Navigation Links
Neuron-nourishing cells appear to retaliate in Alzheimer's
Date:5/22/2012

AUGUSTA, Ga. When brain cells start oozing too much of the amyloid protein that is the hallmark of Alzheimer's disease, the astrocytes that normally nourish and protect them deliver a suicide package instead, researchers report.

Amyloid is excreted by all neurons, but rates increase with aging and dramatically accelerate in Alzheimer's. Astrocytes, which deliver blood, oxygen and nutrients to neurons in addition to hauling off some of their garbage, get activated and inflamed by excessive amyloid.

Now researchers have shown another way astrocytes respond is by packaging the lipid ceramide with the protein PAR-4, which independently can do damage but together are a more "deadly duo," said Dr. Erhard Bieberich, biochemist at the Medical College of Georgia at Georgia Health Sciences University.

"If the neuron makes something toxic and dumps it at your door, what would you do?" said Bieberich, corresponding author of the study published in the Journal of Biological Chemistry. "You would probably do something to defend yourself."

The researchers hypothesize that this lipid-coated package ultimately kills them both, which could help explain the brain-cell death and shrinkage that occurs in Alzheimer's. "If the astrocytes die, the neurons die," Bieberich said, noting studies suggest that excess amyloid alone does not kill brain cells. "There must be a secondary process toxifying the amyloid; otherwise the neuron would self-intoxicate before it made a big plaque," he said. "The neuron would die first."

One of many avenues for future pursuit include whether a ceramide antibody could be a viable Alzheimer's treatment. In the researchers' studies of brain cells of humans with Alzheimer's as well as an animal model of the disease, antibodies to ceramide and Par-4 prevented astrocytes' amyloid-induced death.

Ceramide and Par-4 get packaged in lipid-coated vesicles called exosomes; all cells secrete thousa
'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Study: Heart damage after chemo linked to stress in cardiac cells
2. Scientists discover marker to identify, attack breast cancer stem cells
3. All cancer cells are not created equal
4. Drug kills cancer cells by restoring faulty tumor suppressor
5. Rutgers team discovers novel approach to stimulate immune cells
6. Mayo Clinic: Exhaustion renders immune cells less effective in cancer treatment
7. Cancer Cells in Bloodstream Show Great Diversity: Study
8. Scripps Research scientists show how memory B cells stay in class to fight different infections
9. Gut flora affects maturation of B cells in infants
10. Researchers Rejuvenate Blood-Forming Stem Cells in Mice
11. Presence of fetal cells in women lowers risk of breast cancer but raises risk of colon cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Neuron-nourishing cells appear to retaliate in Alzheimer's
(Date:7/14/2014)... Texas (PRWEB) July 14, 2014 The ... encourage investment in the Global Mobile Health Solutions market. ... in the Health IT for Economic and Clinical Health ... February 2009. , Analysts forecast the Global Mobile ... of 34.88 percent over the period 2013-2018. According to ...
(Date:7/14/2014)... The report “Intelligent Building Automation Technologies ... Safety, Facility Management], IT Technologies & Industry Verticals ... - 2019)” defines and segments the IBAS market ... forecasting of revenues. The report also identifies the ... impacting it, along with the technology roadmap and ...
(Date:7/14/2014)... Physical fitness may buffer some of the adverse health ... study by researchers from the American Cancer Society, The ... appears in the journal Mayo Clinic Proceeding s, ... obesity and blood markers associated with cardiovascular disease is ... Sedentary behavior has been linked to an increase risk ...
(Date:7/14/2014)... TX (PRWEB) July 14, 2014 ... heart valves market in Americas. The analysis includes ... the 2007–2020 period and key company share data ... US, Canada, Brazil and Mexico. It uses data ... secondary research and in-house analysis. , Scope, ...
(Date:7/14/2014)... Secure Decisions, a leading provider of ... the Software Assurance Marketplace (SWAMP) to build a powerful ... drives everyday life. , The SWAMP, implemented by a ... Morgridge Institute for Research, is funded by the Department ... practices by building a free facility with a diverse ...
Breaking Medicine News(10 mins):Health News:Mobile Health Solutions Market to Grow at 34.88% CAGR by 2018, Says a New Research Report at Sandlerresearch.org 2Health News:Mobile Health Solutions Market to Grow at 34.88% CAGR by 2018, Says a New Research Report at Sandlerresearch.org 3Health News:Mobile Health Solutions Market to Grow at 34.88% CAGR by 2018, Says a New Research Report at Sandlerresearch.org 4Health News:Intelligent Building Automation Technologies Market Worth $74.8 Billion by 2019 - New Report by MarketsandMarkets 2Health News:Intelligent Building Automation Technologies Market Worth $74.8 Billion by 2019 - New Report by MarketsandMarkets 3Health News:Intelligent Building Automation Technologies Market Worth $74.8 Billion by 2019 - New Report by MarketsandMarkets 4Health News:Physical fitness associated with less pronounced effect of sedentary behavior 2Health News:Americas Transcatheter Heart Valves Market 2020 Forecasts in New Research Report at LifeScienceIndustryResearch.com 2Health News:Americas Transcatheter Heart Valves Market 2020 Forecasts in New Research Report at LifeScienceIndustryResearch.com 3Health News:Americas Transcatheter Heart Valves Market 2020 Forecasts in New Research Report at LifeScienceIndustryResearch.com 4Health News:Madison-based SWAMP, Secure Decisions partner to enhance software security 2Health News:Madison-based SWAMP, Secure Decisions partner to enhance software security 3
... Inc. (R) (HMS) has been closely following ... as it unfolds, especially its impact on ... yesterday on ARRA, even with the up-front investment required ... electronic health record (EHR) technology if they are to ...
... - Predictive medicine company PreMD Inc. (TSX: PMD; PREMF.pk) ... , "Over the last while we have faced significant ... not currently able to continue to finance our clinical ... CEO. "We will be moving to a skeleton staff ...
... Oncology, Inc. ("US Oncology" or "the,Company"), one of the ... million, EBITDA of $52.3 million, Adjusted EBITDA,of $55.2 million, ... of $64.2,million for the three months ended December 31, ... ended December 31, 2008, prior to a first quarter ...
... Coalition Seeks to Increase Public Awareness and Research to ... February 28 To Be Observed Around the World With ... BioMarin Pharmaceutical Inc. (Nasdaq: BMRN ) ... of organizations led by the National Organization for Rare ...
... Manitoba and CINCINNATI, Feb. 26, 2009 Reliance,Products LP ... announce that the U.S.,Environmental Protection Agency (EPA) has approved ... the removal of arsenic, the parasites,Cryptosporidium and Giardia, and ... http://www.newscom.com/cgi-bin/prnh/20090115/CLTH035LOGO-a ) , The EPA ...
... NEW YORK, Feb 26 Our faces are our ... emotions and are connected with three out of the ... But what happens when what you see in the ... Multimedia News Release, go to: http://www.prnewswire.com/mnr/aafprs/35820/ If you ...
Cached Medicine News:Health News:HMS Responds to American Recovery and Reinvestment Act of 2009 2Health News:PreMD Reduces Staffing, Operations - FDA Appeal Still in Process 2Health News:PreMD Reduces Staffing, Operations - FDA Appeal Still in Process 3Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 2Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 3Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 4Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 5Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 6Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 7Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 8Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 9Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 10Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 11Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 12Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 13Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 14Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 15Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 16Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 17Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 18Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 19Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 20Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 21Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 22Health News:US Oncology Reports Fourth Quarter and Yearend 2008 Results 23Health News:BioMarin Supports Observance of Rare Disease Day February 28 2Health News:BioMarin Supports Observance of Rare Disease Day February 28 3Health News:BioMarin Supports Observance of Rare Disease Day February 28 4Health News:Reliance Products and Procter & Gamble Announce EPA Approval of New Claims for PUR Purifier of Water 2Health News:Reliance Products and Procter & Gamble Announce EPA Approval of New Claims for PUR Purifier of Water 3Health News:Video: Facing the Facts - What You Need to Know About Facial Plastic Surgery 2
(Date:7/14/2014)... 14, 2014  Mylan Inc. (NASDAQ: MYL ) ... with Abbott (NYSE: ABT ... non-U.S. developed markets specialty and branded generics business ("the Assets") ... will receive 105 million shares of the combined company ... $50.20 on Friday, July 11, 2014, representing an approximately 21% ...
(Date:7/13/2014)... July 13, 2014  Eli Lilly and Company ... from its non-clinical study in genetically engineered mice ... the beta-amyloid antibody N3pG and beta-secretase inhibitor BACE ... more effective in removing clumps of amyloid-beta protein ... thought to lead to Alzheimer,s disease (AD) – ...
(Date:7/11/2014)... , July 11, 2014 The consumer ... evolving across industry sectors to better identify winning ... ways to engage with and understand consumers, as ... and make critical purchasing decisions. ... Practices, LLC, one area where organizations can observe ...
Breaking Medicine Technology:Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 2Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 3Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 4Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 5Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 6Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 7Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 8Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 9Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 10Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 11New Data Shows Combination Therapy is More Effective than Monotherapy in Removing Beta-Amyloid Plaques from the Brains of Mice 2New Data Shows Combination Therapy is More Effective than Monotherapy in Removing Beta-Amyloid Plaques from the Brains of Mice 3New Technologies Transforming Consumer Marketing Research Playbook 2