Navigation Links
New 3-D model of RNA 'core domain' of enzyme telomerase may offer clues to cancer, aging
Date:11/4/2010

Telomerase is an enzyme that maintains the DNA at the ends of our chromosomes, known as telomeres. In the absence of telomerase activity, every time our cells divide, our telomeres get shorter. This is part of the natural aging process, as most cells in the human body do not have much active telomerase. Eventually, these DNA-containing telomeres, which act as protective caps at the ends of chromosomes, become so short that the cells die.

But in some cells, such as cancer cells, telomerase, which is composed of RNA and proteins, is highly active and adds telomere DNA, preventing telomere shortening and extending the life of the cell.

UCLA biochemists have now produced a three-dimensional structural model of the RNA "core domain" of the telomerase enzyme. Because telomerase plays a surprisingly important role in cancer and aging, understanding its structure could lead to new approaches for treating disease, the researchers say.

"We still do not know how the RNA and the proteins cooperate to do this magical thing -- extend the ends of our telomeres -- but we are now one step closer to understanding that," said Juli Feigon, a UCLA professor of chemistry and biochemistry and senior author of the research, which was published Nov. 2 in the print edition of the Proceedings of the National Academy of Sciences (PNAS).

The critical telomerase RNA core domain is essential for telomerase to add telomere repeats onto the ends of chromosomes, the structures that hold our genes. The core domain contains the template that is used to code for the ends of the chromosomes.

"Telomerase is the most amazing complex," said Feigon, who began studying telomere DNA structure in the early 1990s, which led to her interest in telomerase. "Some people think if we activate telomerase, we can live forever. However, we don't want our cells to be able to divide indefinitely. As they get older and older, they accumulate all k
'/>"/>

Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Celebrity Trainer and Super Fitness Model Jennifer Nicole Lee on HSN with #1 Secret Six Pack Abs Secret, Ab Circle Pro
2. Hunk Calendar Photographer Resurrects Erotic Male Modeling Club and Launches Provocative E-exhibition
3. Dolphins could be ideal model to study human cervical cancer, UF veterinarians say
4. David Anderson to discuss what model organisms can teach us about emotion
5. Rate Regulation for Health Insurance: Obama Administration Should Look to CAs Model Law Which Has Saved Drivers $62 Billion Since 1988
6. GE Healthcare, Intel and Mayo Clinic explore new models of health care delivery
7. Rapamycin rescues learning, memory in Alzheimers mouse model
8. Ghrelin mitigates liver fibrosis in animal models; regulates human fibrosis
9. A novel in vitro model for light-induced wound healing
10. Hard to Treat Diseases (HTDS) Collagenna Skin Care Business Model and Chilean Update
11. Choice of Derek H. Lee as Chief Financial and Corporate Development Officer Strengthens Talaris Advisors' Portfolio Design Business Model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... ... July 30, 2015 , ... Google recently announced that it will ... site. As discussed in a June 8, 2015 article published by Nasdaq , ... have been caused by its computer-driven cars, which such industry players as Tesla CEO ...
(Date:7/30/2015)... ... 30, 2015 , ... 24/7 Care At Home, a high-quality provider of comprehensive ... that the Centers for Medicare and Medicaid (CMS) have awarded its agency the highest ... Care At Home’s agency is one of three top Orange County agencies to earn ...
(Date:7/30/2015)... ... July 30, 2015 , ... ... company and UCLA’s Jonsson Comprehensive Cancer Center (JCCC) mutually agreed to ... new collaboration, OncLive’s editorial and marketing groups will help spread the news about ...
(Date:7/30/2015)... ... July 30, 2015 , ... Glidewell Laboratories, ... issue of Inclusive™ magazine, its multimedia publication focused on implant dentistry, is now ... new issue, Volume 6, Issue 2, as well as past issues of the ...
(Date:7/30/2015)... FL (PRWEB) , ... July 30, 2015 , ... On ... than $2 billion in taxpayer money to fund the state’s large prison system, which ... country with the highest rates of incarceration. In light of President Obama’s recent reduction ...
Breaking Medicine News(10 mins):Health News:New Google Policy on Reporting Driverless Auto Accidents Points Out Growing Complexity of Personal Injury Law in the 21st Century, Says Law Offices of Burg and Brock 2Health News:New Google Policy on Reporting Driverless Auto Accidents Points Out Growing Complexity of Personal Injury Law in the 21st Century, Says Law Offices of Burg and Brock 3Health News:24/7 Care At Home Earns a 5-Star Rating from the Centers for Medicare and Medicaid (CMS) 2Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 2Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 3Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 4Health News:Glidewell Laboratories Puts Out Latest Issue of Dental Implant Magazine Inclusive™ 2Health News:Glidewell Laboratories Puts Out Latest Issue of Dental Implant Magazine Inclusive™ 3Health News:Glidewell Laboratories Puts Out Latest Issue of Dental Implant Magazine Inclusive™ 4Health News:Florida Questions Its Spending on Punitive Incarceration in Light of Exorbitant Costs for Non Violent Offenders 2Health News:Florida Questions Its Spending on Punitive Incarceration in Light of Exorbitant Costs for Non Violent Offenders 3
... elementary schools and earlier studies on teenagers and adolescents ... than those who don't. Doctors in the Massachusetts General ... the academic and emotional functioning of more than 100 ... in addition to improving their psychological dimensions also improved ...
... foundation of diabetics care is the regular monitoring of ... do not adhere to this routine because of inconvenience ... be taken by puncturing// their fingers or forearm. However, ... non-invasive test, using optical coherence tomography, which will end ...
... A recent study published in the British Medical Journal suggests ... the birth weight of their offspring. In contrast to overweight ... men with// diabetes are likely to weigh less than other ... on an average 186 grams less than other children and ...
... people who have periodontal disease and lose a lot of ... aren't sure about the relationship between fewer teeth and higher// ... on 41,376 men found that men with fewer teeth generally ... older and were more likely to smoke, all of which ...
... A study that looked at fertility in male mountain bikers ... reduce a man's fertility. While previous studies have associated the ... whether there //was a link between reduced fertility & the ... mountain bikers and 30 non-bikers, wherein extreme bikers were classified ...
... have a high Body Mass Index (BMI) or simply stated, ... of developing cardiovascular diseases. However a recent study by a ... patients who are 75 and over), with a BMI of ... death from cardiovascular diseases. ,The study entitled " The ...
Cached Medicine News:Health News:Want to have a nice day? Eat breakfast! 2
(Date:7/30/2015)... 30, 2015  Cleveland Clinic President Wael Barsoum ... last month that industry is compelled to adopt declining ... the efficiencies—and develop the transformational innovations -- required to ... were preceded by Doug Kohrs , past President ... who stressed that industry must add "episode of care," ...
(Date:7/30/2015)... July 30, 2015 ... report with market overview, trends, DRO analysis, ... analysis, recent developments, competitive scenario and top ... Insight: Biosensors Market Development and Demand Forecast ... http://photos.prnewswire.com/prnh/20150727/756778 ) Explore more about ...
(Date:7/30/2015)... July 30, 2015 Vermillion, Inc. ... gynecologic disease, announced today it will report ... the market close on Thursday, August 13, ... and webcast at 4:30pm Eastern.Conference Call and ... 4:30pm Eastern/1:30pm Pacific  Domestic: , ...
Breaking Medicine Technology:Orthopaedic Surgery Reimbursement Shifts to Episode of Care 2Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 2Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 3Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 4Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 5
... $5 Million Payment from Roche- , , ... (Nasdaq: MEMY ) today announced that it has ... R3487/MEM 3454, its lead alpha-7 nicotinic receptor agonist, in cognitive ... 212 patients in the Phase 2 trial, triggering a $5.0 ...
... MALVERN, Pa., Nov. 18 Arlington Medical Resources (AMR), ... diagnostic,imaging industries, finds that over $10 million of CSL ... quarter of 2008. Privigen is the newest,brand of intravenous ... of 2008. IVIG is a product created from the ...
Cached Medicine Technology:Memory Pharmaceuticals Achieves Enrollment Goal for Phase 2 Study of MEM 3454 in Cognitive Impairment Associated With Schizophrenia 2Memory Pharmaceuticals Achieves Enrollment Goal for Phase 2 Study of MEM 3454 in Cognitive Impairment Associated With Schizophrenia 3Over $10 Million of CSL Behring's Privigen Was Sold in the U.S. During the Third Quarter of 2008 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: