Navigation Links
New, 'robust' treatment for stroke uses genetic material from bone marrow
Date:8/26/2013

DETROIT In the latest in a series of experiments testing the use of stem cells to treat neurological disease, researchers at Henry Ford Hospital have shown for the first time that microscopic material in the cells offers a "robust" treatment for crippling stroke.

"In this study we pioneered a totally new treatment for stroke, and possibly for all neurological disease," says Michael Chopp, Ph.D., scientific director of the Henry Ford Neuroscience Institute.

The new study is published online in the current issue of Journal of Cerebral Blood Flow and Metabolism.

It focused on exosomes, blister-like microscopic "bubbles" that once were thought to carry and get rid of "old" proteins that were no longer needed by the body. After they were recently found to also carry RNA, whole new fields of study were suggested including the pioneering work at Henry Ford.

The research team found that after inducing stroke in lab rats, injecting exosomes containing this genetic material into their blood prompted remodeling of the affected brain, including increased production of new brain cells, blood vessels and neural rewiring. Together, these effects significantly improved neurological function that had been impaired by stroke.

Using bone marrow from the adult rats, the researchers extracted stem cells specifically mesenchymal cells, or MSCs that were then employed to generate exosomes.

The researchers induced stroke by occluding an artery in the brain of each rat to block blood flow for two hours. Twenty-four hours later, they injected the exosomes into a vein in each rat's tail.

The rats' physical agility and neurological responses were tested before stroke and after treatment with the exosomes, and the results were compared.

"All rats showed severe functional loss one day after treatment, but gradual and eventually significant improvement during the four-week period that followed," Dr. Chopp says. "This discovery provides a novel treatment for stroke, and possibly other neurological diseases."

Dr. Chopp and Henry Ford researchers earlier found that the beneficial effects of treatment of stroke with bone marrow cells are attributed to their production and release of exosomes. In addition, using a similar treatment with exosomes from bone marrow stem cells significantly reduced a particularly resistant form of malignant brain tumor in living lab rats.


'/>"/>

Contact: Dwight Angell
dwight.angell@hfhs.org
313-850-3471
Henry Ford Health System
Source:Eurekalert

Related medicine news :

1. Low-Temperature Benchtop Chillers Provide Robust Cooling for Laboratory Equipment
2. Researchers confirm multiple genes robustly contribute to schizophrenia risk in replication study
3. New York Plastic Surgeon Offers New Microcannula Technique Injectable Treatments; Dr. Ran Y. Rubinstein Announces Addition of DermaSculpt as an Alternative to Needles
4. Har Vokse - Hair Regrowth Treatment Product For Men and Women Now Comes with 2 Month Extra Supply On Every Purchase!
5. Researchers from Mount Sinai receive NIH grant to study promising treatment for Autism subtype
6. SclerosisTreatment.com Reveals How to Cure MS Using Natural Multiple Sclerosis Treatment
7. Yardley, PA Gum Disease Treatment Can Potentially Prevent Tooth Loss Using Laser Gum Surgery with Dr. Edward Marcus of Floral Vale Periodontics & Implants
8. Park Cities Aesthetics Announces New Treatment Option
9. Gulf Coast Spine Care Introduces Enhanced Sciatica Treatment Options
10. San Diego Dermatologist Discusses Most Effective Treatment for Pearly Penile Papules (PPP)
11. Single injection may revolutionize melanoma treatment, Moffitt study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... ... 2017 , ... The 89th Academy Awards will be celebrated this weekend, which ... Center Bunkum Award. We invite you to enjoy our 11th annual tongue-in-cheek “salute” to ... the Center for American Progress (CAP), for its report, Lessons From State Performance on ...
(Date:2/23/2017)... ... 2017 , ... The American Cleft Palate-Craniofacial Association (ACPA) is pleased to announce ... a longtime supporter of the event. , "We are pleased that KLS Martin is ... Havlik, 2017 ACPA President. "KLS Martin has a long track record of support of ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... leadership , media relations, content marketing, social media management, corporate communications, SEO and ... in the state and in nearby New Hampshire, Massachusetts and Canada, Rosica will ...
(Date:2/23/2017)... ... , ... Dr. David Mahon leads Siena Dental, a comprehensive dental practice located ... 2017 Top Patient Rated Henderson Dentist by Find Local Doctors earlier this ... and dentists who have earned high ratings and superior patient reviews from multiple credible ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... today that it will soon begin franchising throughout the U.S. starting this spring. ... help bring the practice of meditation mainstream. Current Meditation will be the first ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... Calif. , Feb. 23, 2017 ... company focused on the development and commercialization of ... pain, announced that it will release fourth quarter ... Thursday, March 2nd, 2017. AcelRx management will host ... Time (1:30 p.m. Pacific Time) on March 2 ...
(Date:2/23/2017)... 2017 Obese people are seldom ... varicose veins in their body. The rising number of ... adoption of endovenous laser therapy for treatment of varicose ... therapy market, published by Future Market Insights, indicates ... consequences of obesity have collectively factored the growth in ...
(Date:2/23/2017)... , Feb 23, 2017 Research and ... Analysis & Trends - Industry Forecast to 2025" report to ... ... of around 6.9% over the next decade to reach approximately $47.6 ... market estimates and forecasts for all the given segments on global ...
Breaking Medicine Technology: