Navigation Links
Neuronal regulators offer potential targets for cancer
Date:3/19/2008

Boston, Mass. (March 19, 2008) -- Being too brainy can be a bad thing in a junior high cafeteria, where the social hierarchy favors other traits. "Braininess" also causes problems for cells. When a breast cell begins making the proteins normally produced in neurons, for example, it can acquire cancerous properties.

Now, researchers in Stephen Elledge's laboratory at Harvard Medical School (HMS) have identified some of the switches that control this transformation, providing promising new therapeutic targets in some types of cancer. Their results appear in the March 20 issue of Nature.

"These switches play an important physiologic role in neural development and pathologic role in cancer," says first author Thomas Westbrook, who is now an assistant professor at Baylor College of Medicine. "I'm optimistic that we can use small molecules to control them."

In a previous study, Westbrook showed that a protein called REST--which keeps neural programs silent in most parts of the body--serves as a tumor suppressor.

"He's now identified a protein that promotes tumor growth by tagging REST for destruction, thereby activating neural programs," says Elledge, who holds primary appointments in the HMS Department of Genetics and at Brigham and Women's Hospital.

If the protein REST worked at a club, he would be a bouncer, preventing dozens of rowdy patrons from causing trouble. REST serves as a "master repressor," keeping numerous neural genes silent in breast cells, lung cells, etc, where they could wreak havoc. When REST disappears, these genes roar to life, pushing cells to become more like neuron precursor cells.

But cells outside the nervous system keep neural genes silent for a reason. When neural genes get switched on in breast cells anchored to surfaces, for example, they acquire the ability to live without the anchoring that is essential for normal cells to survive. That is, they can grow in suspension, which is a
'/>"/>

Contact: Alyssa Kneller
public_affairs@hms.harvard.edu
617-432-0442
Harvard Medical School
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Abbott Researchers Target Neuronal Nicotinic Receptors for Treatment of Pain and Cognition
2. Low level of neuronal receptor linked to mild cognitive impairment and Alzheimers disease
3. Deficient regulators in the immune system responsible for type 1 diabetes
4. Promising new TB drug given special status by US and European regulators
5. AARP Calls on State Regulators to Reject Proposed Settlement of TXU Buyout
6. Waters Offers U.S. Water Authorities Complimentary Drinking Water Testing for the Presence of Pharmaceuticals
7. Mirion Technologies to Showcase New Product Offerings for the Nuclear Industry During 10th Annual China International Nuclear Industry Exhibition
8. SearchMedica Offers Medical Professionals Six New Specialized Clinical Web Searches
9. Cardinal Health, GE Healthcare Broaden Relationship to Offer Greater Access to Myoview(TM) Imaging Agent
10. Peapod Offers First Ever Virtual Nutritionist
11. Agilysys Hosts IBM Specialist at Health Care Webinar Offering Data Storage Solutions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/19/2014)... 20, 2014 The leading review ... http://www.top10bestseohosting.com/go/iPage/ ) and GreenGeeks are the best Dedicated ... for those who want to buy high quality ... , The IT manager of Top10BestSEOHosting.com says, “We ... recommended suppliers for everyone. A lot of the ...
(Date:10/19/2014)... UNITED NATIONS, New York (PRWEB) October 19, 2014 ... the United Nations Population Fund, welcomes news of a ... release of the more than 200 girls who were ... Girls. "These girls have languished in captivity long enough, ... their families, schools and communities," stated Dr. Osotimehin. , ...
(Date:10/19/2014)... October 20, 2014 Having been working in ... good knowledge of customer needs. According to James, one of ... with dazzling sequins, or with high-low skirts that add beauty ... huge demand. Recently, LunaDress has unveiled its new selection of ... fact, the company’s brand new items are available in over ...
(Date:10/19/2014)... Recently, Fancyflyingfox.com, an innovative company that provides many ... latest designs of 2014 mother of the bride ... are offered with big discounts, up to 70% off. ... can enjoy this special offer. , Owing to ... become one of the leading brands in the global ...
(Date:10/19/2014)... NC (PRWEB) October 19, 2014 ... building program has just been released to the ... the online body building and fitness community. The ... attention of DietsAndFitnessGuides.com's Vin Delmonico prompting an investigative ... experience of hitting what is commonly known as ...
Breaking Medicine News(10 mins):Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2Health News:2014 Long Prom Dresses From LunaDress Now Available In Over 20 Popular Designs 2Health News:Fancyflyingfox.com Updates Its Website With New Mother Of The Bride Dresses For 2014 2Health News:Visual Impact Frequency Training Review: Rusty Moore's Latest Fitness Guide Released 2
... The spoils of war for returning veterans may include ... they witnessed. Now a University of Houston joint ... and Development service looks to address these issues through ... Graduate College of Social Work (GCSW) joins Baylor College ...
... (HealthDay News) -- Depression rates are higher in richer ... researchers who compared socioeconomic conditions with depression. About ... people,s quality of life by affecting their ability ... to suicide and causes 850,000 deaths every year. ...
... -- A person,s brain works hard to empathize or understand ... matter how different they may be, a new study indicates. ... automatically attempt to empathize -- even with those who are ... two separate regions of their brain. In a paper, ...
... FOR JULY 26, 2011] Antibiotic overuse and resistance have ... Following an outbreak of Clostridium difficile infections, which often ... Canada targeted physicians and pharmacists with an education campaign ... published in Clinical Infectious Diseases and now ...
... ,Researchers have identified ... dilated cardiomyopathy (heart muscle disease), according to results from a ... (NHLBI) of the National Institutes of Health. Using ... children who will or will not benefit from life-saving transplantation ...
... MONDAY, July 25 (HealthDay News) -- The varicella vaccine has nearly ... study shows. The vaccine, introduced in a one-dose form ... all age groups and by 97 percent in young people 20 ... Immunization and Respiratory Diseases. "This is one of our ...
Cached Medicine News:Health News:Returning vets' alcohol abuse addressed in virtual reality study 2Health News:Depression Higher in Wealthier Nations 2Health News:Human Brains Wired to Empathize, Study Finds 2Health News:Simple guidelines decreased unnecessary antibiotic use in Quebec, Canada 2Health News:Study finds important risk factors for death/transplantation in children with heart muscle disease 2Health News:Chickenpox Vaccine May Wipe Out Related Deaths: Study 2Health News:Chickenpox Vaccine May Wipe Out Related Deaths: Study 3
(Date:10/17/2014)... Calif. , Oct. 17, 2014  Amgen (NASDAQ: ... R. Sanders Williams , M.D., president of Gladstone ... Distinguished Professor.  "We are pleased to ... Board," said Robert A. Bradway , chairman and ... distinguished experience in academic medicine and his direct experience ...
(Date:10/17/2014)... 2014 According to ... Technique (Optical Coherence Tomography, Hyperspectral Imaging, Photoacoustic ... Neurology, Oncology, Cardiology) - Global Forecasts to ... Optical Imaging market over the forecast period ... $917.1 million in 2014 and is expected ...
(Date:10/17/2014)... 17, 2014 The following is being ... The Green Park Collaborative (GPC) will ... private payers, medical device and pharmaceutical companies, as ... January 12, 2015 at its first ever workshop ... loss treatments.  Participants will discuss study designs to ...
Breaking Medicine Technology:Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 3Optical Imaging Market Worth $1,669.2 Million by 2019 2Optical Imaging Market Worth $1,669.2 Million by 2019 3Optical Imaging Market Worth $1,669.2 Million by 2019 4Green Park Collaborative to Discuss Comparative Effectiveness and Value of Weight Loss Treatments 2
... Orthopedic Group, Inc. (NYSE: HGR ) today announced that ... private offering to qualified institutional buyers pursuant to Rule 144A under ... Regulation S under the Securities Act.  The notes were priced at ... expected to close on November 2, 2010. The notes ...
... Md. and INDIANAPOLIS, Oct. 20 MacroGenics, Inc. and ... today announced that the Protege Data Monitoring Committee (DMC), ... and biostatistics, has completed a planned analysis of one-year ... clinical trial of teplizumab, an investigational biologic under development ...
Cached Medicine Technology:Hanger Orthopedic Group, Inc. Announces Pricing of $200 Million of Senior Notes 2Hanger Orthopedic Group, Inc. Announces Pricing of $200 Million of Senior Notes 3MacroGenics and Lilly Announce Pivotal Clinical Trial of Teplizumab Did Not Meet Primary Efficacy Endpoint 2MacroGenics and Lilly Announce Pivotal Clinical Trial of Teplizumab Did Not Meet Primary Efficacy Endpoint 3
... The 6060 MULTI-THERAPY Infusion ... of infusion profiles that ... reliable delivery. Designed for ... the 6060 MULTI-THERAPY Pump ...
... COLLEAGUE pumps can be customized with selectable ... care sites and therapies. The COLLEAGUE ... to be used for both gravity and ... costs. From simple infusions to medication therapies ...
... Pathology and Laboratory Medicine at the Cleveland ... most comprehensive academic medical center laboratories. With ... more than 40 pathologists and PhDs, our ... results, interpretations and diagnostic consultations annually. Our ...
Focus Diagnostics Reference Laboratory is known for quality infectious disease and autoimmune testing services. We offer over 1200 tests and panels and are continually adding new tests to our menu....
Medicine Products: