Navigation Links
Neuronal migration errors: Right cells, wrong place
Date:1/4/2011

Philadelphia, PA, 4 January 2011 - Normally, cortical nerve cells or neurons reside in the brain's gray matter with only a few scattered neurons in the white matter, but some people with schizophrenia have a higher number of neurons in the white matter. Neuronal migration errors may arise in schizophrenia as a consequence of both genetic and environmental factors.

The phenomenon of aberrant cellular localization has now been studied in detail in a paper by Yang and colleagues, published in the current issue of Biological Psychiatry.

Using a specialized technique that involves staining cells, the researchers were able to determine the distribution of nerve cells in brain tissue from people who had been diagnosed with schizophrenia in comparison to tissue from people who did not carry this diagnosis prior to their death.

Their results linked two main findings emerging from analyses of brain tissue in schizophrenia: abnormalities in the inhibitory neurons within the cortex and increases in neurons in white matter below the cortex.

"Our observations challenge the long held theory that increased neurons in the white matter might be remaining from a transient layer of cells," explained Prof. Cyndi Shannon Weickert and Dr. Samantha Fung. "We suggest that, in schizophrenia, inhibitory neurons that were travelling to the cortex might actually be stuck at some stage in their development."

This study's findings highlight the importance of brain development for the emergence of symptoms associated with schizophrenia. As noted by Dr. John Krystal, Editor of Biological Psychiatry, "this study highlights the importance for schizophrenia of better understanding the molecular switches that control the migration of nerve cells and the development of the connections between nerve cells."

If scientists understood the molecular factors that prevented the neurons from migrating into the cortex, they might be able to develop treatments that prevented the inhibitory neurons from getting "stuck" in the white matter.


'/>"/>

Contact: Chris J. Pfister
C.Pfister@elsevier.com
215-239-3266
Elsevier
Source:Eurekalert

Related medicine news :

1. Researchers identify a molecular switch that controls neuronal migration in the developing brain
2. MessageSolution Releases Enterprise Migration System for GroupWise, Advancing its Technology Leading Position for Enterprise Information Archiving and Migration
3. Exploitation of Overseas Nannies and Caregivers Could Continue Despite New Canadian Immigration Laws
4. ACS Webinar focuses on immigration law for scientific professionals
5. Impact Systems Successfully Completes EMC Documentum Migration for Global Pharmaceutical Client
6. Salaries, demand and career opportunities contribute to global nursing faculty migration
7. Scientists discover key to Christmas Islands red crab migration
8. More Than Half of Pediatricians Make Diagnostic Errors: Survey
9. Planned Parenthood Sex Ed Program Is an Assault on Parental Rights
10. Bioniche Achieves Two Additional Milestones Under Licensing Agreement; Endo Takes up Global Rights
11. GNC Announces Entry to Chinas Nutritional Products in Partnership with Bright Food
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
(Date:6/25/2016)... City, Oklahoma (PRWEB) , ... June 25, 2016 ... ... helping both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic ... the Oklahoma City area —Johnson is one of the first doctors to perform ...
(Date:6/24/2016)... , ... June 24, 2016 , ... A recent ... most people are unfamiliar with. The article goes on to state that individuals are ... many of these less common operations such as calf and cheek reduction. The Los ...
(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... 24, 2016 , ... Dr. Amanda Cheng, an orthodontist ... has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be used ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 2016 Jazz Pharmaceuticals plc (Nasdaq: ... Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended ("HSR"), ... Inc. ("Celator"; Nasdaq: CPXX ) expired effective ... As previously announced on May 31, 2016, ... agreement under which Jazz Pharmaceuticals has commenced a tender ...
(Date:6/24/2016)... , June 24, 2016  Consumers have taken ... regulators/payers have placed more emphasis on patient outcomes. ... support programs in the pharmaceutical industry have evolved ... Consequently, pharmaceutical companies are focusing on becoming more ... providing products and services that improve health. ...
(Date:6/24/2016)... 24, 2016   Bay Area Lyme Foundation ... Dean Center for Tick Borne Illness , Harvard ... MIT Hacking Medicine, University of California, Berkeley, and ... the five finalists of Lyme Innovation , ... than 100 scientists, clinicians, researchers, entrepreneurs, and investors ...
Breaking Medicine Technology: