Navigation Links
Neuroscientists find overlooked brain area is an important locus of depression
Date:2/23/2011

Cold Spring Harbor, NY -- A team of neuroscientists at Cold Spring Harbor Laboratory (CSHL), Brookhaven National Laboratory (BNL) and UC San Diego (UCSD) has collected evidence suggesting that a previously overlooked portion of the brain could be a prime locus of human depression.

In two rat models of human depression, the scientists have demonstrated that neurons in a tiny area in the central brain called the lateral habenula (LHb) are hyperactive.

Specifically, as the team reports today online ahead of print in the journal Nature, excitatory synaptic inputs onto neurons in the LHb are enhanced in "depressed" animals, a finding they regard significant because this excitation in turn causes the inhibition of "downstream targets" -- including neurons in a part of the brain called the ventral tegmental area (VTA), important in the brain's reward system and heavily populated by dopamine neurons.

Furthermore, the team, which includes Professor Fritz Henn of CSHL and BNL and Assistant Professor Bo Li of CSHL, as well as Professor Roberto Malinow of UCSD, was able to use an analog of deep brain stimulation (DBS), a novel form of electrical stimulation involving the implantation of electrodes into a specific brain area, to reverse depression-like symptoms in the rats.

DBS is an important new experimental modality of treatment for refractory depression in people, as well as a potentially important approach to treat other neurophysiological disorders, most notably Parkinson's disease. The team's results point to the LHb as a potential therapeutic target for DBS. A series of ongoing experiments in depression at other laboratories, which have shown promise in a small number of human patients, have used DBS to target an area of the cingulate cortex called Brodman's Area 25. Henn and colleagues in Germany last year reported success in treating one case of intractable human depression with DBS, targeting the LHb.

The animal
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Neuroscientists reveal new links that regulate brain electrical activity
2. Ion channel responsible for pain identified by UB neuroscientists
3. MIT neuroscientists explain Proustian effect of small details attached to big memories
4. Chlamydia Often Overlooked in Young Men
5. Depression overlooked in patients with hepatitis C; compromising HCV therapy
6. Some kids with spinal cord injury may be overlooked for walking rehabilitation
7. Damage of False-Positive Mammograms Overlooked: Study
8. Gadgets not related to teenagers brain pain
9. Dementia Rates Escalate as Brain Capacity Diminishes with Age
10. Researchers discover new way to kill pediatric brain tumors
11. Scientists Pinpoint Area of Brain That Fears Losing Money
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... affects more than one out of three survivors ... released in The Lancet Respiratory Medicine , ... physically rather than mentally. , It is one ... health and functional outcomes of critical care survivors, ... professor of Medicine, and it highlights a significant ...
(Date:4/24/2014)... in the world to discover a gene mutation in ... Ameloblastoma is an odontogenic tumour with a high tendency ... in the posterior of the lower jaw. Ameoloblastomas are ... the jaws as well as loss of several teeth. ... surgery and the recurrence of ameloblastoma, but finding such ...
(Date:4/24/2014)... An Oregon State University researcher has found a relationship ... symptoms of autism spectrum disorder in very young children. ... first to show a direct relationship between motor skills ... gross motor skills should be included in treatment plans ... assistant professor in OSU,s College of Public Health and ...
(Date:4/24/2014)... virus caused the first flu pandemic in the 21st ... killed more than 50 people in the country. Since ... epidemics (winter/spring seasons). , Infections with influenza pH1N1 ... Health Organization has recommended Tamiflu for treatment of patients ... drug is that it targets viral proteins which mutate ...
(Date:4/23/2014)... Massachusetts General Hospital (MGH) investigators may lead to greater ... serious medical problem use of fecal material from ... Clostridium difficile ( C. difficile ) bacteria. ... journal Clinical Infectious Diseases , the researchers report ... unrelated to patients was as successful in curing recurrent ...
Breaking Medicine News(10 mins):Health News:Vanderbilt study finds physical signs of depression common among ICU survivors 2Health News:Vanderbilt study finds physical signs of depression common among ICU survivors 3Health News:Motor skill deficiencies linked to autism severity in new research 2Health News:Use of frozen material for fecal transplant successfully treats C. difficile infection 2Health News:Use of frozen material for fecal transplant successfully treats C. difficile infection 3
... to test the caffeine content of beverages such as tea, ... clear your suspicion about the decaf label that claims reduced ... researchers at Washington University School of Medicine, is based on ... been published in the journal, Analytical Chemistry, a publication of ...
... among people. The main reason is the belief that a ... But according to a popular magazine, the choice, it was ... shot of wheatgrass is$3. Choice health policy officer Viola Korczak ... ,What the researchers feel is that they the ...
... the government on HIV/AIDS, tuberculosis and malaria. He said ... passed,// declaring that at least 80 % of the ... HIV/AIDS treatment such as antiretroviral (ARV) drugs, care and ... targets but were doubtful whether these will be met. ...
... Office workers are at an increased risk of being affected ... hours on their computer.// DVT is a condition that gives ... the heat or the lung with often fatal consequences. ,This ... e-thrombosis. The condition came to light after it emerged that ...
... has pointed out the alarming incidence of metabolic syndrome among ... million people, approximating// to one-fifth of the total population face ... ,In view of this health threat, the government health officials ... and do more exercise, if these effects were to be ...
... about one to two a day can help prevent osteoporosis. ... and St Thomas’ Hospitals in London have found that the ... bone loss. ,It has been estimated that about ... bones to weaken and fracture easily. The NHS spends around ...
Cached Medicine News:Health News:Caffeine Content In Beverages To Be Identified By Home Test Kit 2Health News:Beer to Ward off Osteoporosis 2
(Date:1/15/2014)... , Jan. 15, 2014 Most osteoporosis patients want ... a recent online survey* sponsored by Mission Pharmacal Company. ... National Osteoporosis Foundation online support community, revealed that 74 ... that comes in a form other than a pill ...
(Date:1/15/2014)... , Jan. 15, 2014 AARP Foundation today announced it ... adults suffering from the severe cold weather that has gripped ... to helping those in need; so to support these emergency ... up to $250,000, which could mean up to $500,000 in ...
(Date:1/15/2014)... Calif. , Jan. 15, 2014 Massachusetts ... (NASDAQ: AMGN ) announced today that ... discover and validate new therapeutic targets and develop ... chronic disorder that affects millions worldwide. The MGH-Broad-Amgen ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4
... 23 PDI, Inc. (Nasdaq: PDII ), a leading provider ... been awarded a significant contract sales engagement with a Top 5 ... in revenue for PDI during the first quarter of 2010 and ... people of PDI have been working very hard to provide unequaled ...
... 22 The last large H1N1 influenza vaccination clinic for the ... Department. It is free of charge and will take place next ... 10 a.m. to 3 p.m. Everyone over 6 months of age ... is also offering immunizations at its three health centers in Macomb ...
Cached Medicine Technology:PDI Announces New Pharmaceutical Services Business Win With a Top 5 Pharmaceutical Company 2Macomb County Announces Final 2009 H1N1 Clinic 2
FM Style Neonatal Flowmeters (Brass Body)...
... features for the professional ophthalmic photographer. Integrated ... and background illumination, all controlled through a ... joystick, as well as adaptors allowing for ... range professional level digital and 35 mm ...
... The system that makes it all ... Biology Workstation is an automated multi-purpose ... sequences, such as in the analysis ... Short Tandem Repeats (STRs) using the ...
Assess serum Gc-globulin levels in patients with multiple trauma, fulminant liver failure, acetaminophen overdose, and sepsis....
Medicine Products: