Navigation Links
Neurosurgery publishes findings of 3 important studies in June issue
Date:6/19/2013

Philadelphia, Pa. (June 19, 2013) The results of three important studies have been published in the June issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

One study indicates that continuous "machine learning" using artificial neural networks (ANNs) may improve the ability to predict survival in patients with advanced brain cancers. Another study in the June Neurosurgery supports increased use of stereotactic biopsy for obtaining samples of brainstem tumors; while another calls for medical professionals and specialty societies to play an increased role in evaluating "off label" uses of medications.

Artificial Neural Networks Predict Brain Cancer Prognosis

Dr. Matthew Ewend of University of North Carolina and colleagues evaluated the use of ANNs to predict the chances of survival for patients with brain cancer. Based on the biological functioning of brain cells, ANNs are computer programs designed "to learn patterns within a data set and then apply that learning for recognition and prediction."

The researchers performed a pilot study of ANNs using data on patients treated for advanced brain cancer at several hospitals. The results showed that ANNs beat standard prediction models for predicting patient survival. "Pooled voting" of five ANNs correctly predicted the risk of death within one year in 84 percent of patients, compared to 78 percent with a single ANN and 74 percent using standard statistical techniques.

The predictive power of ANNs would likely increase over time, providing a "facile and powerful means or predicting survival" in patients with brain cancers or other conditions. The researchers conclude, "With the explosion in clinical data over the past few years.we anticipate a growing need for modern machine learning techniques such as ANNs to properly make use of the information at our disposal and realize its full benefit for clinical care."

New Proposal for Evaluating 'Off Label' Uses of Medications

An improved process for evaluating "off label" use of drugsusing medications for purposes other than those for which they were approvedis described by Donlin Long, MD, PhD, of Johns Hopkins School of Medicine and Clark Watts, MD, JD, of University of Texas School of Law. They cite the example of bone morphogenetic protein-2 (BMP-2), a product approved to promote bone growth in one specific type of spinal fusion surgery.

After approval, surgeons started using BMP-2 for various other types of spinal surgeryleading to complications in some cases. The authors believe that problems resulting from "uncontrolled" off-label use have had a chilling effect, leading to missed opportunities to develop effective uses of BMP-2.

In the proposed approach, medical specialty societies such as the Congress of Neurological Surgeons would play a leading role in setting parameters for off-label use of new products, and in systematically gathering evidence of effectiveness. Drs. Long and Watts write, "Our goal is to challenge our professional societies to take a leadership role in the study of valid uses of new drugs and devices in a cooperative, constructive relationship with government regulators and industry."

Stereotactic Biopsy for Brainstem Tumors

Dr. Philipp Kickingereder of University Hospital of Cologne and colleagues present a review of research evidence on stereotactic biopsyusing triangulation techniques to precisely localize tumorsto obtain samples of uncommon brainstem cancers. While stereotactic biopsy is not a new technique, surgeons may hesitate to use it for brainstem tumors because of the perceived risks of the procedure.

But the available data show a diagnostic success rate of 96 percent, with a relatively low complication rates. Dr. Kickingereder and coauthors conclude that stereotactic biopsy is a safe and valuable procedure that provides samples for simultaneous tissue and genetic analysiswhich may allow more individualized treatment. They recommend its use in all adult patients with brainstem cancers, as well as in certain groups of children.


'/>"/>

Contact: Connie Hughes
connie.huges@wolterskluwer.com
646-674-6348
Wolters Kluwer Health
Source:Eurekalert

Related medicine news :

1. No July phenomenon for neurosurgery patients, reports Neurosurgery
2. Virtual reality simulator helps teach surgery for brain cancer, reports Neurosurgery
3. Limiting neurosurgery residents work hours hasnt decreased complication rates
4. Virtual reality and robotics in neurosurgery -- promise and challenges
5. No need for routine repeated CT scans after mild head trauma, reports neurosurgery
6. New biomarker may help in detecting gliomas, reports Neurosurgery
7. SomaLogic publishes proteomic biomarker analysis of lung cancer tissue samples
8. Moffitt researcher publishes book on nutritional management of cancer treatment effects
9. Ear, Nose & Throat Journal publishes research on breakthrough treatment for tonsil stones
10. Natural Sciences Repository Publishes Chromatography and Acidic Compounds Resources
11. ASTRO publishes Safety is No Accident: A Framework for Quality Radiation Oncology and Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
(Date:6/24/2016)... ... ... makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum ... by 2020 and then adjusting it yearly to increase at the same rate as the ... wage floor does not erode again, and make future increases more predictable. , The company ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... actively feeding the Frederick area economy by obtaining investment capital for emerging technology ... past 2½ years that have already resulted in more than a million dollars ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 2016 Research and Markets has ... by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), ... Parenteral) - Global Forecast to 2021" report to ... The global pharmaceutical excipients market is projected to reach ... 6.1% in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: