Navigation Links
New Anti-HIV Weapons Found in Immune System
Date:7/8/2010

By Randy Dotinga
HealthDay Reporter

THURSDAY, July 8 (HealthDay News) -- Scientists report they've discovered possible new weapons in the war against HIV: antibody "soldiers" in the immune system that might prevent the AIDS virus from invading human cells.

According to the researchers, these newly found antibodies connect with and neutralize more than 90 percent of a group of HIV-1 strains, involving all major genetic subtypes of the virus.

That breadth of activity could potentially move research closer toward development of an HIV vaccine, although that goal still remains years away, at best, experts say.

The findings "show that the immune system can make very potent antibodies against HIV," said Dr. John Mascola, a vaccine researcher and co-author of two new studies published online July 8 in the journal Science.

"We are trying to understand why they exist in some patients and not others. That will help us in the vaccine design process," said Mascola.

Antibodies are warriors in the body's immune system that work to prevent infection. "Neutralizing" antibodies bind to germs and try to disable them, explained Ralph Pantophlet, an immunologist and assistant professor at Simon Fraser University in Burnaby, British Columbia, Canada.

With HIV, the antibodies are in a continual race to adjust to the virus, which evolves to escape detection. "The reason the antibodies generally do not work so well is because they're always playing catch up," said Pantophlet, who is familiar with the findings of the new studies.

However, some people's antibodies are known to cope especially well with HIV, although even these rare patients can't get rid of the virus entirely, Pantophlet said.

In the new studies, researchers report on three antibodies that appear to have major powers to fight off HIV. In a sense, the antibodies gum up a lock that the virus tries to pick to get into healthy cells, said Mascola, deputy director of the Vaccine Research Center at the U.S. National Institutes of Allergy and Infectious Diseases.

However, making antibodies in large enough quantities to boost the immune system remains a challenge, said Pantophlet.

While researchers haven't given up on that prospect, some think it's more feasible to use the new findings as another avenue to an AIDS vaccine. The idea would be to teach the body to produce the antibodies so the person is protected when exposed to the virus, Mascola said.

But that won't happen for some time, if at all. "Developing a vaccine always takes a fairly long period of research with some trial and error," Mascola said.

"The goal is to vaccinate individuals and have their own immune systems make an antibody like this," he said. "To do that, we have to design a new vaccine, study it first in animal models, and then try it in small scale human studies, and see if it does what we expect it to do. That takes a quite a bit of time and effort."

More information

To learn more about the immune system, see the U.S. National Library of Medicine.

SOURCES: John R. Mascola, M.D., Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.; Ralph Pantophlet, assistant professor, Faculty of Health Sciences, Simon Fraser University, Burnaby, B.C., Canada; July 9, 2010, Science


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Anti-HIV Drugs May Help Prevent Spread of Virus
2. One-third of antimalarial medicines sampled in 3 African nations found to be substandard
3. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
4. Highmark Foundation Awards $120,000 to the American Heart Association
5. Stuttering Foundation Hails New Research
6. Autism Science Foundation Offers IMFAR Grants to Autism Stakeholders
7. Alzheimers Foundation of America Applauds Social Security for Speeding Disability Benefits for Early-Onset Alzheimers Disease
8. Corbett Accel Healthcare Group Mourns Passing of Founder Frank J. Corbett
9. Reliv Foundation Donates $450,000 In Nutritional Supplements to Haitian Relief Efforts
10. Kaiser Foundation Health Plan and Hospitals Report Fourth Quarter and Fiscal Year 2009 Financial Results
11. Instaflex Announces Proceeds Agreement with Arthritis Foundation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Anti-HIV Weapons Found in Immune System
(Date:10/13/2017)... ... 2017 , ... While it’s often important to take certain medications during the ... Texas, has identified a solution. , She developed a prototype for MOTION LIGHT-UP PILL ... it eliminates the need to turn on a light when taking medication during the ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... PurhealthRX ... CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will ... and providing a CBD form that can be easily incorporated into liquid products, while ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton ... staged a mock evacuation of the facility as part of a disaster drill on ... Echo Hose EMS and Shelton City Emergency Manager, as well as the Connecticut ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading ... to advocate for action towards gender equality at their inaugural Summit in New York ... globe, and reached a social audience of over 3 million. To watch the Mobilize ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob Lowe, ... in a new episode of "Success Files," which is an award-winning educational program ... investigates each subject in-depth with passion and integrity. , Sciatica occurs when the ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
(Date:9/12/2017)... NEW YORK , Sept. 12, 2017   EcoVadis , the ... chains, has published the first annual edition of its Global CSR Risk ... 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings that analyzed nearly ... ... Performance Index ...
(Date:9/12/2017)... 12, 2017  ValGenesis Inc., the global leader ... pleased to announce the appointment of Dr. ... Board of Directors and Chairman of Advisory Board ... science companies to manage their entire validation lifecycle ... in this process. Furthermore, ValGenesis VLMS enables rigorous ...
Breaking Medicine Technology: