Navigation Links
Neuroscientists reveal new links that regulate brain electrical activity
Date:2/16/2010

Calgary, AB Investigators in the Hotchkiss Brain Institute, Faculty of Medicine, have made a major breakthrough in our understanding of nerve impulse generation within the brain. Brain cells communicate with each other by firing electrical impulses, which in turn rely upon special ion channels that are positioned at strategic locations in their membranes. This exciting, new foundational research was published this week in the prominent journal Nature Neuroscience.

Principal Investigators, Ray W. Turner, Ph.D. and Gerald Zamponi, Ph.D. study the inhibitory and excitatory actions of ion channels in neurons of the cerebellum. Partnerships between the two laboratories, enabled Turner to 'follow his hunch' to prove that specific members of two different families of channels, previously thought to function independently, in fact function in tandem.

"A-type" potassium channels exhibit unique properties to control the timing of neuronal output. Turner's team found that these channels physically link with a class of "T-type" calcium channels that enhances their ability to control nerve impulse timing. Interestingly, T-type calcium channels also exhibit unique properties compared to other members of their family - which in retrospect forms a perfect match between the members of this new signaling complex.

"The first results that revealed this link were amazing," says Turner about this discovery. "These new developments redefine how we should look at the control of neuronal activity. They not only indicate how the timing of impulses from the cerebellum are controlled, but also predict how electrical activity in other parts of the brain is generated."

In addition to providing scientists fairly accurate ideas as to electrical regulation throughout the brain, this research may also advance pharmacological therapies for a number of neurological disorders such as epilepsy, and movement disorders such as tremor or ataxia.

Dustin Anderson, Turner's Ph.D. student and first author on the paper explains the relevance of this work in another way. "When you have a machine as complex as the human body, understanding the components, or in this case the behaviour and reactions of cellular activity, provides health researchers and physicians with answers as to how the body works and what happens when things go wrong."


'/>"/>

Contact: Lisa Fleece
hbi@ucalgary.ca
403-220-3558
University of Calgary
Source:Eurekalert

Related medicine news :

1. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
2. Jefferson neuroscientists find early lead exposure impedes recovery from brain injury
3. QBI neuroscientists make Alzheimers disease advance
4. Neuroscientists show insulin receptor signaling regulates structure of brain circuits
5. CSHL neuroscientists glimpse how the brain decides what to believe
6. CSHL neuroscientists propose project to comprehensively map mammalian brain circuits
7. Neuroscientists demonstrate link between brainwave acticity and visual perception
8. University of Louisville neuroscientists hope to get people walking again
9. NeuroFocus Adds Two More of the Worlds Leading Neuroscientists to its Advisory Board
10. USC neuroscientists awarded $9 million to map gene expression during human brain development
11. Neuroscientists at Case Western Reserve University store information in isolated brain tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... May 03, 2016 , ... ... selected by Tidelands Health, a three hospital system in South Carolina, to provide ... the lookout for technology that enhances communication, drives workflow efficiencies and improves provider ...
(Date:5/3/2016)... ... ... injury law firm Monge & Associates is honoring Moms in the time leading ... their Mother or any other mother figure. , According to law firm founder, Scott Monge, ... to say, “we are choosing to do this by giving free roses to those who ...
(Date:5/3/2016)... ... May 03, 2016 , ... Ogawa World USA introduced ... user friendly Samsung tablet and exclusive Smart Application. The Smart 3D combines the best ... massage with a customized user profile and specialized massage program, each user has a ...
(Date:5/3/2016)... Toronto, ON (PRWEB) , ... May 03, 2016 ... ... been recognized as one of Canada’s top Information and Communication Technology (ICT) companies ... top Canadian and Multinational ICT companies operating in Canada, as ranked by revenue. ...
(Date:5/3/2016)... ... May 03, 2016 , ... Huntington Beach orthopedic doctor , Dr. Rick ... can be used to diagnose and treat joint problems. During this procedure, Dr. Pospisil ... a special lighting system and lens that illuminate and magnify the various structures in ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... 3, 2016   BIOTRONIK , a leader ... Food and Drug Administration (FDA) approval of Iperia ... heart failure patients with access to diagnostic magnetic ... remote monitoring with daily automatic transmission and closed ... in response to physiological demands. ...
(Date:5/3/2016)... OSWEGO, Ore. , May 3, 2016   ... the importance of extending care beyond the implant at ... Sessions, May 4-7 in San Francisco ... with continually delivering the highest quality of patient care ... patients are cared for each and every tomorrow," said ...
(Date:5/3/2016)... 3, 2016 Pharmaceutical giant Johnson ... to a woman who says its talc-based powder products ... Gloria Ristesund $5 million in compensatory damages and ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , This is ... company. In February, the same court awarded $72 million ...
Breaking Medicine Technology: