Navigation Links
Neuronal migration errors: Right cells, wrong place
Date:1/4/2011

Philadelphia, PA, 4 January 2011 - Normally, cortical nerve cells or neurons reside in the brain's gray matter with only a few scattered neurons in the white matter, but some people with schizophrenia have a higher number of neurons in the white matter. Neuronal migration errors may arise in schizophrenia as a consequence of both genetic and environmental factors.

The phenomenon of aberrant cellular localization has now been studied in detail in a paper by Yang and colleagues, published in the current issue of Biological Psychiatry.

Using a specialized technique that involves staining cells, the researchers were able to determine the distribution of nerve cells in brain tissue from people who had been diagnosed with schizophrenia in comparison to tissue from people who did not carry this diagnosis prior to their death.

Their results linked two main findings emerging from analyses of brain tissue in schizophrenia: abnormalities in the inhibitory neurons within the cortex and increases in neurons in white matter below the cortex.

"Our observations challenge the long held theory that increased neurons in the white matter might be remaining from a transient layer of cells," explained Prof. Cyndi Shannon Weickert and Dr. Samantha Fung. "We suggest that, in schizophrenia, inhibitory neurons that were travelling to the cortex might actually be stuck at some stage in their development."

This study's findings highlight the importance of brain development for the emergence of symptoms associated with schizophrenia. As noted by Dr. John Krystal, Editor of Biological Psychiatry, "this study highlights the importance for schizophrenia of better understanding the molecular switches that control the migration of nerve cells and the development of the connections between nerve cells."

If scientists understood the molecular factors that prevented the neurons from migrating into the cortex, they might be able to develop treatments that prevented the inhibitory neurons from getting "stuck" in the white matter.


'/>"/>

Contact: Chris J. Pfister
C.Pfister@elsevier.com
215-239-3266
Elsevier
Source:Eurekalert

Related medicine news :

1. Researchers identify a molecular switch that controls neuronal migration in the developing brain
2. MessageSolution Releases Enterprise Migration System for GroupWise, Advancing its Technology Leading Position for Enterprise Information Archiving and Migration
3. Exploitation of Overseas Nannies and Caregivers Could Continue Despite New Canadian Immigration Laws
4. ACS Webinar focuses on immigration law for scientific professionals
5. Impact Systems Successfully Completes EMC Documentum Migration for Global Pharmaceutical Client
6. Salaries, demand and career opportunities contribute to global nursing faculty migration
7. Scientists discover key to Christmas Islands red crab migration
8. More Than Half of Pediatricians Make Diagnostic Errors: Survey
9. Planned Parenthood Sex Ed Program Is an Assault on Parental Rights
10. Bioniche Achieves Two Additional Milestones Under Licensing Agreement; Endo Takes up Global Rights
11. GNC Announces Entry to Chinas Nutritional Products in Partnership with Bright Food
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... ... ... LINET, an international leader in healthcare technology and a global supplier of hospital ... , Perfectly suitable for labor, delivery, recovery and postpartum; the revolutionary design of the ... of childbirth. The AVE 2 has many features that help make the birthing process ...
(Date:7/20/2017)... Waco, TX (PRWEB) , ... July 19, 2017 , ... ... announce the availability of temporomandibular joint (TMJ) treatment and dental implants in ... the TRIOS® intraoral scanner and the T-Scan™ by Tekscan®, they can capture details in ...
(Date:7/20/2017)... ... 19, 2017 , ... Adolfson & Peterson Construction (AP) continues ... As a leader in healthcare construction, AP has successfully built several well-known medical ... Midwest with Josh now on board. , Josh brings over nine years ...
(Date:7/20/2017)... ... ... a fun-filled, action-packed memoir of adventures. “Fidget” is the creation of published author, Carol ... summa cum laude graduate of Gardner Webb University. She has won numerous awards during ... public school, Lynn continued to pursue her love for music through playing piano, harp, ...
(Date:7/18/2017)... , ... July 18, 2017 , ... ... compliance and commercialization, has just announced two more sessions of its “From the ... into risk management activities. Led by David Cronin, Cognition’s CEO, the half-hour public ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... -- RK Logistics Group, Inc. was awarded California ... Fremont, CA headquarters facility where it provides ... San Jose for hi-tech, pharmaceutical and biomedical ... with its Fremont Innovation District, is excited to strategically partner ... to the hundreds of biotech, pharma and biomed companies throughout ...
(Date:7/11/2017)... has awarded grants totaling more than $2 million to 16 ... Hemophilia Awards Program (BHAP). Four U.S. clinicians and researchers from ... Uniformed Services University of the Health Sciences in ... announced last night during a reception at the International Society ... Germany . ...
(Date:7/10/2017)... CLEVELAND , July 10, 2017  US medical ... billion in 2021, according to Medical Equipment ... released by Freedonia Focus Reports. Continued increases in demand ... the aging of the population and supported by gains ... associated equipment and supplies. New product introductions will also ...
Breaking Medicine Technology: