Navigation Links
Neuron-nourishing cells appear to retaliate in Alzheimer's
Date:5/22/2012

AUGUSTA, Ga. When brain cells start oozing too much of the amyloid protein that is the hallmark of Alzheimer's disease, the astrocytes that normally nourish and protect them deliver a suicide package instead, researchers report.

Amyloid is excreted by all neurons, but rates increase with aging and dramatically accelerate in Alzheimer's. Astrocytes, which deliver blood, oxygen and nutrients to neurons in addition to hauling off some of their garbage, get activated and inflamed by excessive amyloid.

Now researchers have shown another way astrocytes respond is by packaging the lipid ceramide with the protein PAR-4, which independently can do damage but together are a more "deadly duo," said Dr. Erhard Bieberich, biochemist at the Medical College of Georgia at Georgia Health Sciences University.

"If the neuron makes something toxic and dumps it at your door, what would you do?" said Bieberich, corresponding author of the study published in the Journal of Biological Chemistry. "You would probably do something to defend yourself."

The researchers hypothesize that this lipid-coated package ultimately kills them both, which could help explain the brain-cell death and shrinkage that occurs in Alzheimer's. "If the astrocytes die, the neurons die," Bieberich said, noting studies suggest that excess amyloid alone does not kill brain cells. "There must be a secondary process toxifying the amyloid; otherwise the neuron would self-intoxicate before it made a big plaque," he said. "The neuron would die first."

One of many avenues for future pursuit include whether a ceramide antibody could be a viable Alzheimer's treatment. In the researchers' studies of brain cells of humans with Alzheimer's as well as an animal model of the disease, antibodies to ceramide and Par-4 prevented astrocytes' amyloid-induced death.

Ceramide and Par-4 get packaged in lipid-coated vesicles called exosomes; all cells secrete thousa
'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Study: Heart damage after chemo linked to stress in cardiac cells
2. Scientists discover marker to identify, attack breast cancer stem cells
3. All cancer cells are not created equal
4. Drug kills cancer cells by restoring faulty tumor suppressor
5. Rutgers team discovers novel approach to stimulate immune cells
6. Mayo Clinic: Exhaustion renders immune cells less effective in cancer treatment
7. Cancer Cells in Bloodstream Show Great Diversity: Study
8. Scripps Research scientists show how memory B cells stay in class to fight different infections
9. Gut flora affects maturation of B cells in infants
10. Researchers Rejuvenate Blood-Forming Stem Cells in Mice
11. Presence of fetal cells in women lowers risk of breast cancer but raises risk of colon cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Neuron-nourishing cells appear to retaliate in Alzheimer's
(Date:7/31/2014)... 2014 FORT LAUDERDALE, FLORIDA – ... leading US Joint Commission Accredited teleradiology and telemedicine ... technologically advanced consumer storage and sharing platform for ... providing valued members the use of its Cloud-based ... already offered by SecondOpinions.com®. , Wide-spread radiologic ...
(Date:7/31/2014)... Lauderale, FL (PRWEB) July 31, 2014 ... accepting referrals of insurance patients seeking massage therapy in ... company provides an option for Licensed Massage Therapists who ... refer these patients to BWT. Should a patient request ... the referral, BWT can then contract the therapist to ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 What’s ... practice provider? Community Health Center of Snohomish answers ... Pediatricians vs. Family Doctors ”. Many adults can ... available to them. Community Health Center hopes to ... and differences between the two. , To ...
(Date:7/31/2014)... When it comes to aesthetics and wellness, ... As such, Natalie Sharp's Pure Vitality Rx ... new, more focused direction and to provide the latest ... Pure Vitality Rx is Oyster Bay's premier aesthetic, anti-aging ... of services primarily dedicated to women. Services include injectables ...
(Date:7/31/2014)... Some pain relief medications can be as ... Every day, 46 people in the U.S. die from ... people are admitted to an emergency room because of opioid ... the dangers of prescription and over-the-counter painkillers and is calling ... more to make these drugs safer. , The full report, ...
Breaking Medicine News(10 mins):Health News:SECONDOPINIONS.COM® Introduces Innovative Cloud-Based Medical Imaging Exchange Service for Easy Upload, Access and Sharing Anytime/Anywhere 2Health News:SECONDOPINIONS.COM® Introduces Innovative Cloud-Based Medical Imaging Exchange Service for Easy Upload, Access and Sharing Anytime/Anywhere 3Health News:Body Well Therapy Invites Massage Therapists Nationwide to "Bring Your Own Insurance Clients" 2Health News:Body Well Therapy Invites Massage Therapists Nationwide to "Bring Your Own Insurance Clients" 3Health News:Community Health Center of Snohomish County Reveals the Differences Between Pediatricians and Family Practice Providers 2Health News:Natalie Sharp's Pure Vitality Rx Upgrade - Partnership With Shangri-La Spa and Website Facelift! 2Health News:Consumer Reports Warns Against the Risks of Prescription and Over-The-Counter Painkillers 2Health News:Consumer Reports Warns Against the Risks of Prescription and Over-The-Counter Painkillers 3
... , FARMINGDALE, N.Y., Sept. 2 Misonix, ... invasive ultrasonic medical device technology, which in Europe is used ... health conditions, today announced the restructuring and expansion of its ... created; one for sales and service of the Sonablate(R) 500 ...
... Fox Chase Cancer Center has received an $8 million ... the National Institutes of Health (NCRR/NIH) to expand their ... will support advanced research into the fundamental biological processes ... new treatments. The funds for the grant were made ...
... the total mortality rate from unintentional injury increased in the ... increases were seen in some subgroups analyzed by age, race, ... Hopkins Bloomberg School of Public Health,s Center for Injury Research ... and 64 years old experienced a 230 percent increase in ...
... - Researchers are developing computer models to comb through ... or insurance claims data to automatically classify them based ... to identify the most important causes of injuries so ... of injuries in society," said Mark Lehto, an associate ...
... Washington Post study, approximately 20% of U.S. soldiers returning ... are a substantial number with post-traumatic stress disorder (PTSD), ... has become unacceptable to Army commanders and the soldiers, ... University, however, doctors will now be able to forecast ...
... ... , ... -- Spend one hour with Delaine Anderson, and it,s clear she does not shrink from life,s ... in different parts of the country before that. She even lived seven years in Greece, where ...
Cached Medicine News:Health News:Misonix Restructures and Expands Sales Organization in Europe 2Health News:Misonix Restructures and Expands Sales Organization in Europe 3Health News:Misonix Restructures and Expands Sales Organization in Europe 4Health News:Fox Chase Cancer Center receives $8 million NIH grant to expand laboratory animal research facility 2Health News:Deaths from unintentional injuries increase for many groups 2Health News:New computer models aim to classify, help reduce injury accidents 2Health News:Keeping the suicidal soldier alive 2Health News:Twitter Users Can Follow in Real Time as Local Woman Receives Cyberknife Treatment for Lung Cancer 2Health News:Twitter Users Can Follow in Real Time as Local Woman Receives Cyberknife Treatment for Lung Cancer 3Health News:Twitter Users Can Follow in Real Time as Local Woman Receives Cyberknife Treatment for Lung Cancer 4
(Date:7/30/2014)...  El Camino Hospital, a leader in the use ... Leaf Patient Monitoring system to help prevent hospital-acquired pressure ... susceptible to bed sores. The decision was ... the system, which showed dramatic improvement in compliance with ... the one of the most effect ways to prevent ...
(Date:7/30/2014)... PITTSBURGH , July 30, 2014   ... Markets Groups Inc.: OTC Pink: UPZS), a Delaware ... a distribution agreement with Larasan Pharmaceutical Corporation ("Larasan"), a ... products.  According to the agreement, US-based Larasan will ... gourmet 6" frozen pizza through Larasan,s vast distribution ...
(Date:7/30/2014)... SANTA CLARA, Calif. , July 30, 2014 /PRNewswire/ ... innovation economy, released a study today that ... venture-backed biopharma and medical device companies.  According to the ... healthcare saw the biggest potential returns since SVB started ... the year of the IPO.  Built on solid healthcare ...
Breaking Medicine Technology:El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 3Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 2Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 3Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 2Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 3
...  IRIDEX Corporation (Nasdaq: IRIX ) announced ... of IRIDEX, MicroPulse laser therapy.  The study examined ... central serous chorioretinopathy (CSC).(1) The study concluded tissue-sparing ... for CSC, also known as CSR, an eye ...
... Texas, Jan. 25, 2012 UNT Health Science Center ... Myron (Mike) Jacobson, Ph.D., as the founding dean of ... search we were very pleased to recruit a renowned ... academic leader in pharmacy education, and a successful entrepreneur ...
Cached Medicine Technology:IRIDEX MicroPulse™ Laser Therapy Enhances Visual Function in Patients with Central Serous Chorioretinopathy (CSC) 2IRIDEX MicroPulse™ Laser Therapy Enhances Visual Function in Patients with Central Serous Chorioretinopathy (CSC) 3UNT System Names Jacobson Founding Dean of College of Pharmacy 2UNT System Names Jacobson Founding Dean of College of Pharmacy 3
... single-use instruments on the market., Available in standard ... Surgery. , Dual action tips provide maximum ... points to reduce the chance of alternative burn ... eliminates gapping at connection and the need for ...
Disposable sheath for use with 5mm AEM Laparoscopic Instruments ....
... AEM Laparoscopic Instruments incorporate a layered design ... shielded and monitored to prevent stray electrosurgical ... caused by insulation failure or capacitive coupling; ... shield built into all AEM Instruments provides ...
... AEM Laparoscopic Instruments incorporate a layered design ... shielded and monitored to prevent stray electrosurgical ... caused by insulation failure or capacitive coupling; ... shield built into all AEM Instruments provides ...
Medicine Products: