Navigation Links
Neuromed Announces that Merck & Co., Inc. Terminates Research Collaboration and License Agreement for Compounds Targeting N-Type Calcium Channels

CONSHOHOCKEN, PA and VANCOUVER, BC, June 11 /PRNewswire/ - Neuromed Pharmaceuticals Ltd. announced today that it has received notification that Merck & Co., Inc. will terminate the research collaboration and license agreement for novel compounds targeting N-type calcium channels for the treatment of pain and other disorders, which the companies entered into in March of 2006.

"Over the past three years we have had an excellent and extremely productive collaboration with our colleagues at Merck. The molecules generated in our collaboration, while effective in disease models, did not demonstrate the profile needed to enter the next phase of testing, including human clinical trials. We remain confident in our goal to generate a new class of medicines from our platform," said Dr. Christopher Gallen, President & CEO of Neuromed. "Neuromed is a leader in ion channel research and we remain committed to further research and development in this field."

N-type calcium channel blockers represent a potentially novel class of analgesics that are selective for calcium channels involved in pain signal transmission. Calcium channels control the entry of calcium into the neuron. When a pain signal is transmitted, the channel opens and the calcium concentration increases, triggering the release of neurotransmitters from synaptic vesicles, thereby sending the pain signal to the brain where it is perceived as pain.

About Neuromed

Neuromed is a privately held biopharmaceutical company focusing on the development of new and improved pain medicines. Its lead drug candidate is EXALGO(TM) (hydromorphone HCl) Extended-Release Tablets. In addition to its N-type program, Neuromed is also developing oral drug candidates to block T-type calcium channels, a new and important target directly involved in pain, epilepsy and hypertension. For more information visit our website at

Neuromed cautions you that statements included in this press release that are not a description of historical facts may be forward-looking statements. Forward-looking statements are only predictions based upon current expectations and involve known and unknown risks and uncertainties. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of release of the relevant information, unless explicitly stated otherwise. Actual results, performance or achievement could differ materially from those expressed in, or implied by, Neuromed's forward-looking statements due to the risks and uncertainties inherent in Neuromed's business including, without limitation, statements about: the progress and timing of its clinical trials; difficulties or delays in development, testing, obtaining regulatory approval, producing and marketing its products; unexpected adverse side effects or inadequate therapeutic efficacy of its products that could delay or prevent product development or commercialization, or that could result in recalls or product liability claims; the scope and validity of patent protection for its products; competition from other pharmaceutical or biotechnology companies; and its ability to obtain additional financing to support its operations. Neuromed does not assume any obligation to update any forward-looking statements.

SOURCE Neuromed Pharmaceuticals Ltd.
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Neuromed Concludes a Special Protocol Assessment (SPA) with FDA for a Pivotal Phase 3 Study on NMED-1077
2. Neuromed Appoints Jeffrey Arcara and Gene Wright to Senior Management Team
3. Nfocus Neuromedical Receives CE Mark for the CardioVasc(TM) Stent-Graft and Delivery System
4. Nfocus Neuromedical Announces Acquisition of StarFire Medical
5. Neuromed Completes Enrollment for Phase 3 Chronic Low Back Pain Clinical Trial of NMED-1077
6. Neuromed Announces Exalgo(TM) (hydromorphone HCl) Extended-Release Tablets (CII) Meets Primary Efficacy Endpoint in Pivotal Phase 3 Trial
7. Nfocus Neuromedical Elects Eric P. Milledge Chairman of Board
8. $10 Million Gift to Transform Neuromedicine at URMC
9. HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness
10. CRC Health Group Announces Acquisition of Bayside Marin Recovery Center, San Rafael
11. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... A ... of bacteria could be effective in fighting methicillin-resistant Staphylococcus aureus (MRSA), one of ... Their study showed that small molecule analogs that target the functions of SecA, ...
(Date:11/30/2015)... , ... November 30, 2015 , ... At Grand Dental ... and convenient setting. , When you have dental problems, you need to turn to ... can effectively diagnose and treat your needs, a friendly dentist who counsels you on ...
(Date:11/30/2015)... , ... November 30, 2015 , ... Using a combination ... prediabetes in American children and adults, according to a new study by researchers at ... of Prediabetes in Children and Adults: Using Combinations of Blood Glucose Tests ,” published ...
(Date:11/30/2015)... ... 30, 2015 , ... Newly reviewed and approved “NJ Top ... He has both advanced training and considerable experience in reconstructive dentistry with ... in cosmetic dentistry. He is an active Spear Education member providing full ...
(Date:11/30/2015)... PA (PRWEB) , ... November 30, 2015 , ... ... to a new study by UPMC and KingMed Diagnostics ... over three years found that consultation with UPMC pathologists resulted in significantly altered ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... --  Nuance Communications, Inc. (NASDAQ: NUAN ) ... (NDSC) today jointly announced a new integrated set of ... American College of Radiology,s (ACR) Imaging 3.0™ tools to ... current and emerging value-based payment models . ... combining clinical decision support, radiology reporting and image sharing ...
(Date:11/30/2015)... -- Booth #4303 – The Imaging Components business of Varian ... array of products in a new booth (#4303) at the ... America in Chicago this ... components "At the Heart of Imaging." Products will include a ... Claymount brand, and computer-aided diagnostic software from MeVis as well ...
(Date:11/30/2015)... -- Hanger, Inc. (NYSE: HGR ) (the "Company") today ... its previously announced consent solicitation (as amended and restated, ... amount 7⅛% Senior Notes due 2018 (the "Notes") to ... pursuant to the Consent Solicitation, (ii) the proposed increased ... date of the Consent Solicitation.    ...
Breaking Medicine Technology: