Navigation Links
New 3-D model of RNA 'core domain' of enzyme telomerase may offer clues to cancer, aging
Date:11/4/2010

copies from RNA to DNA.

"Reverse transcriptases normally copy RNA to DNA but do not contain RNA; in this enzyme, the protein requires the RNA component to function.

"Telomerase is unique because the template is part of the enzyme, and it is used to copy one telomere repeat and then starts over and makes another, and another, all attached to one another. That is how telomerase extends the telomeres," she said. "Telomerase has its own internal piece of RNA that is used to copy the DNA, but this 'template' is only approximately 10 of the 451 nucleotides."

Telomerase has been extremely difficult to characterize structurally because of its size and complexity and its low level in normal cells.

Other co-authors on the PNAS paper are Nak-Kyoon Kim, a postdoctoral scholar in Feigon's laboratory; Robert Peterson, a research scientist in Feigon's laboratory; and Zhonghua Wang, a postdoctoral scholar in Feigon's laboratory. This PNAS research is Feigon's inaugural article as a member of the National Academy of Sciences.

Feigon's laboratory studies the 3D structures of DNA and RNA and how proteins and DNA and RNA recognize one another to switch genes on and off in cells. A member of UCLA's faculty since 1985, Feigon was the first UCLA scientist to use NMR to determine DNA and RNA structures. She and her colleagues utilize a range of molecular biological, biochemical and biophysical techniques.

Serendipity often plays a prominent role in science, and this is another example. When Feigon began her research on telomeres and telomerase in the early 1990s, she was not even thinking about cancer. Instead, she was interested in studying DNA structure.


'/>"/>

Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Celebrity Trainer and Super Fitness Model Jennifer Nicole Lee on HSN with #1 Secret Six Pack Abs Secret, Ab Circle Pro
2. Hunk Calendar Photographer Resurrects Erotic Male Modeling Club and Launches Provocative E-exhibition
3. Dolphins could be ideal model to study human cervical cancer, UF veterinarians say
4. David Anderson to discuss what model organisms can teach us about emotion
5. Rate Regulation for Health Insurance: Obama Administration Should Look to CAs Model Law Which Has Saved Drivers $62 Billion Since 1988
6. GE Healthcare, Intel and Mayo Clinic explore new models of health care delivery
7. Rapamycin rescues learning, memory in Alzheimers mouse model
8. Ghrelin mitigates liver fibrosis in animal models; regulates human fibrosis
9. A novel in vitro model for light-induced wound healing
10. Hard to Treat Diseases (HTDS) Collagenna Skin Care Business Model and Chilean Update
11. Choice of Derek H. Lee as Chief Financial and Corporate Development Officer Strengthens Talaris Advisors' Portfolio Design Business Model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... of Medicine (BUSM) have discovered that the anti-seizure ... model. The findings, reported in the American ... lead to more effective treatments for alcoholism. , ... leading causes of illness and death in the ... limiting the productivity of workers and necessitating huge ...
(Date:4/17/2014)... by researchers at UC Davis has shown that the ... in cell division, also boosts the mitochondrial activity to ... complex has been shown to perform both jobs. This ... to control cellular energy production, potentially advancing cancer care ... in the journal Developmental Cell . , "These ...
(Date:4/17/2014)... by Cesar A. Arias, M.D., Ph.D., at The University ... identified a new superbug that caused a bloodstream infection ... April 17 issue of The New England Journal ... of a class of highly-resistant bacteria known as methicillin-resistant ... major cause of hospital and community-associated infections. The superbug ...
(Date:4/17/2014)... days to find a colored ribbon representing a disease. A ... what color ribbon does one think of with lung cancer?, ... many suffering from the disease, black may be the only ... of lung cancer patients, primarily smokers between the ages of ... the stigma often felt by these patients, the emotional toll ...
(Date:4/17/2014)... alleviates muscle soreness after exercise, according to a ... at Chicago. , The study, reported online in ... Physical Medicine and Rehabilitation , also showed that ... not exercised, suggesting that massage has benefits for ... , Improved circulation and relief of muscle soreness ...
Breaking Medicine News(10 mins):Health News:BUSM researchers find anti-seizure drug may reduce alcohol consumption 2Health News:Dual role: Key cell division proteins also power up mitochondria 2Health News:New MRSA superbug emerges in Brazil 2Health News:Unraveling the 'black ribbon' around lung cancer 2Health News:Massage therapy improves circulation, eases muscle soreness 2
... Solta Medical, Inc. (Nasdaq: SLTM ), ... announced that it has received regulatory clearance to market ... excited about the opportunity to market the premier non-invasive ... Republic of China," said Stephen J. Fanning, Chairman of ...
... ProMetic Life Sciences Inc. (TSX: PLI ... announces that it has retained the services of ... subsidiaries of Sumitomo Corporation ("Sumitomo") to advise ProMetic in ... Japanese market.In the course of ProMetic,s partnering activities several ...
... that can cause anal and cervical cancers, is associated with ... men who have sex with men (MSM), according to new ... journal AIDS , the findings are available now. ... , In previous studies, other sexually transmitted infections have been ...
... Wolff today assured Pennsylvanians that the 2009 H1N1 influenza strain ... anywhere in either the U.S. or Mexico, and that pork ... as the ,swine flu, many misconceptions relating to pigs have ... and living near or working on a hog farm is ...
... 30 The Alzheimer,s Association Minnesota-North Dakota in collaboration ... segment of The Alzheimer,s Project on May 12 at ... screening will be followed by a question-and-answer panel of ... for the disease, The Alzheimer,s Project shows there is ...
... Exforge HCT combines a proven calcium channel blocker, ... in one pill - In a clinical trial, ... and diastolic BP, compared to all dual combinations ... patients may need multiple medications to help control ...
Cached Medicine News:Health News:Solta Medical Receives Regulatory Approval to Market Thermage Systems in China 2Health News:Sumitomo to Act As Advisor to ProMetic for Japanese Market 2Health News:Sumitomo to Act As Advisor to ProMetic for Japanese Market 3Health News:Sumitomo to Act As Advisor to ProMetic for Japanese Market 4Health News:Cancer-causing virus associated with higher risk of new HIV infection 2Health News:Pennsylvania Pork Products Safe During H1N1 Flu Outbreak, Says Ag Secretary 2Health News:The Alzheimer's Project HBO Documentary Puts Spotlight On Alzheimer's Disease; Premiere Screening at the Hennepin County Library in Downtown Minneapolis 2Health News:Video: FDA approves Exforge HCT(R) - the Only High Blood Pressure Treatment to Combine Three Medications in a Single Pill 2Health News:Video: FDA approves Exforge HCT(R) - the Only High Blood Pressure Treatment to Combine Three Medications in a Single Pill 3Health News:Video: FDA approves Exforge HCT(R) - the Only High Blood Pressure Treatment to Combine Three Medications in a Single Pill 4Health News:Video: FDA approves Exforge HCT(R) - the Only High Blood Pressure Treatment to Combine Three Medications in a Single Pill 5Health News:Video: FDA approves Exforge HCT(R) - the Only High Blood Pressure Treatment to Combine Three Medications in a Single Pill 6Health News:Video: FDA approves Exforge HCT(R) - the Only High Blood Pressure Treatment to Combine Three Medications in a Single Pill 7
(Date:1/14/2014)... 14, 2014 /PRNewswire-iReach/ -- Acumed,s new SLIC Screw System ... accompanying instrumentation to place and insert the screw accurately ... tissue (e.g. ligament) repair or reconstruction as it holds ... (Photo: http://photos.prnewswire.com/prnh/20140114/MN45636 ) The ...
(Date:1/14/2014)... NuAire , a manufacturer of ergonomically designed laboratory equipment ... of Japan to sell and service the ... NuAire will utilize its network of sales professionals throughout ... to offer assistance in application use, product benefits and features, options ...
(Date:1/14/2014)... VALHALLA, N.Y. , Jan. 14, 2014   Oligomerix, Inc. ... disease modifying therapeutics for Alzheimer,s disease (AD) and related ... headquarters to Valhalla, NY as ... additional laboratory space at New York Medical College. ...
Breaking Medicine Technology:Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3NuAire announces sales and service of Hitachi Koki centrifuges in North America 2Oligomerix Relocates Corporate Headquarters and Secures Additional Laboratory Space from New York Medical College 2
... Texas, May 22, 2012  Prodigy Generics, a division of ... Irinotecan is the generic equivalent of the branded drug ... Pharmaceutical Laboratories to develop a portfolio of oncology products. ... through the partnership that will add consistent supply and ...
... May 22, 2012  MusclePharm Corporation (OTCBB: MSLP.OB), a nutritional ... it has signed Major League Baseball phenom Bryce Harper ... disclosed. Harper, a 19-year-old star outfielder for ... April 28.  He previously was the Number 1 overall ...
Cached Medicine Technology:MusclePharm Signs Pro Baseball Rookie Phenom Bryce Harper As Sponsored Athlete 2
Platinum General Purpose Cautery Electrodes , ,A - Loop Tip, ,Fully autoclavable. Tips typically last for 50 to 100 or more procedures, depending on burn time....
Non-Cantilevered, "Teardrop" Ringed Forceps. ("fixation clamp") For vasectomy and other procedures. Ring ovoid approximately 6.0 mm in diameter....
... Customized stethoscope earmolds add comfort and ... such as ambulance paramedics, Flight-for-Life helicopter personnel, ... ,These molds are specific in design and ... any stethoscope used in today's industry to ...
... Bispectral Index (BIS®) measurement uses Aspect Medical ... of consciousness and sedation monitoring for use ... settings., ,The plug-and-play BISx Power Link™ ... integrated clamp for quick and easy mounting ...
Medicine Products: