Navigation Links
Neuroscientists show insulin receptor signaling regulates structure of brain circuits
Date:6/18/2008

A team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has demonstrated for the first time in living animals that insulin receptors in the brain can initiate signaling that regulates both the structure and function of neural circuits.

The finding suggests a significant role for this class of receptors and perhaps for insulin, not only in brain development, but also in cognition and in pathological processes in which cognition is impaired, as in Alzheimer's disease, for example.

Insulin receptors on the surface of cells throughout the body have long been understood to play a central role in controlling metabolism through the regulation of glucose. When a molecule of insulin, a hormone, "docks" with the receptor, a complex signaling cascade is set in motion inside a cell, culminating in the cell's uptake of insulin.

The Brain Is Not "Insulin-Insensitive" After All

Although insulin receptors are observed in certain parts of the mammalian brain, most scientists, until a few years ago, had assumed the organ was "insulin-insensitive," knowing that glucose could be taken up by brain cells without the involvement of either insulin or insulin receptors.

In recent years, however, it has been shown that the brain is indeed an insulin target, and in cell-culture experiments that insulin receptor signaling in neurons can have an impact on the formation and development of neural circuits. This had never been demonstrated in living organisms until it was shown in experiments performed in the laboratory of CSHL Professor Hollis Cline, Ph.D., and reported this week in the journal Neuron.

These experiments, in Xenopus tadpoles, show that insulin receptor signaling in neurons regulates the maintenance of synapses, contributes to the processing of sensory information and is also involved in adjusting the plasticity of brain circuits in response to experience. The latter function is particularly int
'/>"/>

Contact: Jim Bono
bono@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. QBI neuroscientists make Alzheimers disease advance
2. Jefferson neuroscientists find early lead exposure impedes recovery from brain injury
3. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
4. Insulin Resistance Tied to Peripheral Artery Disease
5. Some patients may not need insulin for long-term control of type 2 diabetes
6. Novel mechanisms controlling insulin release and fat deposition discovered
7. Photo: Introduction of the Amigo Insulin Pump Offers a Lifestyle Where Life Has No Limits
8. Aspirin-like compounds increase insulin secretion in otherwise healthy obese people
9. Disturbed regulation of insulin production
10. New nanotube sensor can continuously monitor minute amounts of insulin
11. How Patients Can Meet the Criteria for Insulin Pump Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... US (PRWEB) August 01, 2014 Register to ... one of the most active years on record for life ... in life sciences represented 22 percent of all venture dollars ... exits and achieved high valuations. , However, 2014 is ... a recent report by Silicon Valley Bank, while life sciences ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 The ... important developments about chemical listings, appellate decisions, litigation ... that may affect compliance with California's Proposition 65. ... to the law, regulations, history and trends impacting ... the fourth installment of the series which adds ...
(Date:7/31/2014)... have asthma, you may have an asthma action plan with ... to changes and understand when symptoms are getting worse and ... doing well, yellow means your asthma has worsened and action ... guidelines are now available to help your allergist steer you ... from the red zone. , "Management of acute loss of ...
(Date:7/31/2014)... 2014 Developer Jamestown, L.P., has been ... Ponce City Market project in Atlanta’s Old Fourth Ward, ... Company building into best-in-class office, housing, and retail spaces. ... experience with their construction webcam service to assess how ... a construction camera for monitoring and documentation ...
(Date:7/31/2014)... Hoping to attract new customers who are looking ... NutriGold is ready to ship out free samples of product. ... of this offer fast and easy: http://www.nutrigold.com/Free-Samples , ... NutriGold, "We know that every time customers purchase one of ... asset: their own health or the health of a loved ...
Breaking Medicine News(10 mins):Health News:Register to Join the Merrill DataSite's Webinar - Built to Sell: The Life Sciences Deal Climate 2Health News:Register to Join the Merrill DataSite's Webinar - Built to Sell: The Life Sciences Deal Climate 3Health News:Save 25% on the Proposition 65 Handbook - 2013 Edition Through August 31 2Health News:OxBlue Construction Webcam Proves Valuable Tool for Developer, Consumers on Historic Ponce City Market Project 2Health News:OxBlue Construction Webcam Proves Valuable Tool for Developer, Consumers on Historic Ponce City Market Project 3Health News:NutriGold Launches Product Samples Page for its Supplements 2Health News:NutriGold Launches Product Samples Page for its Supplements 3
... published in the July issue of the Journal of ... subset of surgical residents consider duty hour regulations (DHR) a ... for flexibility to work longer hours than current restrictions allow. ... to address resident fatigue and improve patient safety. Prior to ...
... PROVO, Utah, July 14 Nu Skin Enterprises, (NYSE: ... honored yesterday with the International Stevie Award as the top chairman ... Business Awards are the only global, all-encompassing business awards program honoring ... the company,s largest revenue year ever. , , ...
... , MADISON, N.J., July 14 Wyeth Consumer ... announced the availability of a new, scientifically advanced, gender- and age-specific ... women and men. Centrum ((R)) Ultra Women,s and Men,s ... are specially formulated taking into account recommendations established by the Institute ...
... ... nation,s foremost foreign physician immigration expert and senior partner at the Pederson Immigration Law ... Immigration Conference and Job Fair Series. , ... Washington, DC (PRWEB) July 14, 2009 - The Pederson Immigration ...
... Interventional Radiology Coding Users, Guide, a comprehensive resource ... now available in both book and CD formats. ... Society of Interventional Radiology, a national organization of ... improving public health through disease management and minimally ...
... VIENNA, July 14 Eating a "heart healthy" diet and ... our memory and thinking abilities as we age, according to new ... Alzheimer,s Disease (ICAD 2009) in Vienna. , ... ) , , ...
Cached Medicine News:Health News:Survey finds surgical residents view duty hour regulations as a hindrance to training 2Health News:Nu Skin Chairman Recognized With 2009 International Award for Outstanding Business Performance 2Health News:Nu Skin Chairman Recognized With 2009 International Award for Outstanding Business Performance 3Health News:Wyeth Consumer Healthcare Announces the Availability of New Centrum Ultra Line of Multivitamins Specially Formulated For Women and Men 2Health News:Wyeth Consumer Healthcare Announces the Availability of New Centrum Ultra Line of Multivitamins Specially Formulated For Women and Men 3Health News:Pederson Immigration Law Group Attorneys Featured in 14th Annual J-1/H-1B Foreign Physician Immigration Conference and Job Fair Series 2Health News:Pederson Immigration Law Group Attorneys Featured in 14th Annual J-1/H-1B Foreign Physician Immigration Conference and Job Fair Series 3Health News:New: Interventional radiology coding users' guide 2Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 2Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 3Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 4Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 5Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 6Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 7Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 8
(Date:7/31/2014)... July 31, 2014  Decision Resources Group,s ... about by the Affordable Care Act (ACA), ... of pharmaceutical therapies. The ACA altered how ... new regulations and expanded access via government-supported ... health exchanges—state-based marketplaces set up by states ...
(Date:7/31/2014)... 2014  A substantial share of pharmacy and ... therapies are included in formularies—say patient support resources ... new Manhattan Research study, Taking the Pulse® ... that P&T committee members in hospitals, managed care ... set a high bar for these programs, requiring ...
(Date:7/31/2014)... -- Lazarus Effect, a medical device company focused on ... of blood clots, announced the closing of a $5 ... commercialization of several approved Lazarus Effect devices, as well ... Cover™ in the United States . ... value of our novel, platform technology as well as ...
Breaking Medicine Technology:Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 2Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 3Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 4Formulary Decision Makers Say Pharma-Provided Patient Support Solutions Influence Formulary Placement 2Formulary Decision Makers Say Pharma-Provided Patient Support Solutions Influence Formulary Placement 3Lazarus Effect Closes $5 Million Financing 2
... FRISCO, Texas, March 15, 2012  OxySure® Systems, Inc. ... easy-to-use emergency oxygen solutions with its "oxygen from ... into a Supplier Agreement ("Agreement") with W.W. Grainger, ... (Logo:  http://photos.prnewswire.com/prnh/20120315/DA71084LOGO ) In ...
... According to a national survey of independent pharmacists, ... drugstores and consumers who changed pharmacies. Independent pharmacists say ... ease, and still have many choices despite the absence ... This survey reveals significant upsides to preferred pharmacy ...
Cached Medicine Technology:OxySure Systems Announces Supplier Agreement With Grainger 2OxySure Systems Announces Supplier Agreement With Grainger 3New Survey: Walgreens' Customers Flock to Independent Pharmacies 2
... It's easy on delicate urethral ... and hydrophilic coating provide nearly ... gel. It's easy to maintain ... catheter with its own sterile ...
The latex-free, PVC-free Antibacterial Hydro Personal catheter combines two remarkable innovations into one exclusive catheter that delivers an antibacterial agent while providing the virtually frict...
... It's easy on delicate urethral ... and hydrophilic coating provide nearly ... gel. It's easy to maintain ... catheter with its own sterile ...
The latex-free, PVC-free Antibacterial Hydro Personal catheter combines two remarkable innovations into one exclusive catheter that delivers an antibacterial agent while providing the virtually frict...
Medicine Products: