Navigation Links
New, 'robust' treatment for stroke uses genetic material from bone marrow
Date:8/26/2013

DETROIT In the latest in a series of experiments testing the use of stem cells to treat neurological disease, researchers at Henry Ford Hospital have shown for the first time that microscopic material in the cells offers a "robust" treatment for crippling stroke.

"In this study we pioneered a totally new treatment for stroke, and possibly for all neurological disease," says Michael Chopp, Ph.D., scientific director of the Henry Ford Neuroscience Institute.

The new study is published online in the current issue of Journal of Cerebral Blood Flow and Metabolism.

It focused on exosomes, blister-like microscopic "bubbles" that once were thought to carry and get rid of "old" proteins that were no longer needed by the body. After they were recently found to also carry RNA, whole new fields of study were suggested including the pioneering work at Henry Ford.

The research team found that after inducing stroke in lab rats, injecting exosomes containing this genetic material into their blood prompted remodeling of the affected brain, including increased production of new brain cells, blood vessels and neural rewiring. Together, these effects significantly improved neurological function that had been impaired by stroke.

Using bone marrow from the adult rats, the researchers extracted stem cells specifically mesenchymal cells, or MSCs that were then employed to generate exosomes.

The researchers induced stroke by occluding an artery in the brain of each rat to block blood flow for two hours. Twenty-four hours later, they injected the exosomes into a vein in each rat's tail.

The rats' physical agility and neurological responses were tested before stroke and after treatment with the exosomes, and the results were compared.

"All rats showed severe functional loss one day after treatment, but gradual and eventually significant improvement during the four-week period that followed," Dr. Chopp says. "This discovery provides a novel treatment for stroke, and possibly other neurological diseases."

Dr. Chopp and Henry Ford researchers earlier found that the beneficial effects of treatment of stroke with bone marrow cells are attributed to their production and release of exosomes. In addition, using a similar treatment with exosomes from bone marrow stem cells significantly reduced a particularly resistant form of malignant brain tumor in living lab rats.


'/>"/>

Contact: Dwight Angell
dwight.angell@hfhs.org
313-850-3471
Henry Ford Health System
Source:Eurekalert

Related medicine news :

1. Low-Temperature Benchtop Chillers Provide Robust Cooling for Laboratory Equipment
2. Researchers confirm multiple genes robustly contribute to schizophrenia risk in replication study
3. New York Plastic Surgeon Offers New Microcannula Technique Injectable Treatments; Dr. Ran Y. Rubinstein Announces Addition of DermaSculpt as an Alternative to Needles
4. Har Vokse - Hair Regrowth Treatment Product For Men and Women Now Comes with 2 Month Extra Supply On Every Purchase!
5. Researchers from Mount Sinai receive NIH grant to study promising treatment for Autism subtype
6. SclerosisTreatment.com Reveals How to Cure MS Using Natural Multiple Sclerosis Treatment
7. Yardley, PA Gum Disease Treatment Can Potentially Prevent Tooth Loss Using Laser Gum Surgery with Dr. Edward Marcus of Floral Vale Periodontics & Implants
8. Park Cities Aesthetics Announces New Treatment Option
9. Gulf Coast Spine Care Introduces Enhanced Sciatica Treatment Options
10. San Diego Dermatologist Discusses Most Effective Treatment for Pearly Penile Papules (PPP)
11. Single injection may revolutionize melanoma treatment, Moffitt study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and ... their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took ... the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published ... unfamiliar with. The article goes on to state that individuals are now more comfortable ... less common operations such as calf and cheek reduction. The Los Angeles area medical ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... June ... about the dangers associated with chronic pain and the benefits of holistic treatments, ... individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of ... AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
(Date:6/23/2016)... June 23, 2016 The vast majority of ... dialysis facility.  Treatments are usually 3 times a week, ... visit, including travel time, equipment preparation and wait time. ... especially grueling for patients who are elderly and frail.  ... nursing and rehabilitation centers for some duration of time. ...
Breaking Medicine Technology: