Navigation Links
Neurologists identify potential biomarker of cognitive decline for earlier diagnosis of disease
Date:10/31/2011

Researchers from the Department of Neurology at NYU Langone Medical Center identified for the first time that changes in the tissue located at the junction between the outer and inner layers of the brain, called "blurring", may be an important, non-invasive biomarker for earlier diagnosis and the development of new therapies for degenerative brain conditions, such as multiple sclerosis. The study was published in the Oct. 26th issue of the Journal of Neuroscience.

"The findings are significant because this is the first time we have mapped the distinct relationship between blurring of the boundary in the left hemisphere, where verbal language skills are managed, and the impact that changes in this area have on cognitive ability," said Karen Blackmon, PhD, research assistant professor, Department of Neurology and lead author of the study. "The fact that this occurs in healthy brains and appears to be connected with a person's cognitive function has significant implications for our ability to diagnose brain disease earlier and for the potential development of new therapies."

In the study, 32 healthy adults had an MRI scan of their brain. The images were enhanced to highlight the junction between the area of the brain where neurons control cognitive and motor function, or "grey matter", and the area where longer, myelin-insulated axon cells responsible for efficient transmission of electrical signals, or "white matter", exist. When neurons develop incorrectly among the axons (which can happen in-utero or after a brain injury) they are visible as "blurring" along the edge of this junction on an MRI. Blurring is associated with impaired cognitive conditions, such as epilepsy and Alzheimer's disease, but has never been identified in individuals without these conditions.

The researchers administered standardized intelligence tests and scored the participants verbal, visual, and spatial cognitive abilities. These abilities are controlled by a distinct area in the brain's left hemisphere and are an established measure of overall cognitive function.

The researchers found that not only did blurring exist in brains without a degenerative condition, but when the verbal language assessment scores were linked with the MRI data, there was a strong relationship between the amount of blurring and a decreasing level of verbal language skill. For more information about the Department of Neurology at NYU Langone Medical Center go to http://www.med.nyu.edu/neurology.


'/>"/>
Contact: Craig Andrews
craig.andrews@nyumc.org
212-404-3511
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Related medicine news :

1. First clinical trial of gene therapy for pain reported by U-M neurologists
2. Neurologists develop software application to help identify subtle epileptic lesions
3. Concussion Should Sideline Athletes: Neurologists
4. US neurologists agree on protocols for treatment of infantile spasms
5. IHME develops fast, affordable ways for countries to better identify causes of death in populations
6. Researchers identify potential risk factors for severe altitude sickness
7. Scientists Identify Gene Linked to Cold Sores
8. Blood test could identify smokers at higher risk for heart disease, UT Southwestern researchers find
9. Mine-hunting software helping doctors to identify rare cells in human cancer
10. New tool helps identify prostate cancer patients with highest risk of death
11. More screening needed to identify depression, vision loss after mild stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Sessions in Dallas that it will receive two significant new grants to support ... as PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, ... minimum wage raise to $12 an hour by 2020 and then adjusting it yearly to ... value of the minimum wage, assure the wage floor does not erode again, and make ...
(Date:6/24/2016)... Las Vegas, Nevada (PRWEB) , ... June 24, ... ... their Las Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and ... The Grove, in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... report to their offering. ... a favourable commercial environment for MedImmune to enter. The US ... will serve to drive considerable growth for effective anti-influenza medications. ... cap sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas ... Brasil as the company,s second affiliate in Latin America . ... ... of Astellas Farma Colombia ... ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Surgical Procedure Volumes: Global Analysis (United States, ... Australia, Canada)" report to their offering. ... an essential tool for healthcare business planners, provides surgical ... looks at surgery trends with an in-depth analysis of ...
Breaking Medicine Technology: