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New Approach to Progesterone Supplementation in ART Revealed in Recently Published White Paper
Date:4/13/2009

ort, however, recently introduced vaginal formulations such as ENDOMETRIN have demonstrated equivalent pregnancy rates to IM. This allows us to confidently prescribe a progesterone supplement that is not only effective, but can also enhance a patient's quality of life."

One of the most recent studies published that supports equivalent pregnancy rates between vaginal progesterone and IM progesterone was presented by Angeline Beltsos, MD, medical director of Fertility Centers of Illinois in Chicago and one of the expert panelists, at the 2008 American Society for Reproductive Medicine (ASRM) meeting. The analysis evaluated serum progesterone levels and pregnancy outcomes with ENDOMETRIN vaginal inserts (n=568) compared with IM progesterone (n=751). Results from the study showed equivalent pregnancy rates with vaginal progesterone versus IM progesterone. (1)

Key Findings from the Roundtable

  • Luteal phase support should be initiated on the evening of or the day after oocyte retrieval. It is critical for the first two weeks and should continue for six to eight weeks after a positive pregnancy test is obtained.

  • Medical literature strongly supports that vaginal progesterone is as efficacious as IM progesterone, in terms of pregnancy rates.

  • Vaginal progesterone likely provides improved patient comfort than IM progesterone, without sacrificing efficacy.

  • Patients should be reassured that minimal bleeding with vaginal progesterone does not affect pregnancy outcomes. Bleeding is the result of not becoming pregnant and not necessarily the cause.

  • The measurement of serum progesterone has low clinical utility when using progesterone in lut
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SOURCE Ferring Pharmaceuticals
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