Navigation Links
Neurological disorder impacts brain cells differently
Date:11/9/2011

In a paper published in the Nov. 9 issue of the Journal of Neuroscience, researchers at the University of California, San Diego School of Medicine and University of Washington describe in deeper detail the pathology of a devastating neurological disorder, but also reveal new cellular targets for possibly slowing its development.

Spinocerebellar ataxia type 7 (SCA7) is an inherited neurological disorder in which cells in the cerebellum and brainstem degenerate, resulting in progressive loss of physical coordination and possible blindness. Its pathology is similar to other neurodegenerative diseases like Parkinson's, Huntington's and amyotrophic lateral sclerosis. And like them, it's currently incurable.

The scientists, led by Al La Spada, MD, PhD, chief of the division of genetics in the UC San Diego department of pediatrics, and professor of cellular and molecular medicine, neurosciences and biological sciences, used a variety of transgenic mouse models to show that SCA7 results from genetic dysfunction not just in affected neurons, but also in associated non-neuronal support cells.

"The central nervous system is quite complicated, with neurons interacting with each other and with other cell types. So it shouldn't be a surprise that the disease process is similarly complex," said La Spada, who is also associate director of the UC San Diego Institute for Genomic Medicine. "We show that dysfunction in a variety of cell types contributes to SCA7, and that if you can improve function in any of these cell types, you have a reasonable chance of improving treatment of the disease."

La Spada and colleagues created a transgenic mouse in which the key gene mutation that causes SCA7 could be easily manipulated. The mouse was then bred with other mouse models that eliminated the mutant gene protein from specific cell types affected by SCA7: Purkinje neurons (large cells in the cerebral cortex responsible for motor coordination),
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Harvard Medical School and EPFL launch program targeting neurological disabilities
2. Researcher tests drugs impact on neurological disease affecting women
3. Cedars-Sinai to hold first annual conference on stem cell therapies for neurological disorders
4. Neurological protein may hold the key to new treatments for depression
5. Elseviers BrainNavigator 3.0 reflects the next step in enhancing neurological research
6. NYU researchers identify new neurological deficit behind lazy eye
7. Scientists explain the neurological process for the recognition of letters and numbers
8. Team led by LA BioMed scientist develops novel approach to study neurological disorders
9. University Hospitals Neurological Institute earns Neuroscience Center of Excellence designation
10. University Hospitals Neurological Institute hosts international epilepsy colloquium
11. Rare disease in Amish children sheds light on common neurological disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Neurological disorder impacts brain cells differently
(Date:7/22/2014)... European Bio stimulants Market report defines and segments the ... of revenue. The bio stimulants market in Europe is ... to $940.6 million by 2018, at a CAGR of ... TOC of the Europe Bio stimulants Market report, to ... http://www.micromarketmonitor.com/market/europe-bio-stimulants-1315565884.html , Agriculture contributes to 10% of ...
(Date:7/22/2014)... 2014 Today, Therapy Changes announces the start ... – 18 to help increase their knowledge and ability to ... will learn how to make healthy and positive decisions while ... excitement and adventure, but also a time of major life ... Therapy Changes . , “Teens can at times feel ...
(Date:7/22/2014)... 22, 2014 Alliance Storage ... data archiving solutions, has announced the availability of ... archiving solution. The unique new solution merges optical ... on compliant data archiving across all industries including ... The introduction of the new archiving tier permits ...
(Date:7/22/2014)... July 22, 2014 Thought Technology's ... set of simple tools, designed to help clinicians do ... or no experience with biofeedback. The tools in the ... and elucidate any abnormal patterns to teach them to ... paced world, we are familiar with stress and its ...
(Date:7/22/2014)... from the University of Murcia have studied the ... impulsiveness, a personality trait that causes difficulties in ... stimulus and leads to unplanned actions without considering ... an indicator for predicting the risk of behavioural ... from the University of Murcia analyses whether the ...
Breaking Medicine News(10 mins):Health News:Europe Bio Stimulants Market is Expected to Reach $940.6 Million in 2018 - New Report by MicroMarket Monitor 2Health News:Europe Bio Stimulants Market is Expected to Reach $940.6 Million in 2018 - New Report by MicroMarket Monitor 3Health News:Europe Bio Stimulants Market is Expected to Reach $940.6 Million in 2018 - New Report by MicroMarket Monitor 4Health News:Europe Bio Stimulants Market is Expected to Reach $940.6 Million in 2018 - New Report by MicroMarket Monitor 5Health News:Therapy Changes Announces Teen Support Group Therapy 2Health News:Data Archiving Leader Alliance Storage Technologies Releases Enterprise Class Cloud-Integrated Storage Solution 2Health News:Data Archiving Leader Alliance Storage Technologies Releases Enterprise Class Cloud-Integrated Storage Solution 3Health News:Data Archiving Leader Alliance Storage Technologies Releases Enterprise Class Cloud-Integrated Storage Solution 4Health News:Thought Technology to Present Software for Stress Control at the 2014 American Psychological Association Convention in DC 2Health News:Thought Technology to Present Software for Stress Control at the 2014 American Psychological Association Convention in DC 3Health News:Children's impulsive behaviour is related to their brain connectivity 2
... device that alerts women whether or not they have taken their ... ,The Remember Device developed by Lai Chiu Tang, a student ... to take her pill with a choice of four alerts - ... vibrate mode, reported online edition of BBC News. ,The ...
... will start a health insurance policy next month which will ... that fall under the Phase 1 category will be obliged ... will make the lowest paid the first to benefit from ... the General Authority for Health Services (GAHS) in Abu Dhabi. ...
... Angeles: Pfizer has indicated that recent clinical trials of inhaled ... is found to be useful in regulating blood sugar levels ... Exubera, is slated to be introduced into the United States ... it for use in adults with Type 1 or Type ...
... Mittal it was appropriate for Rahul Mahajan to be taken ... taken to Apollo hospital and not to AIIMS or Safdarjang ... of overdosing. //But medical experts say drug overdosed patients should ... get treated, the better are the chances of their survival. ...
... and the 2004 tsunami, was dealt another blow when ... cultural city, a prime tourist destination. // ... and vibrant arts and crafts scene is second only ... ,"We're suffering another setback," said Wulandari, a hotel receptionist ...
... always painstaking and reaps benefits only when done with full dedication. ... Schlegel in Georgetown. This has brought to the world the first ... was when on June 8, the Food and Drug Administration approved ... strains of HPV. ,In the doctor’s own words, "It's ...
Cached Medicine News:Health News:The myth about government hospitals 2Health News:Indonesian Tourism on Downward Trend After Java Quake 2
(Date:7/21/2014)... , July 21, 2014 /PRNewswire-iReach/ -- Nitrosolution.com, a website ... , will celebrate its first anniversary in August. The ... designed to enhance the body,s ability to produce nitric ... is made up of a variety of phytonutrients and ... been found to increase nitric oxide production ...
(Date:7/21/2014)... YORK , July 21, 2014  EHE International, ... exams with a nationwide physician network, today announced that ... Las Vegas, NV has been named an ... the Las Vegas region now ... help proactively maintain their health. "EHE ...
(Date:7/21/2014)... ALBANY, New York , July 21, 2014 /PRNewswire/ ... market report published by Transparency Market Research "E-Clinical Solution ... and Forecast, 2014 - 2020," the global microfluidic device ... and is expected to grow at a CAGR of ... value of USD 6,515.3 million in 2020. ...
Breaking Medicine Technology:Up and Coming Nitric Oxide Supplements Company Nitrosolution.com Celebrates its One Year Anniversary 2EHE International Certifies Dignity Health Medical Group Nevada, LLC as Its Newest Partner 2E-Clinical Solution Software Market is expected to reach USD 6,515.3 million in 2020: Transparency Market Research 2E-Clinical Solution Software Market is expected to reach USD 6,515.3 million in 2020: Transparency Market Research 3E-Clinical Solution Software Market is expected to reach USD 6,515.3 million in 2020: Transparency Market Research 4E-Clinical Solution Software Market is expected to reach USD 6,515.3 million in 2020: Transparency Market Research 5
... Monogram,Biosciences, Inc. (Nasdaq: MGRM ) announced ... Pfizer Inc,s (NYSE: PFE ) phase III ... CCR5-tropic,HIV-1, increased efficacy was shown as a result ... of the enhanced version of Monogram,s Trofile(TM),Assay., ...
... Oct. 26 Paratek Pharmaceuticals, Inc. today,announced positive ... PTK,0796, a first-in-class aminomethylcycline (AMC). The Phase 2 ... (IV) forms of PTK 0796 to,Zyvox(R) in the ... infections (cSSSIs). Paratek,s trial met its primary safety ...
Cached Medicine Technology:Data Reported at ICAAC Indicates Selzentry(TM) Phase III Treatment-Naive Trial Shows Increased Efficacy When Used With Enhanced Trofile(TM) Assay 2Data Reported at ICAAC Indicates Selzentry(TM) Phase III Treatment-Naive Trial Shows Increased Efficacy When Used With Enhanced Trofile(TM) Assay 3Data Reported at ICAAC Indicates Selzentry(TM) Phase III Treatment-Naive Trial Shows Increased Efficacy When Used With Enhanced Trofile(TM) Assay 4Data Reported at ICAAC Indicates Selzentry(TM) Phase III Treatment-Naive Trial Shows Increased Efficacy When Used With Enhanced Trofile(TM) Assay 5Data Reported at ICAAC Indicates Selzentry(TM) Phase III Treatment-Naive Trial Shows Increased Efficacy When Used With Enhanced Trofile(TM) Assay 6Paratek Reports Positive Phase 2 Clinical Data on its New Antibiotic PTK 0796 in Late Breaker Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy 2Paratek Reports Positive Phase 2 Clinical Data on its New Antibiotic PTK 0796 in Late Breaker Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy 3Paratek Reports Positive Phase 2 Clinical Data on its New Antibiotic PTK 0796 in Late Breaker Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: