Navigation Links
Neurological and executive function impairment associated with breast cancer

CHICAGO Women who survive breast cancer show significant neurological impairment, and outcomes appear to be significantly poorer for those treated with chemotherapy, according to a report in the November issue of the Archives of Neurology, one of the JAMA/Archives journals.

Breast cancer (BC) is one of the most common public health problems, with a worldwide estimated incidence of 39 per 100,000 individuals annually. Although primary BC has not been associated historically with neurological problems, a growing body of evidence suggests that patients are at increased risk for altered brain structure and function, according to background information in the article.

Shelli R. Kesler, Ph.D., and colleagues at Stanford University School of Medicine, Stanford, Calif., conducted an observational study to determine whether profiles of brain activation differ among BC survivors treated with or without chemotherapy, compared with healthy control women. The study included 25 women with BC who received chemotherapy, 19 women with BC who did not receive chemotherapy, and 18 healthy female controls, all matched for age and other demographic variables. The women were asked to perform various tasks, and the researchers used functional MRI to measure activation in several areas of the brain.

"Women with BC demonstrated significantly reduced activation in the left middle dorsolateral prefrontal cortex and premotor cortex compared with healthy controls," the authors report.

"The chemotherapy group also demonstrated significantly reduced left caudal lateral prefrontal cortex activation and increased perseverative errors and reduced processing speed compared with the other two groups," they write.

The study also found that the negative effects of chemotherapy on brain function may be exacerbated by such factors as increased age and lower educational level.

"This study provides further evidence that primary BC may cause measurable brain injury," the authors conclude. "Women treated with chemotherapy may show additional prefrontal deficits and have difficulty compensating for neurobiological changes such that they also show impaired executive function."


Contact: Michelle Brandt
JAMA and Archives Journals

Related medicine news :

1. Neurological disorder impacts brain cells differently
2. Harvard Medical School and EPFL launch program targeting neurological disabilities
3. Researcher tests drugs impact on neurological disease affecting women
4. Cedars-Sinai to hold first annual conference on stem cell therapies for neurological disorders
5. Neurological protein may hold the key to new treatments for depression
6. Elseviers BrainNavigator 3.0 reflects the next step in enhancing neurological research
7. NYU researchers identify new neurological deficit behind lazy eye
8. Scientists explain the neurological process for the recognition of letters and numbers
9. Team led by LA BioMed scientist develops novel approach to study neurological disorders
10. University Hospitals Neurological Institute earns Neuroscience Center of Excellence designation
11. University Hospitals Neurological Institute hosts international epilepsy colloquium
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... The rapid ... America. As people age, more care is needed, especially with Alzheimer’s, dementia and ... professionals are being overworked. The forgotten part of this equation: 80 percent of ...
(Date:11/27/2015)... ... November 27, 2015 , ... The print component of ... in Atlanta, Dallas, New York, Minneapolis, South Florida, with a circulation of approximately ... nationally, through a vast social media strategy and across a network of top ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... A simply ... Jones, is an interesting show that delves into an array of issues that are ... that could benefit from open dialogue, this show is changing the subjects consumers focus ...
(Date:11/27/2015)... ... , ... Dr. Thomas Dunlap and Dr. Patrick Coleman , ... Emergency Medicine at St., Joseph Health System’s Santa Rosa Memorial Hospital , co-hosted ... similar ways and require time-critical intervention to avoid large area heart damage and progressive ...
(Date:11/26/2015)... ... November 26, 2015 , ... CognisantMD and ... diagnostic imaging in the Waterloo region. Using the Ocean Platform, family physicians can ... from their electronic medical record (EMR) without the need for redundant patient entry ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... DUBLIN , Nov. 26, 2015 /PRNewswire/ ... announced the addition of the "2016 ... by Test, Country Volume and Sales Segment ... Emerging Opportunities" report to their offering. ... the addition of the "2016 Global ...
(Date:11/26/2015)... --> --> ... immunotherapy with Bremachlorin-photodynamic therapy for advanced cancer.   ... with Bremachlorin-photodynamic therapy for advanced cancer.   ... with Bremachlorin-photodynamic therapy for advanced cancer.   ... immunotherapy can be efficiently combined with photodynamic therapy (PDT) ...
(Date:11/26/2015)... FRANCISCO , November 26, 2015 ... billion by 2022, according to a new report by Grand ... Chronic Kidney Disease (CKD) which demands kidney transplantation is expected ... and cost effective substitute for organ transplantation. --> ... billion by 2022, according to a new report by Grand ...
Breaking Medicine Technology: