New, simple method identifies preterm infants at risk of e...( A simple way of establishing which p...),Health

A simple way of establishing which preterm infants are at risk of developing the eye disease ROP is to follow their weight gain. A new study from the Sahlgrenska Academy, University of Gothenburg, Sweden, suggests that following weekly weight development might replace the need for considerably more expensive ophthalmological examinations.

Every year around 1000 Swedish infants are born more than two months prematurely. Preterm infants are at increased risk of damage to several important organs, including the brain, lungs, guts and eyes. Around 350 of these infants develop the eye disease retinopathy of prematurity (ROP) which, if left untreated, can threaten their sight. Ten per cent, or around one hundred, of the preterm infants need the same treatment to prevent blindness.

"In the past 50 years it has been routine for all infants born very prematurely to be examined several times by ophthalmologists to identify children who need treatment for ROP, but this expensive method of screening can now perhaps be replaced by a considerably simpler and cheaper method, so that ophthalmological examination can be avoided in most cases," says Professor Ann Hellstrm of Sahlgrenska Academy.

The research team has previously identified another important link between preterm birth and vascular disease in the eye, the protein IGF-1, which is strongly linked to the infant's weight gain. Assisted by statisticians at the University of Gothenburg, the researchers have developed an assessment model known as WINROP (Weight IGF-1 Neonatal ROP), which is based on weekly measurements of the infant's weight and analyses of the serum levels of IGF-1. "However, one would prefer not to take any blood samples from the preterm infants, and therefore we wanted to investigate whether our surveillance model worked if we only used the infant's weight. We found that it works extremely well," says Professor Hellstrm.

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