Navigation Links
New Alzheimer's findings: High stress and genetic risk factor lead to increased memory decline

Philadelphia, PA, August 27, 2007 High stress levels may contribute to memory loss among people at risk for developing Alzheimers disease. The 4 variant of the apolipoprotein E (APOE) gene contributes to the risk for memory loss related to Alzheimers disease. Similarly, high circulating levels of cortisol, associated with high stress levels, also impairs memory. However, the interactive effects of this risk genotype and chronic stress are not well understood, so a new study being published in the September 1st issue of Biological Psychiatry was designed to explore this relationship.

In their study, Peavy and colleagues performed genotyping and measured the chronic stress level in 91 older, healthy subjects (mean age was 78.8 years). Those low on stress or without the APOE- 4 risk factor performed better on memory measures than those with high stress or those positive for APOE-4, respectively. Those individuals experiencing high stress and who were positive for APOE- 4 showed the greatest memory impairment.

One of the authors, Guerry M Peavy, Ph.D., comments, "Perhaps the most interesting result of the study was the interaction we found between genetic status and the experience of high stress events. That is, for some aspects of memory, highly stressful experiences had a detrimental effect only on those individuals who carried the APOE-4 allele.

John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, adds:

This is a very exciting time in Alzheimers disease (AD) researchThe findings of Peavy et al. suggest that environmental factors, like chronic stress, may interact with an AD risk genotype, APOE-4, to promote age-related memory impairment. These data raise the possibility that psycho-social interventions and psychotherapeutic medications might enhance the effectiveness of medication treatment strategies aimed at preserving memory function in older adults.

As noted in their article, because APOE- 4 status and high stress levels can be assessed at any time, these findings may represent an advantage with the earlier identification of elderly individuals who do not yet meet criteria for dementia, but who clearly are more cognitively vulnerable. Dr. Peavy explains, The results of the study have implications for interventions that could prevent harmful responses to stressful experiences and, as a result, could prevent or slow the progression of cognitive changes in genetically vulnerable, older individuals. For now, longitudinal studies need to be undertaken to determine if these interactive effects of stress and APOE-4 status become predictors of a clinical diagnosis of dementia.


Contact: Jayne M. Dawkins

Related medicine news :

1. Testing genes for disease does not cause harm to children of people with Alzheimers
2. Age-Dependent Alterations Not Specific For Alzheimers Disease
3. Killing two birds (cholesterol and Alzheimers disease) with the same stone
4. Cancer Causing Protein May Heal Alzheimers
5. Exposure To High Aluminum Levels In Tap Water Lead To Rare Form Of Alzheimers
6. Sugar variant may make a world of difference to Alzheimers disease
7. Alzheimers Disease Enzyme may Interfere With Brain Function
8. Emotional Stress Could Be a Factor in Causing Alzheimers: Study
9. Alzheimers Incidence is Set to Quadruple by 2050
10. GAB2-A New Alzheimers Gene Identified
11. Reduced Oxygen to the Brain Increases Alzheimers Risk in Stroke Victims
Post Your Comments:
(Date:6/27/2016)... , ... June 27, 2016 , ... "FCPX editors can ... inside of Final Cut Pro X," said Christina Austin - CEO of Pixel Film ... Final Cut Pro X users can now reveal the media of their ...
(Date:6/27/2016)... Lafayette, California (PRWEB) , ... ... ... a pioneer in the patient payment industry today announced its strategic partnership ... and health system workflows. , The two companies’ proven, proprietary technology combine ...
(Date:6/27/2016)... ... 27, 2016 , ... recently awarded their highest five-star rating to Best ... individuals in the United States and Canada wear eyeglasses. Once considered to be a ... and make a fashion statement. Even celebrities use glasses as a way of creating ...
(Date:6/26/2016)... ... 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic ... World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. ... some of the world’s leading providers of cereal and other breakfast foods. Its residents ...
(Date:6/26/2016)... Cary, North Carolina (PRWEB) , ... June 26, 2016 , ... ... the release of a new product that was developed to enhance the health of ... harvested for centuries. , The two main herbs in the PawPaws Cat Kidney ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016  VMS Rehab Systems, ... Board will take whatever measures required to build a ... stock which is currently listed on the OTC Markets-pink ... Company Chairman and CEO, "We are seeing an anomaly ... to understand, not only by the Company, but shareholders ...
(Date:6/24/2016)... 24, 2016  Global Blood Therapeutics, Inc. (GBT) (NASDAQ: ... novel therapeutics for the treatment of grievous blood-based ... closing of its previously announced underwritten public offering ... public offering price of $18.75 per share. All ... by GBT. GBT estimates net proceeds from the ...
(Date:6/24/2016)... , June 24, 2016 The Academy ... of recommendations that would allow biopharmaceutical companies ... with entities that make formulary and coverage decisions, a ... "value" of new medicines. The recommendations address ... not appear on the drug label, a prohibition that ...
Breaking Medicine Technology: