Navigation Links
New Approach Keeps Tumor Cells From Refueling
Date:11/21/2008

Finding might one day lead to a novel technique to combat cancer, study says,,,,

FRIDAY, Nov. 21 (HealthDay News) -- Belgian researchers have discovered that some cancer cells use lactic acid instead of sugar for food, and this might lead to new treatments that starve and kill these cells.

To survive and proliferate, all cells in the body need to produce energy. They do this by burning sugar [glucose], a process that requires oxygen. Compared with normal cells, tumor cells have restricted access to oxygen. Some tumor cells become starved for oxygen [hypoxic] and produce lactic acid. Until now, it was believed that both types of tumor cells used glucose as their main fuel, the study authors said.

"Using models of tumor cells, we found that well-oxygenated cells use lactate [lactic acid] as a preferential substrate to produce energy," said lead researcher Pierre Sonveaux, an associate professor at the University of Louvain Medical School in Brussels.

In other words, when these oxygenated cells choose between glucose and lactic acid, they choose lactic acid, Sonveaux explained. "The well-oxygenated cells thus recycle the waste product of hypoxic cells," he said.

The researchers identified the gate through which lactic acid enters oxygenated cells -- a transporter protein called MCT1 (monocarboxylate transporter 1). "The same transporter is present in the muscle where it helps to clear lactate to prevent cramps," Sonveaux said.

Tumors are famous for co-opting normal body functions, Sonveaux said. "What we identified is thus another example of usurpation by tumor cells of a normal system diverted to promote tumor growth," he said.

In experiments with mice with tumors, Sonveaux's group used a drug to block MCT1, preventing the oxygenated cells from using lactic acid as an energy source. These cells survived by switching to glucose, and they also stopped using oxygen.

This resulted
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. New approach to screen individuals for early Alzheimers disease
2. Employers Want National Approach to Health Care—Still Believe Employer-Based System Works Best: New Survey Looks At Attitudes toward Health Care Reform and Major Health Care Issues.
3. A Bold Approach to Healthcare Reform: Eliminate Insurance Companies
4. Stress Spikes as Economy Tanks - Psychologist Identifies Why Traditional Stress Management Techniques Dont Work, and Offers Radical New Approach
5. $3.5 Million in Reimbursements for Purchases of Automated External Defibrillators (AEDs) for Texas Schools Still Unclaimed With Deadline Approaching
6. Governor Mike Huckabee Discusses How President Elect Barack Obamas Approach to Health Care Will Affect the Nation
7. Employers “Vote” on Presidential Candidates' Health Care Platforms: Prefer Middle Ground Between the Two Approaches
8. Integrative Medicine Pioneer To Host Free Groundbreaking Web Series on a Natural Approach for Treating Depression
9. New topical approach to treating nail fungus circumvents problems with current therapy
10. Genetic Approach Boosts Yeast Infection Treatment
11. Biosimilar Monoclonal Antibodies in Oncology Will Approach Blockbuster Status by 2017
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/2/2014)... HealthDay Reporter WEDNESDAY, Oct. 1, ... roses -- literally -- may face an increased risk of dying ... study of over 3,000 older Americans, researchers found those who were ... more than three times as likely to die in the next ... In fact, anosmia -- the inability to distinguish odors -- was ...
(Date:10/1/2014)... University of Adelaide have developed a model that could ... outcome from treatment - from their very first psychotic ... of factors, including clinical symptoms, cognitive abilities, MRI scans ... blood. , Speaking in the lead up to World ... Psychiatry , Professor Bernhard Baune , says ...
(Date:10/1/2014)... the brain of a rat and a robot could ... QUT leading robotics researcher. , Dr Michael Milford ... study uses new computer algorithms to enable robots to ... "This is a very Frankenstein type of project," Dr ... thing together because we,re taking the eyes of a ...
(Date:10/1/2014)... people to keep their "eyes on the prize" may ... walking, staying focused on a specific target ahead can ... people walk there faster, psychology researchers have found. Their ... around the environment naturally, offers a new strategy to ... interested in exercise if physical activity seems daunting, which ...
(Date:10/1/2014)... October 01, 2014 Bedros Keuilian is ... Boot Camp fitness boot camps, he’s also considered the ... , with sold out business summits, a line of ... consultant to a recent Spike TV reality show to ... now is the time for personal trainers and fitness ...
Breaking Medicine News(10 mins):Health News:Could a Fading Sense of Smell Point to Earlier Death? 2Health News:Could a Fading Sense of Smell Point to Earlier Death? 3Health News:Predicting the future course of psychotic illness 2Health News:Robot researcher combines nature to nurture 'superhuman' navigation 2Health News:Keeping your eyes on the prize can help with exercise, NYU study finds 2Health News:Keeping your eyes on the prize can help with exercise, NYU study finds 3Health News:Bedros Keuilian Shares Tips on Selling Personal Training for the Holidays 2Health News:Bedros Keuilian Shares Tips on Selling Personal Training for the Holidays 3
... the #1 co-ed,fitness club chain in the world, has ... has clubs operating in 46 states, Canada and Australia,serving ... other well-known fitness chains have recently scaled back their,expansion ... grow at,an impressive rate. In fact, in the past ...
... the eye region is also useful when trying to spot fatigue ... or less tired? Focus on the area around your eyes, a ... your age and level of fatigue. , When asked to ... looked at the eye region almost half the time, researchers ...
... profound impact on this country,s psyche. Eight years after ... events affected us. A number of studies have shown ... the terrorist attacks experienced heightened levels of stress and ... Research has also indicated that elevated levels of stress ...
... PARK, N.J. and NEW YORK, Feb. 2 HLTH Corporation ... subsidiary, WebMD Health Corp. (Nasdaq: WBMD ), today ... the three months ended December 31, 2008 at approximately 4:00 ... will host a conference call at 4:45 pm (ET) on ...
... SCOLR Pharma, Inc. (NYSE Alternext US: DDD) today announced ... Ph.D., M.B.A., to serve as president and chief executive officer. ... SCOLR Pharma board of directors since August 2007.Michael N. Taglich, ... very pleased that Dr. Morra has agreed to become SCOLR ...
... (TFAH) strongly supports President Obama,s call for a "complete ... outbreak of Salmonella tied to peanut butter ... Salmonella outbreaks in 2008 highlight the need ... released a comprehensive report, Fixing Food Safety: Protecting ...
Cached Medicine News:Health News:Anytime Fitness Opens 1,000th Club 2Health News:Anytime Fitness Opens 1,000th Club 3Health News:When Gauging Age, the Eyes Have It 2Health News:Driving under the influence (of stress): Regional effects of 9/11 attacks on driving 2Health News:HLTH and WebMD Announce Fourth Quarter Earnings Release Date and Conference Call 2Health News:SCOLR Pharma, Inc. Announces Appointment of Bruce S. Morra, Ph.D., as President & CEO 2Health News:SCOLR Pharma, Inc. Announces Appointment of Bruce S. Morra, Ph.D., as President & CEO 3Health News:Trust for America's Health Applauds President Obama's Call for a Complete Review of the U.S. Food Safety System 2Health News:Trust for America's Health Applauds President Obama's Call for a Complete Review of the U.S. Food Safety System 3
(Date:10/2/2014)... , Oct. 1, 2014 The global high ... marked by the ,Threat of Obsolescence, wherein technologies as ... rapidly. Pharmaceutical and biotechnology companies as well as academic ... content screening as a powerful research tool in drug ... fastest-growing segment in the high content screening market. In ...
(Date:10/1/2014)... 1, 2014   Plexus Information Systems, Inc. ... Information Management Systems (AIMS), announced a partnership with ... wholly owned subsidiary of Quality Systems, Inc. and ... connectivity solutions.  Logo - ... This partnership extends the NextGen Healthcare ...
(Date:10/1/2014)... NEW YORK , October 1, 2014 ... provider for the medical industries, announced today the expansion of its ... New York City . genae Americas was incorporated in 2011. ... centered in one of the highest concentrations of medical innovation and ... , President at genae Americas. "The expansion of genae from ...
Breaking Medicine Technology:High Content Screening Market by Instruments (Cell Imaging and Analysis System), by Applications (Primary and Secondary Screening, Target Identification and Validation, Toxicity Studies, Compound Profiling), Software & Services - Global Forecasts to 2High Content Screening Market by Instruments (Cell Imaging and Analysis System), by Applications (Primary and Secondary Screening, Target Identification and Validation, Toxicity Studies, Compound Profiling), Software & Services - Global Forecasts to 3Plexus IS' Anesthesia Documentation Solution Strengthens NextGen Healthcare Product Offering 2Plexus IS' Anesthesia Documentation Solution Strengthens NextGen Healthcare Product Offering 3genae Opens Offices in New York City 2
... SILVER SPRING, Md., June 8, 2011 The Food and ... containing 80 mg of simvastatin — the highest approved dose ... of the risk of muscle injury. (Logo:   ... only be used by patients who have been taking it ...
... Merz Pharmaceuticals today announced that new data on ... from accessory (complexing) proteins, will be presented at ... of Parkinson,s Disease and Movement Disorders in Toronto, ... XEOMIN were safe and effective in the treatment ...
Cached Medicine Technology:FDA CONSUMER HEALTH INFORMATION - Limit Use of 80 mg Simvastatin 2New Data On Xeomin® (IncobotulinumtoxinA) To Be Presented At The 15th International Congress Of Parkinson's Disease And Movement Disorders (MDS) 2New Data On Xeomin® (IncobotulinumtoxinA) To Be Presented At The 15th International Congress Of Parkinson's Disease And Movement Disorders (MDS) 3
The Stat-Let lines of disposable lancets are all designed with the goals of providing a safe and easy to achieve capillary blood sampling. All of our lancets can be used by most current models of lan...
Lancets are the fine needles used with a lancing device to draw a blood sample for glucose testing. To make testing less painful, we developed lancets with extra-thin tips....
... The HEMOCHRON Jr. Signature Microcoagulation System ... bedside with just one drop (.015cc) of ... a portable, hand-held, battery-operated instrument, the HEMOCHRON ... capabilities and print (optional) both patient and ...
Inquire...
Medicine Products: