresh suspects for autoimmune disease

MONDAY, Jan. 21 (HealthDay News) -- Researchers from around the world have pinpointed a batch of genes that can trigger lupus, a complex autoimmune disorder that has defied both a clear-cut diagnosis and a cure for decades.

"It's an important moment in autoimmune disease research," noted Dr. Noel Rose, who is director of the Johns Hopkins Center for Autoimmune Disease Research. At least 1.5 million people in the United States suffer from lupus, a disease in which the body mistakenly begins to attack itself.

The papers, three of which appear in the Jan. 20 online issue of Nature Medicine and one of which is published in the Jan. 20 online issue of the New England Journal of Medicine, identify both novel and familiar genetic suspects for lupus. The findings lend support to the theory that a "consortium" of genes are responsible for the development of lupus, said Rose, who three decades ago became one of the first researchers to connect a specific gene with an autoimmune disease.

The researchers identified several new genetic players -- ITGAM, KIAA1542, PXK and rs10798269 among them -- that raise the risk of developing lupus, and they also confirmed other genetic regions already associated with the disease. Some of the genes that had been identified previously, such as PTPN22 and STAT 4, are associated with other autoimmune diseases such a rheumatoid arthritis and type 1 diabetes, the researchers noted.

"It is exactly the thing I was dreaming about so many years ago -- that there would be common genes that would be involved in many autoimmune diseases," Rose said. It's a case of the "bad luck hypothesis," which means "you inherited all of these genes that are perfectly normal regulatory genes, and you got just too many of them, and that will bias your response this way or that way" in terms of developing the disease,
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. NEJM editorial on significance and limitations of new lupus gene expression research
2. Scientists identify genes linked to lupus in women
3. Lupus in women: New genetic risk factors identified
4. Scripps research scientists find new genetic mutation that halts the development of lupus
5. Lupus Foundation of America Urges Social Security Administration Not to Adopt Proposed 5-Day Rule
6. 2007: A Watershed Year for Lupus Research and Education
7. Lupus Foundation of America Offers Webchat for Parents of Teens with Lupus on December 12 at 3:00 p.m. Eastern Time
8. S.L.E. Lupus Foundation Gala Raises Record $3.2 Million for Lupus
9. Researchers investigate ways to detect lupus-associated kidney disease
10. Research suggests targeted treatment strategies for lupus
11. Mayo Clinic shows therapy effective for reducing lupus flares
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Batch of Lupus Genes Discovered
(Date:5/23/2015)... York, NY (PRWEB) May 23, 2015 ... announced that, “the company has been the target ... as a part of the company’s ongoing Information Technology ... on health insurers.” , The most notable attack ... year when Anthem Inc., the nation’s second largest health ...
(Date:5/23/2015)... Chicago, IL (PRWEB) May 23, 2015 A ... of medical equipment from hospitals, surgery centers and other medical ... will be sold including endoscopy, lab, radiology, surgery, anesthesia, exam ... place Wednesday, May 27 and Thursday, May 28 starting at ... warehouse located at 1400 N. 25th Avenue, Melrose Park, IL ...
(Date:5/23/2015)... MD (PRWEB) May 23, 2015 Injury lawyer ... that has been passed by the Maryland legislature but which ... “The Maryland General Assembly passed HB 449 with ... Governor has not signed it into law. This bill ensures ... Evidence is growing that demonstrates the danger of fracking to ...
(Date:5/22/2015)... 2015 The American College of Traditional ... June. They will hold a webinar on the updates ... class on Classical Chinese Medicine. , Webinar – First ... Given, the Dean of Clinical Education, will lead this ... Professional Doctorate program. ACTCM is currently developing this degree ...
(Date:5/22/2015)... 2015 Hundreds of federal Xarelto ... individuals who allegedly experienced serious internal bleeding and ... move forward in the U.S. District Court, Eastern ... dated May 4, 2015, the Court has established ... stored information. Among other things, the Order sets ...
Breaking Medicine News(10 mins):Health News:One Headline Making Cyber Attack Sparks Discovery of Another 2Health News:One Headline Making Cyber Attack Sparks Discovery of Another 3Health News:One Headline Making Cyber Attack Sparks Discovery of Another 4Health News:Over 5,200 Lots of Medical Equipment Will Be Sold by Live Auction 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 3Health News:ACTCM Announces Upcoming June Events 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 3Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 4
... By Kathleen Doheny HealthDay Reporter , THURSDAY, ... bisphosphonates appear to reduce the risk of invasive breast ... "If a woman is considering bisphosphonate use for ... Rowan T. Chlebowski, a clinical oncologist at the Los ...
... , THURSDAY, June 24 (HealthDay News) -- Ninety percent of ... government report reveals. In fact, salt is so pervasive ... consume less. Too much salt can increase your blood pressure, ... "Nine in 10 American adults consume more salt than ...
... a novel radioactive compound readily and safely distinguished the ... brain scans and opens the doors to making such ... radioactive compounds. The results, reported by a Johns Hopkins ... could lead to better ways to distinguish Alzheimer,s ...
... in The Netherlands found that cyclosporine treatment is a ... cancer in liver transplant patients. Full details appear in ... journal published by Wiley-Blackwell on behalf of the American ... The 1-year survival rate after liver transplantation has dramatically ...
... have shown that antiviral treatment reduces the incidence of ... (CHB). But now, researchers from the Division of Gastroenterology ... the antiviral therapy also prevents recurrence of HCC and ... for patients with HCC is local ablation of the ...
... (June 24, 2010) A team of researchers led ... method to predict post-stroke recovery of language by measuring ... recovery has important implications for stroke survivors and their ... needs. Findings are reported online in the journal ...
Cached Medicine News:Health News:Bone-Building Pills Appear to Lower Invasive Breast Cancer Risk 2Health News:Bone-Building Pills Appear to Lower Invasive Breast Cancer Risk 3Health News:Most Americans Get Too Much Salt 2Health News:Most Americans Get Too Much Salt 3Health News:Novel radiotracer shines new light on the brains of Alzheimer's disease patients 2Health News:Higher cancer rates found in liver transplant patients receiving cyclosporine for immunosuppression 2Health News:Higher cancer rates found in liver transplant patients receiving cyclosporine for immunosuppression 3Health News:Silencing hepatitis B virus prevent recurrence of liver cancer 2Health News:New metric predicts language recovery following stroke 2
(Date:5/22/2015)... KING OF PRUSSIA, Pa. , May 22, 2015 ... CSL Behring its 2015 Corporate Leadership Award as ... science and improving the care of the bleeding disorders community.  ... and Managing Director, CSL Limited, during the NHF Annual Spring ... May 21. "The National Hemophilia Foundation is dedicated ...
(Date:5/22/2015)... 22, 2015  The Mesothelioma Victims Center is ... mesothelioma get the best possible compensation, and they are ... this rare cancer caused by exposure to asbestos ... related to treatment options such as a recent ... Mesothelioma Victims Center anytime at 866-714-6466. http://MesotheliomaVictimsCenter.Com ...
(Date:5/22/2015)... , May 20, 2015 Research and ... the "Guide to Prepare Application Dossiers for ... (2014 Edition) " report to their offering. ... one of segment market of the most growth ... medical device manufacturers and producers to penetrate such ...
Breaking Medicine Technology:National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 2National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 4Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 2Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 4Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 5China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 2China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 3
... is an affordable system offering physician ... and consistency of state-of-the-art instrument-based testing ... to obtain dependable urine chemistry results. ... of motion and superior efficiency from ...
... sensor catheters incorporate a lumen ... wire, or high-speed injection/guide wire. ... injection has two laterally opposed ... open-end pigtail extension for use ...
... Mikro-Tip Pressure Catheters; Millar manufactures and ... sensor catheters for simultaneous high fidelity ... for measuring pressure gradients across a ... vascular stenosis. The catheters are made ...
... Millar Mikro-Tip pressure intravascular catheters ... accurate method of measuring pressures in ... reusable, thromboresistant Mikro-Tip catheters are ideal ... catheters range in size from 2 ...
Medicine Products: