Navigation Links
Neurologists identify potential biomarker of cognitive decline for earlier diagnosis of disease
Date:10/31/2011

Researchers from the Department of Neurology at NYU Langone Medical Center identified for the first time that changes in the tissue located at the junction between the outer and inner layers of the brain, called "blurring", may be an important, non-invasive biomarker for earlier diagnosis and the development of new therapies for degenerative brain conditions, such as multiple sclerosis. The study was published in the Oct. 26th issue of the Journal of Neuroscience.

"The findings are significant because this is the first time we have mapped the distinct relationship between blurring of the boundary in the left hemisphere, where verbal language skills are managed, and the impact that changes in this area have on cognitive ability," said Karen Blackmon, PhD, research assistant professor, Department of Neurology and lead author of the study. "The fact that this occurs in healthy brains and appears to be connected with a person's cognitive function has significant implications for our ability to diagnose brain disease earlier and for the potential development of new therapies."

In the study, 32 healthy adults had an MRI scan of their brain. The images were enhanced to highlight the junction between the area of the brain where neurons control cognitive and motor function, or "grey matter", and the area where longer, myelin-insulated axon cells responsible for efficient transmission of electrical signals, or "white matter", exist. When neurons develop incorrectly among the axons (which can happen in-utero or after a brain injury) they are visible as "blurring" along the edge of this junction on an MRI. Blurring is associated with impaired cognitive conditions, such as epilepsy and Alzheimer's disease, but has never been identified in individuals without these conditions.

The researchers administered standardized intelligence tests and scored the participants verbal, visual, and spatial cognitive abilities. These abilities are controlled by a distinct area in the brain's left hemisphere and are an established measure of overall cognitive function.

The researchers found that not only did blurring exist in brains without a degenerative condition, but when the verbal language assessment scores were linked with the MRI data, there was a strong relationship between the amount of blurring and a decreasing level of verbal language skill. For more information about the Department of Neurology at NYU Langone Medical Center go to http://www.med.nyu.edu/neurology.


'/>"/>
Contact: Craig Andrews
craig.andrews@nyumc.org
212-404-3511
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Related medicine news :

1. First clinical trial of gene therapy for pain reported by U-M neurologists
2. Neurologists develop software application to help identify subtle epileptic lesions
3. Concussion Should Sideline Athletes: Neurologists
4. US neurologists agree on protocols for treatment of infantile spasms
5. IHME develops fast, affordable ways for countries to better identify causes of death in populations
6. Researchers identify potential risk factors for severe altitude sickness
7. Scientists Identify Gene Linked to Cold Sores
8. Blood test could identify smokers at higher risk for heart disease, UT Southwestern researchers find
9. Mine-hunting software helping doctors to identify rare cells in human cancer
10. New tool helps identify prostate cancer patients with highest risk of death
11. More screening needed to identify depression, vision loss after mild stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... Philadelphia, PA (PRWEB) , ... January 24, 2017 , ... ... America, but the co-founder of the organization End Distracted Driving , Joel Feldman, ... Today. , Feldman's story was featured in one of the top newspapers in circulation ...
(Date:1/24/2017)... ... January 24, 2017 , ... Center for Hispanic Leadership (CHL) ... named Hector M. Chavez, Manager, Employee & Labor Relations at City of Hope ... Hispanic Leader of the Month. City of Hope is committed to stay out in ...
(Date:1/24/2017)... N.C. (PRWEB) , ... January 24, 2017 , ... ... Administration is the focus of a new report from the Frank Hawkins ... Business School. , Influential business leaders, academics and policy makers identified concrete solutions ...
(Date:1/24/2017)... , ... January 24, 2017 , ... ... Need to Thrive , Well-meaning studies such as the Fordham Institute’s High ... better serve top students, such as including gifted or high-achieving students as a ...
(Date:1/24/2017)... ... 2017 , ... The NewKILO JRP, a three-year project of the European Metrology ... Union (EU), was completed in May 2015. The future definition will require the unit ... air, which presents some challenges to establishing traceability to the mass scale. , This ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... , Jan. 24, 2017 Data4Cure, Inc. ... studies using its Biomedical Intelligence® Cloud - a semantic ... a multitude of genomic, molecular and clinical data that ... presented at a session hosted by Data4Cure at the ... View, CA. The company,s Biomedical ...
(Date:1/24/2017)... and PUNE, India , January ... published by Allied Market Research, titled, "Cold Chain Logistics ... Confectionary, Dairy & Frozen Dessert, Meat, Fish & Sea ... Analysis and Industry Forecasts, 2014-2022," projects that the global ... million by 2022, growing at a CAGR of 16% ...
(Date:1/24/2017)... 24, 2017 Trifecta Clinical , a ... appointing Rick Ward to Vice President of ... is also announcing the promotion of Ericka Atkinson ... Rick joins Trifecta from Greenphire where he ... senior business development positions within the healthcare industry throughout ...
Breaking Medicine Technology: