Navigation Links
Neurologists identify potential biomarker of cognitive decline for earlier diagnosis of disease
Date:10/31/2011

Researchers from the Department of Neurology at NYU Langone Medical Center identified for the first time that changes in the tissue located at the junction between the outer and inner layers of the brain, called "blurring", may be an important, non-invasive biomarker for earlier diagnosis and the development of new therapies for degenerative brain conditions, such as multiple sclerosis. The study was published in the Oct. 26th issue of the Journal of Neuroscience.

"The findings are significant because this is the first time we have mapped the distinct relationship between blurring of the boundary in the left hemisphere, where verbal language skills are managed, and the impact that changes in this area have on cognitive ability," said Karen Blackmon, PhD, research assistant professor, Department of Neurology and lead author of the study. "The fact that this occurs in healthy brains and appears to be connected with a person's cognitive function has significant implications for our ability to diagnose brain disease earlier and for the potential development of new therapies."

In the study, 32 healthy adults had an MRI scan of their brain. The images were enhanced to highlight the junction between the area of the brain where neurons control cognitive and motor function, or "grey matter", and the area where longer, myelin-insulated axon cells responsible for efficient transmission of electrical signals, or "white matter", exist. When neurons develop incorrectly among the axons (which can happen in-utero or after a brain injury) they are visible as "blurring" along the edge of this junction on an MRI. Blurring is associated with impaired cognitive conditions, such as epilepsy and Alzheimer's disease, but has never been identified in individuals without these conditions.

The researchers administered standardized intelligence tests and scored the participants verbal, visual, and spatial cognitive abilities. These abilities are controlled by a distinct area in the brain's left hemisphere and are an established measure of overall cognitive function.

The researchers found that not only did blurring exist in brains without a degenerative condition, but when the verbal language assessment scores were linked with the MRI data, there was a strong relationship between the amount of blurring and a decreasing level of verbal language skill. For more information about the Department of Neurology at NYU Langone Medical Center go to http://www.med.nyu.edu/neurology.


'/>"/>
Contact: Craig Andrews
craig.andrews@nyumc.org
212-404-3511
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Related medicine news :

1. First clinical trial of gene therapy for pain reported by U-M neurologists
2. Neurologists develop software application to help identify subtle epileptic lesions
3. Concussion Should Sideline Athletes: Neurologists
4. US neurologists agree on protocols for treatment of infantile spasms
5. IHME develops fast, affordable ways for countries to better identify causes of death in populations
6. Researchers identify potential risk factors for severe altitude sickness
7. Scientists Identify Gene Linked to Cold Sores
8. Blood test could identify smokers at higher risk for heart disease, UT Southwestern researchers find
9. Mine-hunting software helping doctors to identify rare cells in human cancer
10. New tool helps identify prostate cancer patients with highest risk of death
11. More screening needed to identify depression, vision loss after mild stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... Gastro Health ... partnership to prep patients for colonoscopy at the HyGIeaCare® Center that is to ... Miami, FL. , The HyGIeaCare® Prep, cleared by the U.S. Food ...
(Date:3/24/2017)... ... 2017 , ... “Finding Christ Through Social Media: Year One ... the writer’s path toward true communion with God. “Finding Christ Through Social Media: ... creation of published author Lea Michelle Johnson, a follower of Christ, wife and ...
(Date:3/24/2017)... ... March 24, 2017 , ... “The Communion of ... people of God in congregations across the United States. “The Communion of ... in 1964 who has served congregations in seven states throughout his long career ...
(Date:3/23/2017)... ... 23, 2017 , ... A recent report from the National Council on Teacher ... NCTQ report suggests, based on a review of GPA and SAT/ACT requirements at 221 ... the U.S. It argues that this higher bar should be set by states, by ...
(Date:3/23/2017)... ... March 23, 2017 , ... Texas Physical Therapy Specialists (TexPTS) ... Road in Building 2. The clinic is the group’s second in New Braunfels and ... the company’s second New Braunfels location brings things full circle for the group, “It’s ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... -- Research and Markets has announced the addition of ... report to their offering. ... The report provides separate comprehensive analytics for the US, Canada ... Asia-Pacific , Latin America , and ... 2015 through 2022. Also, a six-year historic analysis is provided for these ...
(Date:3/24/2017)... , March 24, 2017  Eli Lilly ... announced plans to invest $850 million in its ... facilities across its U.S. enterprise, including research laboratories, ... investments are being driven by demand for Lilly ... potential medicines in development targeting cancer, pain, diabetes ...
(Date:3/24/2017)... , March 23, 2017  Mirabilis Medical, ... advanced medical technology for non-invasive surgery, announced today ... System for treatment of uterine fibroids throughout the ... had received approval from the US Food and ... the Mirabilis System in the United States.  The ...
Breaking Medicine Technology: