Navigation Links
Neuroinflammation may be behind general-anesthesia-associated learning disabilities
Date:1/24/2013

showed elevated levels of several markers of inflammation.

Mice that received only one dose of sevoflurane showed neither neuroinflammation nor cognitive impairment compared with the control group. No adverse effects were seen in either adult mice that received three doses of sevoflurane or in young mice that received three doses of desflurane, another commonly used anesthetic. Two strategies preanesthesia treatment with an anti-inflammatory drug and placing the young animals in an enriched environment cages that featured ladders, wheels and mazes each appeared to reduce the negative effects of three doses of sevoflurane.

The second study co-led by Hui Zheng, MD, PhD, of MGH Anesthesia and Dong exposed a group of pregnant female mice to a single two-hour dose of sevoflurane when two-thirds through the gestation period. In assessments conducted 30 days after the females gave birth, offspring of those that received sevoflurane showed evidence of impaired learning and memory, compared with a control group. In addition, analysis of the brain tissue of fetal mice, taken right after the pregnant mice received the sevoflurane dose, and of month-old offspring showed elevated inflammatory markers and other signs of neurotoxicity including a reduction in the number of brain synapses compared with control offspring. As in the first study, placing a group of anesthesia-exposed pregnant mice and then their offspring into an enriched environment appeared to reduce both the neuroinflammatory and behavioral effects on the offspring of prenatal exposure to sevoflurane.

"Six million children undergo surgery each year in the U.S., and the possibility that anesthesia and surgery could increase the risk for learning disabilities is a major concern for both the medical community and the general public," says Xie, an associate professor of Anesthesia at Harvard Medical School. "We hope our findings will promote more research into anesthesia neuro
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Gene Behind Psoriasis Identified, Researchers Say
2. Researchers gain better understanding of mechanism behind tau spreading in the brain
3. New global report says US lags behind 130 other nations in preterm birth rate
4. New American Chemical Society video: Behind the scenes tour of an electronic nose lab
5. Fruit flies reveal mechanism behind ALS-like disease
6. The Tennessee Car Accident Lawyers at Michael D. Ponce & Associates Alert Public of CDC Survey Revealing Majority of High School Seniors Admitting to Texting Behind Wheel
7. Superpowered Bacteria May Lurk Behind Sinus Infections
8. Scientists Focus on Factors Behind Asthma Attacks
9. Lab Contamination Behind Debunked Link Between Virus, Prostate Cancer
10. Greenish-Black Contaminant in Vials of Steroid Behind Meningitis Outbreak: FDA
11. Unlocking the genetic mysteries behind stillbirth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2014)... harmful effects in children, codeine continues to be prescribed ... UCSF Benioff Children,s Hospital San Francisco. , As reported ... include changing provider prescription behaviors to promote the use ... hydrocodone. , "Despite strong evidence against the use of ... to large numbers of them each year," said Sunitha ...
(Date:4/18/2014)... in The Gerontologist reports that ... with a decrease in anxiety about death and increases ... their lives. In particular, listening to gospel music is ... an increase in sense of control. , These associations ... and individuals of both low- and high-socioeconomic status. , ...
(Date:4/18/2014)... a brain-related discovery that could revolutionize doctors, perception ... opens up the possibility that environmental and/or genetic ... activity that the researchers have identified as helping ... Neuroscience has just published a paper about ... of psychology and his doctoral student John Gaspar, ...
(Date:4/17/2014)... chronic inflammation in non-cancerous prostate tissue may have nearly ... those with no inflammation, according to results of a ... Kimmel Cancer Center. , The link between persistent inflammation ... high-grade prostate cancer those with a Gleason score ... the most aggressive and rapidly growing prostate cancers. , ...
(Date:4/17/2014)... Experimental Biology and Medicine a multidisciplinary research ... Kenis in the Institute of Genomic Biology (IGB) ... Urbana-Champaign describe their recent work on subcellular redox ... cell functions including energy metabolism, signaling, and transcriptional ... normal cellular behavior, redox status has been recognized ...
Breaking Medicine News(10 mins):Health News:UCSF study finds codeine often prescribed to children, despite available alternatives 2Health News:Religious music brings benefit to seniors' mental health 2Health News:Scientists discover brain's anti-distraction system 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2
... , , , MANHATTAN, Kan., ... work of a K-State researcher are making headway in the effort ... Juergen Richt is a Regents Distinguished Professor at K-State,s College of ... work at K-State and with outside collaborators is revealing the characteristics ...
... Experts urge parents to get their kids, eyes checked regularly ... percent of kids aged 12 to 17 have trouble seeing ... the nearly 1,500 children in the survey, more than 25 ... though 45 percent of them wore some type of prescription ...
... , CHESTNUT HILL, Mass., Aug. 3 SkinCare ... live Artefill patient demonstration at the American Academy of Dermatology Summer ... collagen filler for the correction of smile lines and was one ... 31st. , , "Over the past several years ...
... , ALLEGAN, Mich., Aug. 3 Perrigo Company (Nasdaq: ... Pharmaceutical Industries Ltd. (Nasdaq: TEVA ) (previously Barr Laboratories ... Administration to market Triamcinolone Acetonide Nasal Spray containing a paragraph IV ... complete ANDA with a Paragraph IV certification for NASACORT AQ. The ...
... equipment alone is responsible for an increased number of ... to a study performed at San Luis Diagnostic Center ... that there was a significant increase in the number ... to digital mammography. The number of cancers detected prior ...
... in French . Heavy drinkers of ... cancer than the population at large, says a group of ... in the highest consumption category increased their risk of developing ... cancer by 50%. In all, the researchers found ...
Cached Medicine News:Health News:K-State Researcher, Collaborators Study Virulence of Pandemic H1N1 Virus; Work at K-State Would Protect Pig Industry If the Virus Jumps to Swine Populations 2Health News:Leading Boston Dermatologist Performs Live Artefill Patient Demonstration at American Academy of Dermatology Summer Meeting 2Health News:Perrigo Announces FDA Approval for Generic Version of NASACORT(R) AQ 2Health News:Perrigo Announces FDA Approval for Generic Version of NASACORT(R) AQ 3Health News:Heavy drinkers face significantly increased cancer risk 2
(Date:1/15/2014)... The Cadence Fitness & Health Center has been certified ... Association, a non-profit organization assisting medically integrated health and ... Fitness & Health Center is the only certified fitness ... Chicagoland area. "The certification means the Cadence ...
(Date:1/15/2014)... , Jan. 15, 2014 Reportlinker.com announces ... available in its catalogue: ... Forecast and Market Analysis to 2022 ... Atopic Dermatitis - India Drug Forecast and ...
(Date:1/15/2014)... NEW YORK , Jan. 15, ... new market research report is available ... Global Markets and Technologies for ... on Routes of Administration ...
Breaking Medicine Technology:Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 2PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 4PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16
... PHOENIX, Sept. 4 Zila, Inc.,s (Nasdaq: ZILA ... of,abnormalities which can lead to oral cancer, has been ... of Cetuximab (ERBITUX(R)), a,leading cancer therapeutic for head and ... and distributed by Bristol-Meyers Squibb (NYSE:,BMY). The NIH ...
... Meets Primary and All Secondary Endpoints, San ... NGSX ), a biopharmaceutical company focused on developing ... from,its second pivotal study of NGX-4010, the Company,s ... -- in patients with postherpetic,neuralgia (PHN). The study, ...
Cached Medicine Technology:Zila Inc. Product Selected to Identify Pre-Cancer in Study of Leading Cancer Treatment Chemotherapeutic - ERBITUX 2Zila Inc. Product Selected to Identify Pre-Cancer in Study of Leading Cancer Treatment Chemotherapeutic - ERBITUX 3NeurogesX Announces Positive Results from Second Phase 3 Clinical Trial in Postherpetic Neuralgia 2NeurogesX Announces Positive Results from Second Phase 3 Clinical Trial in Postherpetic Neuralgia 3NeurogesX Announces Positive Results from Second Phase 3 Clinical Trial in Postherpetic Neuralgia 4NeurogesX Announces Positive Results from Second Phase 3 Clinical Trial in Postherpetic Neuralgia 5NeurogesX Announces Positive Results from Second Phase 3 Clinical Trial in Postherpetic Neuralgia 6NeurogesX Announces Positive Results from Second Phase 3 Clinical Trial in Postherpetic Neuralgia 7
This fume hood features a one-piece shell molded of polyethylene with a clear acrylic panel that slides on inside tracks. It can be set in an open, closed or intermediate position....
These handy dispensers save space and organize gloves in labs and next to hand washers. Clear acrylic. Many other sizes and custom configurations available....
... Sledge Microtome is ideal for sectioning of specimens ... Specimen rise is automatic and accurate with ... in increments of 2 microns. Will accommodate ... Vibratomes Freezing Stages , ...
... The Professional Gold Package ... your laboratory. The package includes ... and automated system, starter package ... v-block adapter, specimen mounts 1/2" ...
Medicine Products: