Navigation Links
Neuroscientists find overlooked brain area is an important locus of depression
Date:2/23/2011

Cold Spring Harbor, NY -- A team of neuroscientists at Cold Spring Harbor Laboratory (CSHL), Brookhaven National Laboratory (BNL) and UC San Diego (UCSD) has collected evidence suggesting that a previously overlooked portion of the brain could be a prime locus of human depression.

In two rat models of human depression, the scientists have demonstrated that neurons in a tiny area in the central brain called the lateral habenula (LHb) are hyperactive.

Specifically, as the team reports today online ahead of print in the journal Nature, excitatory synaptic inputs onto neurons in the LHb are enhanced in "depressed" animals, a finding they regard significant because this excitation in turn causes the inhibition of "downstream targets" -- including neurons in a part of the brain called the ventral tegmental area (VTA), important in the brain's reward system and heavily populated by dopamine neurons.

Furthermore, the team, which includes Professor Fritz Henn of CSHL and BNL and Assistant Professor Bo Li of CSHL, as well as Professor Roberto Malinow of UCSD, was able to use an analog of deep brain stimulation (DBS), a novel form of electrical stimulation involving the implantation of electrodes into a specific brain area, to reverse depression-like symptoms in the rats.

DBS is an important new experimental modality of treatment for refractory depression in people, as well as a potentially important approach to treat other neurophysiological disorders, most notably Parkinson's disease. The team's results point to the LHb as a potential therapeutic target for DBS. A series of ongoing experiments in depression at other laboratories, which have shown promise in a small number of human patients, have used DBS to target an area of the cingulate cortex called Brodman's Area 25. Henn and colleagues in Germany last year reported success in treating one case of intractable human depression with DBS, targeting the LHb.

The animal
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Neuroscientists reveal new links that regulate brain electrical activity
2. Ion channel responsible for pain identified by UB neuroscientists
3. MIT neuroscientists explain Proustian effect of small details attached to big memories
4. Chlamydia Often Overlooked in Young Men
5. Depression overlooked in patients with hepatitis C; compromising HCV therapy
6. Some kids with spinal cord injury may be overlooked for walking rehabilitation
7. Damage of False-Positive Mammograms Overlooked: Study
8. Gadgets not related to teenagers brain pain
9. Dementia Rates Escalate as Brain Capacity Diminishes with Age
10. Researchers discover new way to kill pediatric brain tumors
11. Scientists Pinpoint Area of Brain That Fears Losing Money
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... 2014 Mirena IUD lawsuits ( http://www.themirenalawsuitcenter.com/ ... migration of the birth control device continue to mount ... According to court documents dated September 18th, an Iowa ... the IUD outside of the uterus caused the device ... is now pending in the U.S. District Court, Northern ...
(Date:9/23/2014)... 2014 The inaugural single day event ... Hotel New Otani Tokyo Gardens in Tokyo. Clinical data scientists ... and validation. , The second single day event in ... offices in Shanghai. The clinical data scientists attending this event ... figures and listings, which display data collected in clinical studies ...
(Date:9/23/2014)... Oakland, CA (PRWEB) September 23, 2014 ... Cannabis Industry Today . In its first post, the ... quickly growing and changing cannabis industry. , The cannabis ... , Colorado alone is expecting an 18-month boost of ... medicinal and adult use pot sales. And, the new ...
(Date:9/23/2014)... 23, 2014 Florida Hospital Zephyrhills ... renovated Women’s Health Center on Wednesday, September 24. ... the specially designed center offers a new level ... County. The Women’s Health Center offers comprehensive women’s ... labor and delivery through The Baby Place®, and ...
(Date:9/23/2014)... A new analysis of published studies found that ... cancer versus benign disease in regions where infections ... of lung lesions suspicious for cancer could lead ... additional potential complications and mortality. , Histoplasmosis ... that are often concentrated in bird droppings and ...
Breaking Medicine News(10 mins):Health News:Mirena IUD Lawsuit News: New Complaint Filed On Behalf of Iowa Woman Claims Mirena Migrated to Her Rectum, Bernstein Liebhard LLP Reports 2Health News:Mirena IUD Lawsuit News: New Complaint Filed On Behalf of Iowa Woman Claims Mirena Migrated to Her Rectum, Bernstein Liebhard LLP Reports 3Health News:Mirena IUD Lawsuit News: New Complaint Filed On Behalf of Iowa Woman Claims Mirena Migrated to Her Rectum, Bernstein Liebhard LLP Reports 4Health News:PhUSE Further Expands its Global Community Into the Asian Region 2Health News:Oaksterdam University Addresses "Why Quality Training Matters in a Growing Marijuana Industry" in First Blog Post 2Health News:Oaksterdam University Addresses "Why Quality Training Matters in a Growing Marijuana Industry" in First Blog Post 3Health News:Florida Hospital Zephyrhills Celebrates Grand Opening of Women’s Health Center 2Health News:Florida Hospital Zephyrhills Celebrates Grand Opening of Women’s Health Center 3Health News:Study questions accuracy of lung cancer screens in some geographic regions 2
... community-based oncology practices , , HOUSTON, June 10 ... nation,s foremost cancer treatment and research network and working with ... announces the launch of iKnowMed(TM) to ... health record (EHR) system designed by oncologists for ...
... ... $500 savings bond giveaway for expectant parents. M.A.Z.E. is dedicated to helping parents save ... ... -- Expectant parents can start investing for their child,s education with M.A.Z.E. Cord Blood Laboratories. ...
... 10 The Anthropedia Foundation, a non-profit organization with headquarters ... Switzerland, where it will host its first annual gala. The ... at Le Vieux Manoir, a five-star Relais & Chateaux Hotel ... artists, executives, doctors, scientists, and distinguished guests will enjoy a ...
... legally sell alcohol to teenagers after their sixteenth birthdays ... early age, but U.S. parents who follow this relaxed ... alcohol, should be careful -- it may increase the ... conducted by Caitlin Abar, graduate student, human development and ...
... 10 PIBH recognized 23 outstanding Pennsylvania workers and ... with disabilities, particularly in the workplace. , , ... at the Hilton Hotel in Harrisburg last night, celebrated ... day, however, PIBH honors the spirit and skills of ...
... , Havel,s partners with Canadian Hospital Specialties, to ... , , CINCINNATI, June 10 ... devices, has partnered with CHS, Canadian Hospital Specialties, ... EchoStim(R) and EchoBlock(R) Ultrasound Needles throughout Canada. , ...
Cached Medicine News:Health News:US Oncology Launches Oncology-Specific EHR to the Open Market 2Health News:US Oncology Launches Oncology-Specific EHR to the Open Market 3Health News:US Oncology Launches Oncology-Specific EHR to the Open Market 4Health News:M.A.Z.E. Cord Blood Laboratories Offers Expectant Parents The Chance To Win A $500 Savings Bond 2Health News:Anthropedia Foundation Charity Gala, Murten, Switzerland, in the Presence of HSH Prince Albert II of Monaco 2Health News:Zero tolerance alcohol policy good choice for parents 2Health News:PIBH with NFL Star Doug Flutie Recognizes 23 PA Workers with Disabilities, 21 Organizations Supporting Those with Disabilities 2Health News:PIBH with NFL Star Doug Flutie Recognizes 23 PA Workers with Disabilities, 21 Organizations Supporting Those with Disabilities 3Health News:PIBH with NFL Star Doug Flutie Recognizes 23 PA Workers with Disabilities, 21 Organizations Supporting Those with Disabilities 4Health News:PIBH with NFL Star Doug Flutie Recognizes 23 PA Workers with Disabilities, 21 Organizations Supporting Those with Disabilities 5Health News:PIBH with NFL Star Doug Flutie Recognizes 23 PA Workers with Disabilities, 21 Organizations Supporting Those with Disabilities 6Health News:Havel's Incorporated Expands Successful EchoStim(R) Ultrasound Needles into Canada 2
(Date:9/23/2014)... 23, 2014 In industries such ... sectors, the machines are more and more connected and ... amounts of data are being harvested by numerous sensors ... number of connected machines is estimated at several dozen ... raises the fundamental question as to how big data ...
(Date:9/23/2014)... DUBLIN , Sept. 23, 2014 ... the "Company"), a biotechnology company pioneering the manufacturing ... in emerging nations, today announced that the Depository ... for DTC,s Deposit and Withdrawal at Custodian ("DWAC") ... ("FAST") transfer agent as the distribution point.  The ...
(Date:9/23/2014)... 2014 This test can detect HIV infection if ... defined by activities that can transfer body fluids from one ... any shared needles. , An in-vitro diagnostic home-use ... HIV test works by looking for your body,s response to ... minutes, enabling patients to learn their status in a single ...
Breaking Medicine Technology:TNI BioTech, Inc. Announces Its Stock is Now DTC DWAC/FAST Eligible 2TNI BioTech, Inc. Announces Its Stock is Now DTC DWAC/FAST Eligible 3TNI BioTech, Inc. Announces Its Stock is Now DTC DWAC/FAST Eligible 4WholeHealth Products announces the release of the FDA Cleared "HIV 1&2" Rapid Diagnostic Test for Professional and Retail 2
... - Ambrilia,Biopharma Inc. (TSX:AMB), a biopharmaceutical company developing,novel ... and,cancer, held its Annual General and Special Meeting ... novel series of HIV,integrase inhibitors and recent developments ... Chairman of the Board, Mr. Frederic,Porte, and a ...
... 2007 /PRNewswire/ -- Results of the,Option (TOcilizumab ... first multinational Phase III study outside,of Japan, ... 4mg/kg,or 8mg/kg) plus methotrexate achieved a significant ... symptoms of moderate to,severe rheumatoid arthritis (RA) ...
Cached Medicine Technology:Ambrilia Highlights Encouraging Data for its HIV Integrase,Inhibitor Program and Recent Developments at Annual Meeting 2Ambrilia Highlights Encouraging Data for its HIV Integrase,Inhibitor Program and Recent Developments at Annual Meeting 3Ambrilia Highlights Encouraging Data for its HIV Integrase,Inhibitor Program and Recent Developments at Annual Meeting 4Actemra (tocilizumab) Significantly Improves Symptoms of Rheumatoid,Arthritis Compared to a Current Standard of Care 2Actemra (tocilizumab) Significantly Improves Symptoms of Rheumatoid,Arthritis Compared to a Current Standard of Care 3Actemra (tocilizumab) Significantly Improves Symptoms of Rheumatoid,Arthritis Compared to a Current Standard of Care 4Actemra (tocilizumab) Significantly Improves Symptoms of Rheumatoid,Arthritis Compared to a Current Standard of Care 5
... groups of flexible lighting products. The first ... three different sizes 5", 10", and 15" ... the light). These lights are for use ... ,The second group of flexible lights ...
These units, though small, still offer sufficient output to ensure current is fully adjustable from 0 to 70 mA. Instruction manual, ball electrodes, battery and leads with alligator clips are include...
... two groups of flexible lighting products. The ... in three different sizes 5", 10", and ... of the light). These lights are for ... needed., ,The second group of flexible ...
Designed to be used for neuromuscular blockage monitoring. Provides for easy placement over the ulnar nerve on a patient's wrist. Dual element permits non-invasive monitoring using a single electrode...
Medicine Products: