Navigation Links
Neuroimaging may shed light on how Alzheimer's disease develops
Date:1/11/2010

Amsterdam, January 11, 2010 Current Alzheimer's disease (AD) research indicates that accumulation of amyloid-beta (Aβ) protein plaques in the brain is central to the development of AD. Unfortunately, presence of these plaques is typically confirmed only at autopsy. In a special issue of the journal Behavioural Neurology, researchers review the evidence that Positron Emission Tomography (PET) can image these plaques during life. This exciting new technique provides researchers with an opportunity to test the amyloid hypothesis as it occurs in living patients.

In a review article with over 100 references, Dr. Gil Rabinovici and Dr. William Jagust from the University of California, San Francisco and Berkeley, summarize the results of experiments from their laboratories and others using the Aβ tracer Pittsburgh Compound-B (PIB). This compound binds to Aβ protein and allows the mapping of plaques in the brains of AD and non-AD volunteer subjects.

They report that PIB-PET can detect Aβ deposits in a significant proportion of cognitively normal older subjects and that these deposits are associated with brain atrophy even in the absence of cognitive symptoms. By the time patients develop mild cognitive impairment (MCI) amyloid load in the brain appears to have reached a plateau. As patients progress to dementia, neurodegeneration and cognitive decline proceed independently of further amyloid accumulation.

The authors interpret these results as consistent with a model in which amyloid deposition plays a critical early role on the path to AD, beginning years before onset of symptoms and triggering a series of events which ultimately leads to cognitive decline and dementia.

While the use of PIB-PET is currently limited to research centers because of the compound's very short radioactive half-life (20 minutes), new amyloid imaging agents with longer half-lives are under development for more widespread use. Amyloid imaging is already playing an important role in the development of amyloid-based therapies for AD, and Dr. Rabinovici and Dr. Jagust speculate that in the future amyloid imaging will assist clinicians in identifying patients with mild or atypical symptoms who may be candidates for anti-amyloid treatments.

Writing in the article, the authors state, "PIB-PET has provided us with our first in vivo glance at the dynamic relationship between amyloid deposition, clinical symptoms, and structural and functional changes in the brain in the continuum between normal aging and ADIn the future, Aβ imaging will likely supplement clinical evaluation in selecting patients for anti-amyloid therapies both during drug development and in the clinic."


'/>"/>

Contact: Esther Mateike
e.mateike@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Related medicine news :

1. Neuroimaging provides insights into new treatment options for Alzheimers disease
2. Neuroimaging suggests that truthfulness requires no act of will for honest people
3. Alzheimers Disease Neuroimaging Initiative announces completion of genome-wide analysis
4. Michael J. Fox Foundation Awards $1.9 Million for Development of Non-Invasive Neuroimaging Techniques in Living Brain
5. Researchers use neuroimaging to study ESP
6. New neuroimaging study identifies brain signature for cigarette cravings
7. Study sheds light on role of stem cells in childrens brain tumor
8. Study explains why light worsens migraine headaches
9. Why Light Hurts During Migraines
10. HRh Princess Haya Highlights Need for Medical Research
11. Make Your 2010 Resolution and Chill Out with Crystal Light Frozen Treats
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2017)... ... 2017 , ... Today, June 27th is PTSD Awareness Day. Over half a ... receive adequate care due to lack of effective treatments, fear of stigma or insufficient ... left untreated, veterans are at an increased risk for self-destructive behavior, including alcohol/drug abuse, ...
(Date:6/27/2017)... ... June 27, 2017 , ... Children’s National Health System ... rankings, with its Neonatology program ranking #1 out of more than 1500 neonatal ... to the coveted Honor Roll, a distinction given to the top performing children’s hospitals ...
(Date:6/26/2017)... ... June 26, 2017 , ... Dr. Martin Bastuba, MD, ... collaboration with the Fertility Center of California, is pleased to announce the addition ... aspiration) and TESA (percutaneous testicular sperm extraction). These minimally invasive treatments are primarily ...
(Date:6/26/2017)... ... June 26, 2017 , ... A ... revolutionizing the way women look and feel about themselves and their sexual encounters. ... sexual dysfunction and urinary leakage head on with a ground breaking medical technique ...
(Date:6/26/2017)... ... June 26, 2017 , ... KICKICO , a protocol built ... pledges to solve many catastrophic issues within funding campaigns. KICKICO developers are testing the ... of crowdfunding - the raising of funds through the power of many - has ...
Breaking Medicine News(10 mins):
(Date:6/16/2017)... 50 years ago today, the Monterey Pop Festival opened its ... San Francisco "Summer of Love."  To celebrate the anniversary, Northern ... strategic market research portals that it will begin delivering to ... Light,s "Summer of Love (For Our Customers)."  ... Northern ...
(Date:6/14/2017)... , June 14, 2017 The Bio ... City of Fremont and the ... the bio-pharma industry in California ... enabling executive networking, and fostering workforce development. The primary ... and growth of start-ups, as well as small and ...
(Date:6/13/2017)... WARSAW, Ind. , June 13, 2017 Zimmer ... in musculoskeletal healthcare, today announced that the U.S. Food and ... Letter dated June 3, 2015 relating to its ... "The successful clearance of ... China manufacturing facility is a measure of the ...
Breaking Medicine Technology: