Navigation Links
Neurological disorder impacts brain cells differently
Date:11/9/2011

Bergmann glia (support cells found in the cerebellum) and cells in the olivary complex (part of the brainstem controlling body movement).

By creating and comparing mice that expressed the mutant gene only in targeted cells, La Spada said the scientists made two unexpected discoveries: First, when the gene mutation was eliminated from Bergmann glia, neurodegeneration continued unabated and still involved dysfunction and degeneration of the Bergmann glia themselves. Second, when the mutation was excised from Purkinje neurons and the olivary complex, there was significantly less neurological damage and Bergmann glia remained intact.

"The first result highlights the relatively new idea that degeneration goes both ways," said La Spada. "It isn't just neurons becoming affected when their support cells dysfunction. The Bergmann glia didn't express the mutant gene, but they still degenerated. This shows the bilateral relationship between neurons and non-neuronal cells. They're equal partners, in both normal functioning and in disease.

"The second result underscores the relevance of Purkinje cells and the olivary neuron circuit in the brainstem to SCA7. When it's dysfunctional, degeneration occurs. This is crucial for our understanding of this disease, and should enable us to develop more specific therapeutic approaches. Although we have our work cut out for us, we now have a better idea of what we're up against."


'/>"/>
Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Harvard Medical School and EPFL launch program targeting neurological disabilities
2. Researcher tests drugs impact on neurological disease affecting women
3. Cedars-Sinai to hold first annual conference on stem cell therapies for neurological disorders
4. Neurological protein may hold the key to new treatments for depression
5. Elseviers BrainNavigator 3.0 reflects the next step in enhancing neurological research
6. NYU researchers identify new neurological deficit behind lazy eye
7. Scientists explain the neurological process for the recognition of letters and numbers
8. Team led by LA BioMed scientist develops novel approach to study neurological disorders
9. University Hospitals Neurological Institute earns Neuroscience Center of Excellence designation
10. University Hospitals Neurological Institute hosts international epilepsy colloquium
11. Rare disease in Amish children sheds light on common neurological disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Neurological disorder impacts brain cells differently
(Date:4/17/2014)... An international team led by researchers at UC ... which plays a key role in cell division, also ... is the first time the complex has been shown ... cyclin B1/Cdk1 an excellent target to control cellular energy ... research was published online today in the journal ...
(Date:4/17/2014)... find a colored ribbon representing a disease. A pink ribbon ... ribbon does one think of with lung cancer?, Although white ... from the disease, black may be the only one they ... cancer patients, primarily smokers between the ages of 51 to ... often felt by these patients, the emotional toll it can ...
(Date:4/17/2014)... A new study has found that India,s shocking rates ... debt-ridden farmers who are clinging to tiny smallholdings ... ,cash crops, such as cotton and coffee, that are ... supports a range of previous case studies that point ... sector following the ,liberalisation, of the nation,s economy during ...
(Date:4/17/2014)... anti-malarial treatment that lost its status as the leading ... new lease of life, with new research indicating it ... could revive the use of the cheap anti-malarial drug ... claims the lives of more than half a million ... that causes malaria has developed resistance to chloroquine, but ...
(Date:4/16/2014)... HAMPTON, NJ (April 16, 2014): Celldex Therapeutics, Inc. ... Phase 1 study of CDX-1401 in solid tumors, including ... Translational Medicine (Vol 6 Issue 232). The data ... of clinical benefit in patients with very advanced cancers ...
Breaking Medicine News(10 mins):Health News:Dual role: Key cell division proteins also power up mitochondria 2Health News:Unraveling the 'black ribbon' around lung cancer 2Health News:New evidence of suicide epidemic among India's 'marginalized' farmers 2Health News:New evidence of suicide epidemic among India's 'marginalized' farmers 3Health News:Scientists find new way to fight malaria drug resistance 2Health News:Celldex's Phase 1 study of CDX-1401 published in Science Translational Medicine 2Health News:Celldex's Phase 1 study of CDX-1401 published in Science Translational Medicine 3Health News:Celldex's Phase 1 study of CDX-1401 published in Science Translational Medicine 4
... becoming apparent to the Government Health officials, albeit for the ... socks and gearing up to take stock of multi-drug resistant ... a public health initiative , developed by the World Health ... in Maharashtra and Gujarat. 100 MDR-TB cases are envisaged in ...
... at The University of Texas M. D. Anderson Cancer ... prostate cancer patients who are eligible for watchful // ... ,"With the advent of the PSA test, we ... no evidence that early detection means longer survival. Because ...
... recent progress in echocardiography providing doctors with improved imaging ... a // probe into the esophagus, which emits radio ... in enabling a motion picture of the heart, far ... images are capable of offering various options to doctors ...
... women who present to the sex clinic only report ... some women, may present with just the opposite complaints//. ... suffering from the so-called persistent sexual arousal syndrome (PSAS) ... ,Currently, very little is understood about this rare syndrome ...
... you badly in need of blood or are you inclined in ... it//? Either way, the solution for it is just a few ... simple yet amazingly useful venture in 2000. He works for Central ... of the venture too. ,If you're located in Kolkata ...
... is a mere 0.028 percent as compared to the national ... further, the military's top doctor said Thursday. ,"Contracting ... crime," Surgeon Vice Admiral Vijay K. Singh, director general of ... ,The national average of the incidence of HIV/AIDS ...
Cached Medicine News:Health News:New Network To Ease Blood donation In India 2Health News:Incidence Of HIV/AIDS In The Indian Armed Forces Negligible 2
(Date:1/15/2014)... Ky. , Jan. 15, 2014  Manufacturers, suppliers ... must be able to protect their most important ... http://photos.prnewswire.com/prnh/20130716/CL46586LOGO ) Because of ... it steadfastly remains one of the most litigious ...
(Date:1/15/2014)... , Jan. 15, 2014 The Cadence Fitness ... Fitness Center by the Medical Fitness Association, a non-profit ... achieve their full potential. The Cadence Fitness & Health ... western suburbs and second in the Chicagoland area. ...
(Date:1/15/2014)... 15, 2014 Reportlinker.com announces that a ... its catalogue: Global ... Systems -- Focus on End Users ... OBJECTIVES A drug delivery system ...
Breaking Medicine Technology:Intellectual Property Insurance for Medical-related Products and Services 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18
Lyphochek Therapeutic Drug Monitoring Control (TDM) contains over 40 analytes with assayed values at three clinically significant levels....
Lyphochek Urine Metals Control incorporates two levels of critical trace elements, heavy metals and organic metabolites, and is ideal for environmental and industrial testing....
Liquichek Whole Blood Volatiles Control is an assayed liquid control for monitoring volatile compounds. This product is available in 2 levels....
Lyphochek Urine Bone Markers Control is a bilevel human urine based control designed to monitor tests for urinary markers of osteoporosis management and bone resorption....
Medicine Products: