Navigation Links
New Approach Keeps Tumor Cells From Refueling
Date:11/21/2008

Finding might one day lead to a novel technique to combat cancer, study says,,,,

FRIDAY, Nov. 21 (HealthDay News) -- Belgian researchers have discovered that some cancer cells use lactic acid instead of sugar for food, and this might lead to new treatments that starve and kill these cells.

To survive and proliferate, all cells in the body need to produce energy. They do this by burning sugar [glucose], a process that requires oxygen. Compared with normal cells, tumor cells have restricted access to oxygen. Some tumor cells become starved for oxygen [hypoxic] and produce lactic acid. Until now, it was believed that both types of tumor cells used glucose as their main fuel, the study authors said.

"Using models of tumor cells, we found that well-oxygenated cells use lactate [lactic acid] as a preferential substrate to produce energy," said lead researcher Pierre Sonveaux, an associate professor at the University of Louvain Medical School in Brussels.

In other words, when these oxygenated cells choose between glucose and lactic acid, they choose lactic acid, Sonveaux explained. "The well-oxygenated cells thus recycle the waste product of hypoxic cells," he said.

The researchers identified the gate through which lactic acid enters oxygenated cells -- a transporter protein called MCT1 (monocarboxylate transporter 1). "The same transporter is present in the muscle where it helps to clear lactate to prevent cramps," Sonveaux said.

Tumors are famous for co-opting normal body functions, Sonveaux said. "What we identified is thus another example of usurpation by tumor cells of a normal system diverted to promote tumor growth," he said.

In experiments with mice with tumors, Sonveaux's group used a drug to block MCT1, preventing the oxygenated cells from using lactic acid as an energy source. These cells survived by switching to glucose, and they also stopped using oxygen.

This resulted
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. New approach to screen individuals for early Alzheimers disease
2. Employers Want National Approach to Health Care—Still Believe Employer-Based System Works Best: New Survey Looks At Attitudes toward Health Care Reform and Major Health Care Issues.
3. A Bold Approach to Healthcare Reform: Eliminate Insurance Companies
4. Stress Spikes as Economy Tanks - Psychologist Identifies Why Traditional Stress Management Techniques Dont Work, and Offers Radical New Approach
5. $3.5 Million in Reimbursements for Purchases of Automated External Defibrillators (AEDs) for Texas Schools Still Unclaimed With Deadline Approaching
6. Governor Mike Huckabee Discusses How President Elect Barack Obamas Approach to Health Care Will Affect the Nation
7. Employers “Vote” on Presidential Candidates' Health Care Platforms: Prefer Middle Ground Between the Two Approaches
8. Integrative Medicine Pioneer To Host Free Groundbreaking Web Series on a Natural Approach for Treating Depression
9. New topical approach to treating nail fungus circumvents problems with current therapy
10. Genetic Approach Boosts Yeast Infection Treatment
11. Biosimilar Monoclonal Antibodies in Oncology Will Approach Blockbuster Status by 2017
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2015)... ... July 28, 2015 , ... A new study ... inmates who continued methadone maintenance treatment (MMT) during incarceration versus those subjected to ... to opiate use (1) and more likely to require hospitalization or emergency treatment ...
(Date:7/28/2015)... Savannah, Tenn. (PRWEB) , ... July 28, 2015 ... ... span July through October this year, as volunteers celebrate the 14th year of ... Morgan and Tracy Lawrence in downtown Savannah for this year’s main concert Saturday, ...
(Date:7/28/2015)... ... ... By 2016, the number of smartphones worldwide will surpass 2 billion. This ... personal basis, increasing customer loyalty. However, capitalizing on this is not always obvious. Companies ... more nimble competitors. , The Open Mobile Summit 2015 is an influential gathering of ...
(Date:7/28/2015)... (PRWEB) , ... July 28, 2015 , ... Dr. ... the arrival of Dr. Sudeep Roy in July 2016. Coming to Austin from ... with Dr. Buckingham. The twelve-month long training is facilitated annually by the American ...
(Date:7/28/2015)... (PRWEB) , ... July 28, 2015 , ... ... announced today that the company is in full support of National Immunization Awareness ... sometimes deadly diseases. To stay protected against serious illnesses like the flu, measles, ...
Breaking Medicine News(10 mins):Health News:Novus Medical Detox Center Analyzes Methadone Study Findings and Implications for Opiate Abuse Treatment 2Health News:Novus Medical Detox Center Analyzes Methadone Study Findings and Implications for Opiate Abuse Treatment 3Health News:Novus Medical Detox Center Analyzes Methadone Study Findings and Implications for Opiate Abuse Treatment 4Health News:Worley’s 14th Tennessee River Run Will Host Wade Hayes, Lorrie Morgan, Tracy Lawrence and Others 2Health News:Worley’s 14th Tennessee River Run Will Host Wade Hayes, Lorrie Morgan, Tracy Lawrence and Others 3Health News:Open Mobile Media: Etsy, Google, The Weather Company, CBS, TaskRabbit and New York Times: Moving from Web to Mobile-First 2Health News:Open Mobile Media: Etsy, Google, The Weather Company, CBS, TaskRabbit and New York Times: Moving from Web to Mobile-First 3Health News:Buckingham Center for Facial Plastic Surgery Welcomes Fellow 2Health News:Buckingham Center for Facial Plastic Surgery Welcomes Fellow 3Health News:CareMed Urgent & Primary Care Supports National Immunization Awareness Month 2Health News:CareMed Urgent & Primary Care Supports National Immunization Awareness Month 3
... ... Farmed, Locally Grown, Organic Produce Plus Monthly Special Offers , ... (PRWEB) May 24, 2010 -- The Webb ... free program that provides shoppers with savings on organic and sustainably-farmed produce, plus access ...
... ... Helps Them Feel Better , ... (PRWEB) May 24, 2010 -- He,s no guru. And he’s not selling a philosophy, a ... for seven years. Still the stories surrounding this young Croatian have spawned hundreds of thousands ...
... women are less likely than Caucasians and men to ... blood. That is the conclusion of a new analysis ... journal of the American Cancer Society. The study,s results ... disparities exist in access to bone marrow transplantation and ...
... More research is needed to explore reasons why, study ... Men in a relationship with an HIV-positive woman face ... partner is pregnant, new research reveals. , The finding ... Conference in Pittsburgh. , The two-year study -- launched ...
... , ... Essence of Innovation and Survival , ... Placentia, CA (Vocus) May 23, 2010 -- Xlibris, the world’s leading print-on-demand self-publishing services ... the deck of creativity and innovation, a new book authored by Ralph M. Frid, Ph.D., ...
... ... Living a Healthy Long Life , ... Mariposa, CA (Vocus) May 23, 2010 -- Health enthusiasts and interested individuals are in ... Any Age. Packed with relevant knowledge and informative discussions, this book will help readers achieve ...
Cached Medicine News:Health News:Webb Ranch Farmers Market Introduces the Harvest Advantage Card 2Health News:Webb Ranch Farmers Market Introduces the Harvest Advantage Card 3Health News:Webb Ranch Farmers Market Introduces the Harvest Advantage Card 4Health News:Regular Guy "Braco" Healing Masses in Europe 2Health News:African-Americans and women are less likely to undergo bone marrow transplantation 2Health News:Female-to-Male HIV Transmission Risk Doubles During Pregnancy 2Health News:Xlibris Releases Trumping the Red Queen 2Health News:Xlibris Releases Trumping the Red Queen 3Health News:The Secret on How to Live Healthy at Any Age 2
(Date:7/28/2015)... 2015 Amgen (NASDAQ: AMGN ) announced ... per share dividend for the third quarter of 2015. ... to all stockholders of record as of the close ... About Amgen Amgen is committed to unlocking the potential ... discovering, developing, manufacturing and delivering innovative human therapeutics. This ...
(Date:7/28/2015)...   Regulus Therapeutics Inc . ( NASDAQ: RGLS ... of innovative medicines targeting microRNAs, today announced that it ... ended June 30, 2015 on Tuesday, August 4, 2015, ... Regulus will host a conference call and webcast on ... Time to discuss its second quarter 2015 financial results ...
(Date:7/28/2015)... Calif. , July 28, 2015 On ... Corp., the parent company of CPI International, Inc. (CPI), ... quarter ended July 3, 2015 with the Securities and ... its results for the quarter.  At 11 a.m. (EDT) ... telephonic conference call in conjunction with this release that ...
Breaking Medicine Technology:Amgen Announces 2015 Third Quarter Dividend 2Amgen Announces 2015 Third Quarter Dividend 3Regulus Announces Timing for Second Quarter 2015 Financial Results Webcast and Conference Call 2Regulus Announces Timing for Second Quarter 2015 Financial Results Webcast and Conference Call 3CPI International To Announce Third Quarter 2015 Financial Results 2
... Cell Therapeutics, Inc. (CTI),(Nasdaq and MTA: CTIC) today announced that the following presentations,will ... formerly XYOTAX(TM)),at the 44th American Society of Clinical Oncology (ASCO) Annual Meeting,May 30 through ... Poster # ... (Abstract#) Sat., ...
... First and Only Treatment for Hunter Syndrome Now Approved in ... ... Worldwide, BASINGSTOKE, England and CAMBRIDGE, Massachusetts, May ... company, announced that ELAPRASE(R),(idursulfase), a human enzyme replacement therapy for ...
Cached Medicine Technology:Cell Therapeutics, Inc. (CTI) Announces Presentations at American Society of Clinical Oncology (ASCO) Annual Meeting 2Cell Therapeutics, Inc. (CTI) Announces Presentations at American Society of Clinical Oncology (ASCO) Annual Meeting 3Shire Announces Approval of ELAPRASE(R) (idursulfase) in Brazil 2Shire Announces Approval of ELAPRASE(R) (idursulfase) in Brazil 3Shire Announces Approval of ELAPRASE(R) (idursulfase) in Brazil 4Shire Announces Approval of ELAPRASE(R) (idursulfase) in Brazil 5
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: