Navigation Links
New Avian Flu Vaccine Strategy Proposed
Date:10/8/2008

Advance shots protect those most exposed in possible pandemic, researchers suggest

WEDNESDAY, Oct. 8 (HealthDay News) -- People can be protected against a potential avian flu epidemic by getting advance shots of a vaccine that may or may not be effective against the strain causing the epidemic, British researchers suggest.

That apparently daffy strategy is scientifically sound, according to a letter in the Oct. 9 issue of the New England Journal of Medicine, because priming people with an old vaccine would make any new vaccine work faster and better.

A study of 24 people who got a now outdated avian flu vaccine seven years ago shows the strategy would work, said Dr. Iain Stephenson, a senior lecturer in infectious disease at the University of Leicester.

Those people quickly developed flu-fighting antibodies when challenged with the H5 avian flu strain that is regarded as the one most likely to spread from birds to humans and cause an epidemic, Stephenson said.

In June, U.S. researchers reported that they had developed a bird flu vaccine that appeared to be safe and more effective than the one currently approved for human use.

Three-quarters of volunteers produced antibodies against the virus after receiving a second dose of the vaccine, CELVAPAN, made by Baxter, compared with only 45 percent in the currently approved vaccine. Baxter conducted the study.

"If there were to be a pandemic of avian influenza, a vaccine would be the principal means of protecting the public," Stephenson said. "Because most people would be naive to the strain, it would very likely take two doses to produce an immune response. It is very challenging to give two doses."

And while governments have stockpiled vaccines against the H5 strain, "there are two problems," Stephenson said. "Is that vaccine a good match to the pandemic strain? H5 changes, and the emerging strain could be distant to the stockpiled vaccine.

"And considering the speed with which the pandemic might spread, even if you've got a stockpiled vaccine, it would be a challenge to use that vaccine in a two-dose strategy. But if you've got people who have been primed in advance, as we took people who were primed seven years ago, it's possible to give a single low-dose vaccine and show they get a rapid response that is reactive to all known strains."

"It's a very intriguing idea," said Ted Ross, an assistant professor of microbiology at the University of Pittsburgh Center for Vaccine Research.

Ross agreed that the current strategy of giving two flu vaccine shots two weeks apart might not meet the urgent needs of a pandemic. "I believe it is going to take too long in a bird flu pandemic," he said. "Priming the population might be protective against a wide variety of H5 viruses that we know have infected humans already. The broader the protection, the better."

However, there would be financial barriers to a program that would prime a large part of the population along the lines of the Stephenson proposal, Ross noted. "Even with the currently tested vaccine, there currently is no market for vaccinating people widely," he said.

Not everyone need be primed, Stephenson said. "You would be preparing for an event that might never happen, so safety considerations would be paramount," he said. "It is unlikely that the entire population would be covered. It might be proposed to take key personnel, first responders to a pandemic. That is a potential approach that should be considered."

Even then, a single study of 24 people is not enough to prompt such a program, Stephenson noted. "It is important that larger studies be done to confirm the finding," he said.

More information

The status of avian flu vaccines is described by the Centers for Disease Control and Prevention.



SOURCES: Iain Stephenson, M.D., senior lecturer, infectious disease, University of Leicester, England; Ted Ross, Ph.D., assistant professor, microbiology, University of Pittsburgh Center for Vaccine Research; Oct. 9, 2008, New England Journal of Medicine


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Influenza: Insights into cell specificity of human vs. avian viruses
2. Large avian flu outbreaks more likely to involve duck meat industry, experts find
3. iJET Unveils 2007 Year-in-Review Report on Avian Influenza and Pandemic Planning
4. Penn animal study identifies new DNA weapon against avian flu
5. Booster vaccination may help with possible future avian influenza pandemic
6. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
7. HPV vaccine does not appear to be effective for treating pre-existing HPV infection
8. Vaccine Stops Alzheimers Brain Tangles
9. Human Papilloma Virus vaccines may decrease chances of oral cancer
10. U.S. Teens Fall Short on Vaccine Coverage
11. Nasal Anthrax Vaccine Proves Effective in Animal Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Avian Flu Vaccine Strategy Proposed
(Date:5/31/2016)... ... 2016 , ... Sunny Isles Beach is in the Zone B floodplain where ... utility services. The time for planning is now, before a storm is approaching. , ... place. Families should follow the recommendations of the Miami-Dade County (MDC) Office of ...
(Date:5/31/2016)... ... May 31, 2016 , ... "ProDrop 3D Abstract will spark new ... level," said Christina Austin - CEO of Pixel Film Studios. , Create an ... Abstract have the ability to generate and manipulate three-dimensional shapes with ease all within ...
(Date:5/31/2016)... ... 2016 , ... Joe DiMaggio Children’s Hospital (JDCH) ... The clinic is led by a world class team of physicians, board certified ... also a team of certified vestibular therapists. , The Concussion Clinic operates ...
(Date:5/31/2016)... ... , ... According to recent statistics, there are nearly half a million ... Each physical therapy professional and every clinic has a duty to perform at ... in a competitive industry is also essential. The solution that many physical therapy leaders ...
(Date:5/31/2016)... ... May 31, 2016 , ... RF Safe's has decades of ... accessories to avoid excessive Smartphone radiation implicated in the most recent cell phone cancer ... bioRxiv preprint server on May 26th (PDF) by the National Toxicology Program ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... und GERMANTOWN, Maryland , ... Referenzdatensatz von Horizon bestätigt nachgewiesene Genauigkeit ... s   QIAGEN N.V. (NASDAQ: ... QIA) gab heute die Ergänzung seines GeneReader ... Verifizierungsdaten bekannt, die die bewährte Genauigkeit seines ...
(Date:5/31/2016)... , Germany and ... -- QIAGEN N.V. (NASDAQ: QGEN ... extensive package consisting of a quality control set and ... System, reinforcing the proven accuracy of its next-generation sequencing ... training for laboratories. QIAGEN has incorporated the Horizon Discovery ...
(Date:5/31/2016)... Mich. , May 31, 2016 Diplomat Pharmacy, ... "Diplomat Dialogue," a video conversation slated for June 7, 2016, ... event, hosted live from noon to 1 p.m. ET, will ... who helped him along the road to wellness. ... live conversations planned between patients and health care professionals, talking ...
Breaking Medicine Technology: