Navigation Links
New, noninvasive, stool-based colorectal cancer screening test

(New York, March 19, 2014) A new, non-invasive, stool-based screening test detected 92% of colorectal cancer (CRC), according to a multicenter trial published online today in the New England Journal of Medicine. The new test, which is not yet approved by the FDA, allows patients to collect a sample at home without the need for bowel preparation or diet restrictions.

Unlike other available stool-based CRC screening tests, which rely solely on detecting occult blood in the stool, this new test, called "Cologuard", developed and patented by Exact Sciences, detects both occult blood and abnormal DNA that is shed by polyps and cancers. Although a colonoscopy is the preferred CRC screening method in most of the United States, about 30-35% of individuals do not get screened. Until now, stool-based CRC screening tests that were based on detecting occult blood in the stool had many false-positives and false-negatives; not all blood in the stool is from a polyp or cancer, and not all cancers bleed enough to be detected.

"This test is done in the privacy of your home, on a single specimen, and shipped directly to the lab without the need for freezing the sample," says Steven Itzkowitz, MD, a trial investigator and Professor of Medicine and Director of the Gastroenterology Fellowship Program at the Icahn School of Medicine at Mount Sinai.

In the study, participants submitted a stool sample for a commercial occult blood fecal immunochemical test (FIT) as well as for the new multi-target stool DNA test. Everyone then had a colonoscopy as the gold-standard comparator. All enrollees were considered "average-risk", meaning they were asymptomatic men and women 50 years or older, the segment of the population recommended for colorectal cancer screening. Data published today includes that the test detected 92% of colorectal cancer in patients versus FIT's 74%. The test also detected 42% of advanced pre-cancerous lesions in patients as compared to 24% for FIT.

The test might also be useful as an 'interval' look between colonoscopies to make sure lesions are not developing before the next scheduled colonoscopy for higher-risk individuals who are advised to get more frequent colonoscopies.

Dr. Itzkowitz is on the Scientific Advisory Board of Exact Sciences Corporation.

This study was funded by Exact Sciences Corporation.

Other authors include experts from Indiana University, University of North Carolina, Mayo Clinic Rochester, MN; Kaiser Permanente Medical Center, Walnut Creek, California; Boston Biostatistics Research Foundation, Boston, MA; and Exact Sciences Corporation, Madison, WI.

The Cologuard test is limited to investigational use only and is not available for sale in the United States.


Contact: Johanna Younghans
The Mount Sinai Hospital / Mount Sinai School of Medicine

Related medicine news :

1. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
2. Study says screening accounts for much of black/white disparity in colorectal cancer
3. Blacks and Hispanics at higher risk for precancerous colorectal polyps
4. Geisel researchers sift through junk to find colorectal cancer clues
5. Blood pressure drugs dont protect against colorectal cancer
6. NIH study finds sigmoidoscopy reduces colorectal cancer rates
7. Colonoscopy screening markedly reduces colorectal cancer incidence and death
8. Surgical patient safety program lowers SSIs by one-third following colorectal operations
9. A recipe for increased colorectal cancer screening rates
10. Gene mutation identifies colorectal cancer patients who live longer with aspirin therapy
11. New electrically-conductive polymer nanoparticles can generate heat to kill colorectal cancer cells
Post Your Comments:
(Date:11/29/2015)... (PRWEB) , ... November 29, 2015 , ... While conventional ... kneeling or provide ready access to exercise weights. Fortunately, an inventor from Uniontown, Pa., ... THE TOMMY WALKER to enhance the benefits of a standard walker to improve the ...
(Date:11/29/2015)... ... November 29, 2015 , ... Key Housing, a top-rated corporate ... their December, 2015, featured apartment community: Epic. In showcasing this featured apartment community in ... tight Bay Area rental market to efficiently find housing suitable to their needs by ...
(Date:11/28/2015)... ... 28, 2015 , ... Beginning November 30th at 6:00 a.m. EST until 11:59 p.m. EST, ... possible savings of up to 20% off orders $80 or more to free gifts with ... few hours. , As a competitive e-commerce website for skin care and cosmetic needs, customers ...
(Date:11/27/2015)... CA (PRWEB) , ... November 27, 2015 , ... According ... carried out by the University of Toronto and the University of British Columbia suggested ... hospitalizations for head injuries. The article explains that part of the reason for the ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... a safe and convenient way to dispense prescription medications at home, so he ... effective way to monitor and dispense prescription medications. In doing so, it could ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Sectra (STO: SECT B) ... into a multi-year agreement to provide Breast Imaging PACS ... Breast Care to increase collaboration with sub-specialists around the ... --> Sectra (STO: SECT B) ... into a multi-year agreement to provide Breast Imaging PACS ...
(Date:11/29/2015)... AMSTERDAM , Nov. 29, 2015  Strengthening its ... (NYSE: PHG, AEX: PHIA) today announced IntelliSpace Portal ... sharing, analytics and visualization platform that helps radiologists detect, ... the 2015 Radiological Society of North America Annual ... , IntelliSpace Portal 8.0 helps address the changing demands ...
(Date:11/29/2015)... Nov. 29, 2015   Royal Philips  (NYSE: PHG, ... solutions at the 2015 Radiological Society of North America ... McCormick Place in Chicago . Visitors ... the company,s broad portfolio of integrated Diagnostic Imaging, Clinical ... increase clinical performance, improve workflow and create a superior ...
Breaking Medicine Technology: