Navigation Links
Neurological and executive function impairment associated with breast cancer
Date:11/14/2011

CHICAGO Women who survive breast cancer show significant neurological impairment, and outcomes appear to be significantly poorer for those treated with chemotherapy, according to a report in the November issue of the Archives of Neurology, one of the JAMA/Archives journals.

Breast cancer (BC) is one of the most common public health problems, with a worldwide estimated incidence of 39 per 100,000 individuals annually. Although primary BC has not been associated historically with neurological problems, a growing body of evidence suggests that patients are at increased risk for altered brain structure and function, according to background information in the article.

Shelli R. Kesler, Ph.D., and colleagues at Stanford University School of Medicine, Stanford, Calif., conducted an observational study to determine whether profiles of brain activation differ among BC survivors treated with or without chemotherapy, compared with healthy control women. The study included 25 women with BC who received chemotherapy, 19 women with BC who did not receive chemotherapy, and 18 healthy female controls, all matched for age and other demographic variables. The women were asked to perform various tasks, and the researchers used functional MRI to measure activation in several areas of the brain.

"Women with BC demonstrated significantly reduced activation in the left middle dorsolateral prefrontal cortex and premotor cortex compared with healthy controls," the authors report.

"The chemotherapy group also demonstrated significantly reduced left caudal lateral prefrontal cortex activation and increased perseverative errors and reduced processing speed compared with the other two groups," they write.

The study also found that the negative effects of chemotherapy on brain function may be exacerbated by such factors as increased age and lower educational level.

"This study provides further evidence that primary BC may cause measurable brain injury," the authors conclude. "Women treated with chemotherapy may show additional prefrontal deficits and have difficulty compensating for neurobiological changes such that they also show impaired executive function."


'/>"/>

Contact: Michelle Brandt
mbrandt@stanford.edu
650-723-0272
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Neurological disorder impacts brain cells differently
2. Harvard Medical School and EPFL launch program targeting neurological disabilities
3. Researcher tests drugs impact on neurological disease affecting women
4. Cedars-Sinai to hold first annual conference on stem cell therapies for neurological disorders
5. Neurological protein may hold the key to new treatments for depression
6. Elseviers BrainNavigator 3.0 reflects the next step in enhancing neurological research
7. NYU researchers identify new neurological deficit behind lazy eye
8. Scientists explain the neurological process for the recognition of letters and numbers
9. Team led by LA BioMed scientist develops novel approach to study neurological disorders
10. University Hospitals Neurological Institute earns Neuroscience Center of Excellence designation
11. University Hospitals Neurological Institute hosts international epilepsy colloquium
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... ... July 21, 2017 , ... The Visiting ... the C. R. Bard Foundation, Inc. to support the music therapy ... service available through the nonprofit home care agency. Using evidence-based methods, professionally trained ...
(Date:7/21/2017)... ... July 21, 2017 , ... Sharon Kleyne is ... product of her research center at Bio-Logic Aqua Research® Water Life Science®, has ... greatest number of sufferers of blindness. “We think that Nature’s Tears® EyeMist® will ...
(Date:7/21/2017)... , ... July 21, 2017 , ... ... cruciate ligament (ACL) offer patients improved quality of life five years after injury, ... Medicine’s Annual Meeting in Toronto, Ontario, Canada. The study followed patients for ...
(Date:7/20/2017)... ... July 20, 2017 , ... ChenMed , a ... joined JenCare Senior Medical Center as Richmond Chief Medical Officer. Dr. ... Medicine, and Associate Chief Medical Officer of Ambulatory Services for the UVA Health System, ...
(Date:7/20/2017)... ... July 20, 2017 , ... ... in Houston, is pleased to announce their expansion to the Midwest with the ... directors Alysse Hollis and Ronald Bell, and of counsels, John Peck and Robert ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... -- Did you know that PhRMA member companies invested $65.5 billion ... on brand medicines, generics and the supply chain account for 14 ... half of this (7 percent)? Or that the United ... capital investments in high-growth biopharmaceutical startups? ... The biopharmaceutical industry ...
(Date:7/15/2017)... 15, 2017 Enterin Inc., a Philadelphia ... disease (PD), today announced the completion of a $12.7 million ... Ventures III, as well as the participation of existing investors. ... to have the support of New Ventures III and our ... validation of the potential of our platform technology to transform ...
(Date:7/13/2017)... -- RK Logistics Group, Inc. was awarded California ... Fremont, CA headquarters facility where it provides ... San Jose for hi-tech, pharmaceutical and biomedical ... with its Fremont Innovation District, is excited to strategically partner ... to the hundreds of biotech, pharma and biomed companies throughout ...
Breaking Medicine Technology: