Navigation Links
New Advances Could Battle Cancer Cell by Cell
Date:10/8/2008

Flow cytometry illuminates signaling protein pathways, study says

WEDNESDAY, Oct. 8 (HealthDay News) -- Breaking complex cancers down to the single-cell level to study the key signaling events needed for the disease to form and progress may hold hope for improved diagnoses and treatments in the future, a new report says.

Researchers studying juvenile myelomonocytic leukemia (JMML) now say taking advantage of recent advances in flow cytometry, a technique that allows detailed examination of individual cells, may allow them to simultaneously measure cell type and signaling pathways.

Their findings were published in the October issue of Cancer Cell.

Flow cytometry helped the researchers profile signaling at the single cell level in young children with JMML, an aggressive disorder that is difficult to diagnose and has a complex molecular profile. The findings included a STAT5 signaling signature in most of the JMML patients, suggesting a critical role for JAK-STAT signaling in the biological mechanism of this cancer and suggesting potential targets for future therapies.

"This work successfully used single-cell profiling to follow patients over time and show that disease status in JMML -- at diagnosis, remission, relapse and transformation -- was indicated by a subset of cells with an abnormal signaling profile," co-lead study author Mignon L. Loh, from the University of California, San Francisco, Children's Hospital and the Helen Diller Family Comprehensive Cancer Center, said in a news release issued by the journal's publisher.

"By measuring how signaling proteins respond to certain stimuli at diagnosis and which are modified by resistant cancers, we are essentially monitoring key highways that cancers use to drive their own growth," co-lead author Garry P. Nolan of Stanford University School of Medicine said in the news release. "The advantage of diagnosing a patient's cancer at the single-cell level provides us an approach for early detection of cancer and yield insights into how cancer cells are responding or adapting to therapy. A byproduct of the single cell technique, when appropriately extended, is that we should eventually be able to predict those pathways cancer cells might be using to circumvent current therapies and more intelligently direct the patient toward alternative treatments."

More information

The National Cancer Institute has more about cancer.



-- Kevin McKeever



SOURCE: Cancer Cell, news release, Oct. 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Ovation further advances development pipeline with new phase III epilepsy study
2. Medical, technological advances prompt updating of nuclear medicine technologists scope of practice
3. Major grant advances UWs clinical and translational research enterprise
4. Plastic Surgery 2007: Where Truth Behind Emerging Cosmetic Treatments Meets Amazing Reconstructive Advances
5. Innovation and Medical Advances to be Highlighted on Final Day of Inaugural AdvaMed 2007 Conference
6. Despite Advances in the Accuracy of CT Colonography in Detecting Polyps, Digestive Health Experts Urge Patients to Consider Risks and Realities
7. Advances in drug screening: building a better haystack for the needles of tomorrow
8. Advances in Cancer Research, Funding Stem Cell Research, and More at Annual Cancer Congress
9. UCLA, Tokyo University nanobiotechnology symposium at UCLA to highlight advances in nanomedicine
10. Springer adds Advances in Therapy to journals portfolio
11. NIH grant advances dentistry schools work on psychosocial stress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/25/2016)... ... , ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter ... bar too high can result in disappointment, perhaps even self-loathing. However, those who set ... , Research from PsychTests.com reveals that behind the tendency to set low ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... Fla. (PRWEB) , ... June 24, 2016 , ... Global ... Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition ... Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this year’s ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Bay Area ... Network,s Dean Center for Tick Borne Illness ... and Rehabilitation, MIT Hacking Medicine, University of California, ... today announced the five finalists of Lyme ... disease.  More than 100 scientists, clinicians, researchers, entrepreneurs, ...
(Date:6/24/2016)... , June 24, 2016 ... of the "Structural Electronics 2015-2025: Applications, Technologies, ... In-Mold Electronics, Smart Skin, ... Photovoltaics Structural electronics involves electronic ... load-bearing, protective structures, replacing dumb structures such as ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical ... the "Company"), which develops, markets and sells medical devices ... , signed a strategic cooperation agreement with Hongyuan ... "Hongyuan Supply Chain") on June 20, 2016, to develop ... the strategic cooperation agreement, Dehaier will leverage Hongyuan Supply ...
Breaking Medicine Technology: