Navigation Links
New Alzheimer's research suggests possible cause: The interaction of proteins in the brain
Date:6/19/2013

PORTLAND, Ore. For years, Alzheimer's researchers have focused on two proteins that accumulate in the brains of people with Alzheimer's and may contribute to the disease: plaques made up of the protein amyloid-beta, and tangles of another protein, called tau.

But for the first time, an Alzheimer's researcher has looked closely at not the two proteins independently, but at the interaction of the two proteins with each other in the brain tissue of post-mortem Alzheimer's patients and in mouse brains with Alzheimer's disease. The research found that the interaction between the two proteins might be the key: as these interactions increased, the progression of Alzheimer's disease worsened.

The research, by Hemachandra Reddy, Ph.D., an associate scientist at the Oregon National Primate Research Center at Oregon Health & Science University, is detailed in the June 2013 edition of the Journal of Alzheimer's Disease.

Reddy's paper suggests that when the interaction between the phosphorylated tau and the amyloid-beta particularly in its toxic form happens at brain synapses, it can damage those synapses. And that can lead to cognitive decline in Alzheimer's patients.

"This complex formation between amyloid beta and tau it is actually blocking the neural communication," Reddy said. "If we could somehow find a molecule that could inhibit the binding of these two proteins at the synapses, that very well might be the cure to Alzheimer's disease."

To conduct the research, Reddy and his team studied three different kinds of mice, who had been bred to have some of the brain characteristics of Alzheimer's disease, including having amyloid-beta and phosphorylated tau in their brains. Reddy also analyzed postmortem brain tissue from people who had Alzheimer's disease.

Using multiple antibodies that recognize amyloid-beta and phosphorylated tau, Reddy and Maria Manczak, Ph.D., a research associate in Reddy's laboratory, specifically looked for the evidence of the amyloid beta and phosphorylated tau interactions. They found amyloid-beta/tau complexes in the human Alzheimer's brain tissue and in the Alzheimer's disease mouse brains. The Reddy team also found much more of those amyloid-beta/tau complexes in brains where Alzheimer's disease had progressed the most.

Reddy found very little or no evidence of the same interaction in the "control" subjects mice that did not have the Alzheimer's traits and human brain tissue of people who did not have Alzheimer's.

"So much Alzheimer's research has been done to look at amyloid-beta and tau," Reddy said. "But ours is the first paper to strongly demonstrate that yes, there is an amyloid-beta/phosphorylated tau interaction. And that interaction might be causing the synaptic damage and cognitive decline in persons with Alzheimer's disease."

Reddy and his lab are already working on the next crucial questions. One is to define the binding site or sites and exactly where within the neuron the interaction of amyloid-beta and tau first occurs. The second is to find a way to inhibit that interaction and thus maybe prevent or slow the progression of Alzheimer's.


'/>"/>

Contact: Todd Murphy
murphyt@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Related medicine news :

1. Immunoglobulins Market to 2019 - Demand in Primary Immunodeficiency And CIDP Potentially Supplemented by Approval for Alzheimers Disease Available at ResearchMoz.us
2. Pharmacies and Drug Retailers in China Industry Research Report – Now Available from IBISWorld
3. New Drug Delivery Partnering Terms and Agreements Market Study Report Available at MarketResearchReports.Biz
4. Never Expose Skin to Daylight without Sunscreen Warns Water and Skin Researcher Sharon Kleyne
5. Colleen’s Dream Foundation Gifts $10,000 to The University of Arizona Cancer Center to Support Early Ovarian Cancer Detection Research
6. Research Shows that Medical Students May Have a Hidden Obesity Bias, Suggesting Weight Loss via Supplements Like Liproxenol Could Inadvertently Enhance Medical Treatment
7. International Essential Tremor Foundation Kicks Off Annual Essential Tremor Research Fundraiser, Tulips for Tremor
8. Injury Attorneys Block O'Toole & Murphy, LLP to Appear on Z100 Radio Show This Sunday to Discuss Their Support of St. Jude Children's Research Hospital
9. NYSCF and Columbia researchers demonstrate use of stem cells to analyze causes, treatment of diabetes
10. $8.7 million grant supports Gene-Environment Interaction research
11. Major grant funds UCSC researchers using big data to predict cancer outcomes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... TAMPA, Fla. (PRWEB) , ... January 23, 2017 ... ... for the nonprofit educational institution’s inaugural K-20 Education Summit to be held March ... proposals to present by Jan. 25, 2017. , The keynote speakers include Dr. ...
(Date:1/23/2017)... ... 23, 2017 , ... The iaedp Foundation, recognized for its ... who treat the full spectrum of eating disorder problems, proudly announces the addition ... of the leading eating disorder treatments centers located throughout the U.S. As partners ...
(Date:1/23/2017)... Dc (PRWEB) , ... January 23, 2017 , ... ... American University is taught by healthcare management and evaluation leaders with decades of ... fee-for-service to pay-for-value in the United States healthcare system, there is a renewed ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... in North America for the scientific development, healthcare training and clinical application of ... and its 2017 AAT Member Certification Qualification Courses for Technicians, respectively. , For ...
(Date:1/23/2017)... ... January 23, 2017 , ... METTLER TOLEDO ... Process Chemistry by Applying Simple PAT Tools . , Crystallization is ... purify the desired product. Chemists now spend more time developing better intermediate ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... -- 7D Surgical announced today that it has ... and Drug Administration (FDA) and a medical device ... commercial launch of its innovative Machine-vision Image Guided ... Surgical System.  The 7D Surgical ... vision algorithms to eliminate the long-standing barriers to ...
(Date:1/23/2017)... WASHINGTON , Jan. 23, 2017 The ... of the Pharmacy and Medically Underserved Areas ... House of Representatives. The legislation, which was previously introduced ... improve patient access to health care through pharmacists and ... bill include Representatives Brett Guthrie (R-KY), ...
(Date:1/23/2017)... 23, 2017 Stock-Callers.com today presents the ... CPRX ), Sophiris Bio Inc. (NASDAQ: ... and Agile Therapeutics Inc. (NASDAQ: AGRX ). These ... lower in late trade on Friday, January 20 th , ... while shares of health care companies in the S&P 500 ...
Breaking Medicine Technology: