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New Alzheimer's predictors advance earlier detection
Date:7/29/2008

NEW YORK, July 26, 2008 The following news tips are based on poster and oral presentations at the Alzheimer's Association 2008 International Conference to be held in Chicago from July 26 to July 31. Each presentation is embargoed for a specific date and time.

Brain Atrophy and Biomarkers May Help Identify People at Risk for Alzheimer's
Susan de Santi, Ph.D., Associate Professor, Department of Psychiatry, NYU Langone Medical Center
EMBARGOED FOR RELEASE UNTIL TUESDAY, July 29, 2008 at 12:30 p.m. CT

By combining MRI brain scans and measurements of certain compounds in the cerebrospinal fluid, NYU researchers were able to distinguish individuals who would develop Alzheimer's disease over a two-year period. In a study of 23 people, they found atrophy in areas of the brain involved in learning and memory, and significantly higher CSF levels of phosphorylated tau and other compounds among individuals who would develop Alzheimer's compared to those individuals who didn't progress from mild cognitive impairment over the two-year period. This preliminary study suggests that combining these tests could help predict which individuals with mild cognitive impairment are at the highest risk for developing Alzheimer's disease.
Presentation # P3-067

Big Immune Response to Common Mouth Bacteria Linked to Alzheimer's.
Angela R Kamer, D.M.D., M.S., PhD., Assistant Professor, College of Dentistry, New York University
EMBARGOED FOR RELEASE UNTIL SUNDAY, July 27, 2008, at 12:30 p.m. CT

In a study investigating the link between Alzheimer's disease and a heightened inflammatory-immune response, NYU researchers found that twice as many subjects with probable Alzheimer's disease tested positive for antibodies in their plasma against a type of bacteria that is commonly found in the mouth. The pioneering study supports a growing body of evidence that associates notable immune changes with a means of predicti
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Contact: Bob Brody
bob.brody@nyumc.org
212-404-3555
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

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