Navigation Links
Neuroscientists reveal new links that regulate brain electrical activity
Date:2/16/2010

Calgary, AB Investigators in the Hotchkiss Brain Institute, Faculty of Medicine, have made a major breakthrough in our understanding of nerve impulse generation within the brain. Brain cells communicate with each other by firing electrical impulses, which in turn rely upon special ion channels that are positioned at strategic locations in their membranes. This exciting, new foundational research was published this week in the prominent journal Nature Neuroscience.

Principal Investigators, Ray W. Turner, Ph.D. and Gerald Zamponi, Ph.D. study the inhibitory and excitatory actions of ion channels in neurons of the cerebellum. Partnerships between the two laboratories, enabled Turner to 'follow his hunch' to prove that specific members of two different families of channels, previously thought to function independently, in fact function in tandem.

"A-type" potassium channels exhibit unique properties to control the timing of neuronal output. Turner's team found that these channels physically link with a class of "T-type" calcium channels that enhances their ability to control nerve impulse timing. Interestingly, T-type calcium channels also exhibit unique properties compared to other members of their family - which in retrospect forms a perfect match between the members of this new signaling complex.

"The first results that revealed this link were amazing," says Turner about this discovery. "These new developments redefine how we should look at the control of neuronal activity. They not only indicate how the timing of impulses from the cerebellum are controlled, but also predict how electrical activity in other parts of the brain is generated."

In addition to providing scientists fairly accurate ideas as to electrical regulation throughout the brain, this research may also advance pharmacological therapies for a number of neurological disorders such as epilepsy, and movement disorders such as tremor or ataxia.

Dustin Anderson, Turner's Ph.D. student and first author on the paper explains the relevance of this work in another way. "When you have a machine as complex as the human body, understanding the components, or in this case the behaviour and reactions of cellular activity, provides health researchers and physicians with answers as to how the body works and what happens when things go wrong."


'/>"/>

Contact: Lisa Fleece
hbi@ucalgary.ca
403-220-3558
University of Calgary
Source:Eurekalert

Related medicine news :

1. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
2. Jefferson neuroscientists find early lead exposure impedes recovery from brain injury
3. QBI neuroscientists make Alzheimers disease advance
4. Neuroscientists show insulin receptor signaling regulates structure of brain circuits
5. CSHL neuroscientists glimpse how the brain decides what to believe
6. CSHL neuroscientists propose project to comprehensively map mammalian brain circuits
7. Neuroscientists demonstrate link between brainwave acticity and visual perception
8. University of Louisville neuroscientists hope to get people walking again
9. NeuroFocus Adds Two More of the Worlds Leading Neuroscientists to its Advisory Board
10. USC neuroscientists awarded $9 million to map gene expression during human brain development
11. Neuroscientists at Case Western Reserve University store information in isolated brain tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... 21 Middle East and ... has selected 21 leaders from government, business and civil society in 11 countries across ... U.S. this fall, engaging in a transformative exchange of knowledge and ideas with the ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ross Insurance ... With the Federal Emergency Management Agency’s (FEMA) recent update of flood zones, more ... 2012, the Biggert-Waters Act was enacted to reflect the actual risk in flood ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Katyl Agency, ... to families and business owners in and around Lackawanna County, is joining Meals ... in the area. , Meals on Wheels of NEPA provides hand-delivered and nutritious ...
(Date:6/23/2017)... ... June 23, 2017 , ... Radabaugh & Associates, a locally ... business owners in North Central West Virginia, is embarking on a cooperative charity ... residents in the region. , The Stepping Stones organization offers a series of ...
(Date:6/22/2017)... ... June 22, 2017 , ... Plastic Surgery Associates is proud to report ... 2017. Each year, research and information firm, Castle Connolly, releases their list of the ... this marks the 3rd time that Dr. Canales has been recognized by ...
Breaking Medicine News(10 mins):
(Date:5/29/2017)... 2017  Cellect Biotechnology Ltd. (NASDAQ: APOP ... the functional selection of stem cells, today provided a ... quarter ended March 31 st , 2017. ... the first quarter of 2017," said Dr. Shai Yarkoni, ... the treatment of the first blood cancer patient in ...
(Date:5/24/2017)... 2017  ivWatch LLC today announced the launch ... to enable seamless integration of ivWatch,s groundbreaking IV ... pumps and other devices. By integrating ivWatch technology ... help health care customers deliver a higher level ... IV therapy. "The ivWatch OEM Board ...
(Date:5/22/2017)... 22, 2017  As the specialty pharmacy industry ... to make the revolutionary shift from volume-based to ... ensuring positive patient outcomes and shaping the future ... focus away from clinical trials and toward data ... specialty drug therapy utilization in precise patient populations. ...
Breaking Medicine Technology: