Navigation Links
Nevirapine-based treatment is effective in African women, but not optimal
Date:6/12/2012

Boston, MAAccording to new research from Brigham and Women's Hospital (BWH), an anti-AIDS treatment regimen, which includes the WHO-recommended drug nevirapine, is just as effective at suppressing the HIV virus as lopinavir/ritonavir, which is more expensive. The study is published in the June 12 issue of PLoS Medicine.

These findings are reassuring as they confirm the 2010 recommendation from the World Health Organization (WHO) that initial treatment of HIV-infected women, in resource-limited settings, should be a nevirapine based regimen. This particular combination is rapidly becoming one of the most commonly used antiretroviral treatment regimens worldwide, particularly among women. However, minimal data regarding the efficacy of this combination existed before this study and earlier data raised concerns about the potency of this regimen.

The researchers, led by Shahin Lockman, MD, a physician-researcher in the Division of Infectious Diseases at BWH, conducted one of the larger treatment studies in HIV infected women, worldwide. They analyzed 500 HIV-infected women in Africa who had not previously taken any antiretroviral treatment but who were found to have advanced HIV disease and required treatment. Half of the women received an antiretroviral therapy which contained nevirapine, and the other half received the antiretroviral therapy which contained lopinavir/ritonavir, which is much more expensive and is reserved for second-line treatment in resource limited settings.

The researchers found that the two treatment regimens were equally as effective in suppressing the HIV virus and keeping people alive. However, the major difference in the two treatments was that 14 percent of the women in the nevirapine group stopped treatment because of adverse health effects. None of the women in the lopinavir/ritonavir group stopped treatment.

"Our findings show that the nevirapine based regime is potent and effective, just not optimal," explained Lockman.

Overall, while the study provides some reassurance regarding effectiveness, the results reinforce that other better-tolerated regimes should be sought after and used where possible.

"The take away message of our study should be that while this regimen works, it's not the best that we could be using and we need to continue to press for better access to better regimes," Lockman added.


'/>"/>

Contact: Jessica Maki
jmaki3@partners.org
617-534-1603
Brigham and Women's Hospital
Source:Eurekalert

Related medicine news :

1. Smoking negatively affects response to anti-TNF treatment in patients with rheumatoid arthritis
2. Depressed Teens Who Respond to Treatment Less Likely to Abuse Drugs
3. Personalizing biologic treatment to individual patients with rheuatoid arthritis is cost-effective
4. Control of disease activity and biologic treatment increase life expectency in RA patients
5. Treatment with anti-TNFs can increase the risk of shingles by up to 75 percent
6. Pre-op Treatments Boost Survival for Esophageal Cancer Patients: Study
7. LA BioMeds Dr. Patricia Dickson researching treatments for neurodegenerative disorders
8. Hear to see: New method for the treatment of visual field defects
9. Injection of methotrexate not superior to oral therapy in juvenile arthritis treatment
10. Antioxidant shows promise as treatment for certain features of autism, Stanford study finds
11. Antiretroviral treatment for preventing HIV infection: an evidence review for physicians
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment ... Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This ... of the world’s leading providers of cereal and other breakfast foods. Its residents often ...
(Date:6/26/2016)... Cary, North Carolina (PRWEB) , ... June 26, 2016 , ... ... the release of a new product that was developed to enhance the health of ... harvested for centuries. , The two main herbs in the PawPaws Cat Kidney ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can now ... and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings ... The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the ...
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
(Date:6/23/2016)... Research and Markets has announced the addition ... States, China, Japan, Brazil, United Kingdom, Germany, France, Italy, ... Surgical Procedure Volumes: Global ... surgical procedure volume data in a geographic context. The ... of growth drivers and inhibitors, including world population growth, ...
(Date:6/23/2016)... YORK , June 23, 2016 ... waters, but it continues to present great opportunities to ... companies for today: Intrexon Corp. (NYSE: XON ... Arena Pharmaceuticals Inc. (NASDAQ: ARNA ), and ... more about these stocks and receive your complimentary trade ...
Breaking Medicine Technology: