Navigation Links
New Anti-Clotting Drug May Cut Brain Bleeding Risk: Study
Date:2/2/2012

THURSDAY, Feb. 2 (HealthDay News) -- A new medication that helps prevent strokes in people with the abnormal heart rhythm disorder known as atrial fibrillation poses less risk of bleeding in the brain than a commonly used drug, research comparing rivaroxaban (Xarelto) and warfarin suggests.

Anti-clotting medications, also called blood-thinners or anticoagulants, include warfarin (Coumadin) and aspirin, among others. In patients with atrial fibrillation, these drugs can reduce the risk of ischemic stroke, which occurs when a vessel becomes clogged by a blood clot. But the drugs can also cause excessive bleeding because they make it harder for blood to clot.

In a new study, researchers led by Dr. Graeme Hankey, a neurologist at the Royal Perth Hospital and University of Western Australia, followed more than 14,000 people who took anti-clotting drugs for a median of two years. Of those patients, 136 had bleeding in the brain.

People who took a new anticoagulant called rivaroxaban (Xarelto) -- and suffered from the most common type of atrial fibrillation and didn't have heart valve damage -- were about one-third less likely to experience bleeding in the brain than those who took warfarin, the investigators found.

So which drug is best?

In the big picture, "all of the newer [blood-thinning] drugs are reported to have lower intracranial bleeding risks than Coumadin [warfarin] when used in the setting of atrial fibrillation to prevent stroke," said Dr. Ken Uchino, program director of the Vascular Neurology Fellowship at the Cleveland Clinic's Cerebrovascular Center, who was not involved with the study but is familiar with the findings.

"This is one advantage, but in absolute terms it is small -- on average going from 0.7 percent per year of intracranial bleeding risks to 0.5 percent per year for rivaroxaban -- though this is a 33 percent decrease for rivaroxaban," Uchino explained.

The new drugs are more convenient than warfarin, which requires the administration of blood tests to make sure patients are getting the proper doses. But "there have been concerns about unanticipated risks and how the new medications are all short-acting -- what happens if one misses doses? -- and cleared by the kidneys -- what happens if the kidneys start to fail without anyone knowing?" Uchino said.

Also, the newer anti-clotting drugs are expensive.

The study, which was funded by Johnson & Johnson and Bayer HealthCare, was slated for presentation Thursday at the American Stroke Association's International Stroke Conference, in New Orleans.

Because this study was presented at a medical meeting, the data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about stroke.

-- Randy Dotinga

SOURCES: Ken Uchino, M.D., program director, Vascular Neurology Fellowship, Cerebrovascular Center, Cleveland Clinic, Ohio; American Stroke Association, news release, Feb. 2, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Tests to Measure Safety of Anti-Clotting Drugs of Limited Value
2. Extended use of anti-clotting drug helps some bedridden patients
3. New Anti-Clotting Drug May Work Better After Hip Replacement
4. Anti-clotting agent does not improve outcomes of patients with severe pneumonia
5. Anti-Clotting Drug May Cause Severe Bleeding With No Benefit
6. Analysis does not support genetic test before use of anti-clotting drug
7. Gadgets not related to teenagers brain pain
8. Dementia Rates Escalate as Brain Capacity Diminishes with Age
9. Researchers discover new way to kill pediatric brain tumors
10. Scientists Pinpoint Area of Brain That Fears Losing Money
11. Physical Changes in Brain Linked to Altered Spirituality
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Anti-Clotting Drug May Cut Brain Bleeding Risk: Study
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
(Date:6/24/2016)... ... 2016 , ... People across the U.S. are sharpening their pencils and honing ... contest in which patients and their families pay tribute to a genetic counselor by ... Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & ... (TGIG), has initiated cultivation and processing operations at its production facility, and opened ... , Puradigm is the manufacturer of a complete system of proactive air and ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th ... Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised ... have been wounded in battle and their families. Venture Construction Group is a 2016 ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... ITASCA, Ill. , June 23, 2016  In a startling ... states are failing their residents by lacking a comprehensive, proven plan ... , a definitive ranking of how states are tackling the ... rating to only four states – Kentucky , ... and Vermont . Of the 28 failing states, ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology and specialty ... Bracket eCOA (SM) 6.0, at the 52 nd ... in Philadelphia , Pennsylvania.  A demonstration of ... its kind to fully integrate with RTSM, will be held ... a flexible platform for electronic clinical outcomes assessments that is ...
Breaking Medicine Technology: