Navigation Links
Neuronal survival and axonal regrowth obtained in vitro
Date:7/24/2009

While repair of the central nervous system has long been considered impossible, French researchers from Inserm, the CNRS and the UPMC have just developed a strategy that could promote neuronal regeneration after injury. The in vitro studies have just been published in the journal PLoS ONE.

Repair of the central nervous system and restoration of voluntary motor activity through axonal re-growth has long been considered impossible in mammals. Over the last decade, numerous attempts proved disappointing overall. The Inserm team led by Alain Privat has recently shown that an essential component interfering with regeneration was due to the activity of astrocytes, feeder cells that surround neurons.

Normally, the primary role of astrocytes is to supply the nutrients necessary for neuronal function. In the event of spinal injury or lesion, astrocytes synthesize two particular proteins (glial fibrillary acidic protein (GFAP) and vimentin), which isolate the damaged neuron to prevent interference with the operation of the central nervous system.

While the protection is initially useful, in the long run it induces formation of impermeable cicatricial tissue around the neuron, thus constituting impenetrable scarring hostile to axonal regeneration and hence to propagation of nervous impulses. In the event of severe injury, the scarring engenders motor paralysis.

On the basis of the initial findings, the researchers pursued a strategy aimed at developing a therapeutic instrument to block formation of cicatricial tissue. In order to do so, they used gene therapy based on use of interfering RNA. The short RNA sequences, which were made to measure, were inserted into the cytoplasm of cultured astrocytes using a viral therapeutic vector. Once in the cell, the RNA activates mechanisms which block the synthesis of the two proteins secreted by astrocytes and responsible for cicatrix formation. Using that technique, the researchers succeeded
'/>"/>

Contact: Alain Privat
privat@univ-montp2.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. St. Jude Scientists Discover a New Mechanism Controlling Neuronal Migration
2. Novel Photoconductive Cellular Depolarization Technology Reveals Insight Into Neuronal Growth, Guidance, and Regeneration
3. Neuronal regulators offer potential targets for cancer
4. Abbott Researchers Target Neuronal Nicotinic Receptors for Treatment of Pain and Cognition
5. Low level of neuronal receptor linked to mild cognitive impairment and Alzheimers disease
6. Nexavar in Combination with Chemotherapy Shown to Extend Progression-Free Survival in Patients with Advanced Breast Cancer
7. Genetic Variation Associated With Survival Advantage in African Americans With HIV
8. Study finds survival rates from gastrointestinal tumors improving among African-Americans
9. First Annual Congressional Womens Softball Game to Benefit the Young Survival Coalition
10. CPR Survival Rates for Older People Unchanged
11. LSUHSC research identifies enzyme that makes survival molecule for key vision cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... NY (PRWEB) April 21, 2015 ... a 2015 Professional Woman of the Year. Ms. Webb ... healthcare. As the largest, most-recognized networking organization of professional ... profession, the National Association of Professional Women is a ... over 200 local chapters. , “We are like an ...
(Date:4/20/2015)... April 20, 2015 The NFL draft season ... of players to add to their rosters, both for their ... In this episode of SCI TV , Vinnie ... acquisition of Greg Hardy given increased attention on off-field conduct ... year after the Ray Rice scandal brought media scrutiny, once ...
(Date:4/20/2015)... At the famous Avalon Hollywood on April 8th, ... Lounge, with Choices Recovery as the premier sponsor. Organizer ... placement in TV and film, gathered some of the ... goods and services for this daylong event. , ... Celebrity Interview Lounge, speaking with many of the notable ...
(Date:4/20/2015)... Utah (PRWEB) April 20, 2015 Goodreads ... Employer-Provided Health Insurance: Why It’s Good for You and ... , Paul Zane Pilzer and Rick Lindquist have ... Health Insurance: Why It’s Good for You and Your ... nation’s employer health insurance woes - employer-funded individual health ...
(Date:4/20/2015)... Hilo, Hawaii (PRWEB) April 20, 2015 ... , so hurry and secure your space at the start ... 12, 2015, the Olympic-distance race is limited to 500 participants ... Kenoi has already secured his spot). , Now thru April ... $75 for relay team members; after May 1st, the fee ...
Breaking Medicine News(10 mins):Health News:National Association of Professional Women Announces Suzanne Webb, Chief Executive Officer at Exclusive Surgeries Network, LLC, a 2015 Professional Woman of the Year 2Health News:Character Concerns in the NFL with Vinnie Iyer on SCI TV 2Health News:Choices Recovery South Bend Talks About Healthy Decisions with TV's Adrienne Janic 2Health News:Zane Benefits Announces Complimentary Book Giveaway On GoodReads: The End of Employer-Provided Health Insurance: Why It's Good for You and Your Company 2Health News:Zane Benefits Announces Complimentary Book Giveaway On GoodReads: The End of Employer-Provided Health Insurance: Why It's Good for You and Your Company 3Health News:Hilo Triathlon Kicks Up Its Heels A Second Time; Early Bird Registration Available Online Now. 2Health News:Hilo Triathlon Kicks Up Its Heels A Second Time; Early Bird Registration Available Online Now. 3
... PALM BEACH, Fla., Oct. 12 The inaugural Cosmetic ... was called an unqualified success by those that attended. ... the meeting was a great learning opportunity and it ... LLC and its corporate partners. Attendees came from ...
... Noninvasive Medical Technologies, Inc. (NMT), an award-winning company ... pleased to commit its support to the Tim Davis Special ... man teams are currently relay marching over 824 miles across ... plaque with Staff Sgt. Tim Davis, name engraved. U.S. ...
... stem cells are being used to help develop a heart ... researchers have achieved a first step toward growing a living ... mouse embryonic stem cells, Duke University bioengineers performed a series ... develop into heart muscle. , The researchers used a special ...
... ... Inc., innovative provider of one-stop, flat-fee healthcare information technology and support, ... records (EMR) clients through the hiring of new Chief Healthcare Officer ... hosting and billing services to practices and medical groups of all ...
... CHICAGO, Oct. 12 On Tuesday, October 13, in response ... 33 state think tanks will announce their "patient-centered" plan for ... a national study by public policy specialist Art Laffer, will ... on a conference call open to the press (dial-in information ...
... ... receives Active Substance Master File for Cell Sense in vivo imaging agent , ... Pittsburgh, PA (Vocus) October 12, 2009 -- ... for its lead in vivo imaging reagent, Cell Sense CS-1000 (Cell Sense). , ,Celsense filed a ...
Cached Medicine News:Health News:Noninvasive Medical Technologies Supports 824-Mile Tim Davis Special Tactics Memorial March 2Health News:Noninvasive Medical Technologies Supports 824-Mile Tim Davis Special Tactics Memorial March 3Health News:Lab Study Makes Strides in Mending Hearts 2Health News:ITelagen Taps Joel Taylor as Chief Healthcare Officer New Executive to Spearhead EMR Implementations 2Health News:ITelagen Taps Joel Taylor as Chief Healthcare Officer New Executive to Spearhead EMR Implementations 3Health News:The Obamacare Alternative: 33 State Think Tanks Announce Patient-Centered Health Care Reforms 2Health News:Celsense, Inc Files FDA & EMEA Regulatory Submissions 2Health News:Celsense, Inc Files FDA & EMEA Regulatory Submissions 3
(Date:4/20/2015)... STAMFORD, Conn. , April 20, 2015 /PRNewswire/ ... announced that Alan Butcher has joined ... & Business Development. Alan will have responsibility for ... commercial, near-commercial, and development-stage products that would benefit ... bringing aboard a proven leader," said Purdue President ...
(Date:4/20/2015)... April 20, 2015  U.S. pharmacy cost increases for active ... into the low double-digits by 2016, according to an analysis ... health solutions business of Aon plc (NYSE: ... projected to be 9.5 percent in 2015 and will continue ... predicts a similar rate of increase in 2017, with ...
(Date:4/20/2015)... 2015 Cardinal Innovations Healthcare Solutions ... high-tech, high-touch service delivery, is featuring its highly ... the National Council for Behavioral Health,s annual National ... 20–22, 2015, at the Gaylord Palms Resort and ... , attracts participants from mental health and addiction ...
Breaking Medicine Technology:Purdue Pharma Names J. Alan Butcher Senior Vice President of Licensing & Business Development 2Aon Analysis Shows Double-Digit Increases in U.S. Pharmacy Costs by 2016 2Aon Analysis Shows Double-Digit Increases in U.S. Pharmacy Costs by 2016 3Aon Analysis Shows Double-Digit Increases in U.S. Pharmacy Costs by 2016 4Cardinal Innovations Highlights its Managed Care Model During National Council for Behavioral Health's Annual Conference 2Cardinal Innovations Highlights its Managed Care Model During National Council for Behavioral Health's Annual Conference 3
... SureFlex™ line of reusable and autoclavable Lithotripsy ... This revolutionary and patented termination method accepts ... In the unlikely event you do manage ... face absolutely prevents damage to your laser ...
ELVeS™ (Endo Laser Vein System) from biolitec is a versatile, easy to use & complete system that allows you to treat all conditions resulting from venous incompetence. (ELVeS has FDA clearance ...
Up-tapered output compresses NA to give low NA fiber performance on high NA fiber stock....
One piece, 100% fused silica construction offers low scatter and high efficiency...
Medicine Products: