Navigation Links
Neuroimaging may shed light on how Alzheimer's disease develops
Date:1/11/2010

Amsterdam, January 11, 2010 Current Alzheimer's disease (AD) research indicates that accumulation of amyloid-beta (Aβ) protein plaques in the brain is central to the development of AD. Unfortunately, presence of these plaques is typically confirmed only at autopsy. In a special issue of the journal Behavioural Neurology, researchers review the evidence that Positron Emission Tomography (PET) can image these plaques during life. This exciting new technique provides researchers with an opportunity to test the amyloid hypothesis as it occurs in living patients.

In a review article with over 100 references, Dr. Gil Rabinovici and Dr. William Jagust from the University of California, San Francisco and Berkeley, summarize the results of experiments from their laboratories and others using the Aβ tracer Pittsburgh Compound-B (PIB). This compound binds to Aβ protein and allows the mapping of plaques in the brains of AD and non-AD volunteer subjects.

They report that PIB-PET can detect Aβ deposits in a significant proportion of cognitively normal older subjects and that these deposits are associated with brain atrophy even in the absence of cognitive symptoms. By the time patients develop mild cognitive impairment (MCI) amyloid load in the brain appears to have reached a plateau. As patients progress to dementia, neurodegeneration and cognitive decline proceed independently of further amyloid accumulation.

The authors interpret these results as consistent with a model in which amyloid deposition plays a critical early role on the path to AD, beginning years before onset of symptoms and triggering a series of events which ultimately leads to cognitive decline and dementia.

While the use of PIB-PET is currently limited to research centers because of the compound's very short radioactive half-life (20 minutes), new amyloid imaging agents with longer half-lives are under development for more widespread use.
'/>"/>

Contact: Esther Mateike
e.mateike@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Neuroimaging provides insights into new treatment options for Alzheimers disease
2. Neuroimaging suggests that truthfulness requires no act of will for honest people
3. Alzheimers Disease Neuroimaging Initiative announces completion of genome-wide analysis
4. Michael J. Fox Foundation Awards $1.9 Million for Development of Non-Invasive Neuroimaging Techniques in Living Brain
5. Researchers use neuroimaging to study ESP
6. New neuroimaging study identifies brain signature for cigarette cravings
7. Study sheds light on role of stem cells in childrens brain tumor
8. Study explains why light worsens migraine headaches
9. Why Light Hurts During Migraines
10. HRh Princess Haya Highlights Need for Medical Research
11. Make Your 2010 Resolution and Chill Out with Crystal Light Frozen Treats
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... 1, 2014Lesbian, gay, bisexual, and transgender individuals who want ... as some of their heterosexual and cisgendered peers, such ... additional physiological and legal challenges to become parents. ... assisted reproduction options is presented in the article " ... published in LGBT Health , a ...
(Date:8/1/2014)... London, UK (PRWEB) August 01, 2014 ... Scientific Publications research reports have been added to ... 2014-2020, Formulations, Active Pharmaceutical Ingredients (APIs), Contract Research ... . The key pharma industry drivers include, among ... awareness of personal hygiene. In 2015, the pharma ...
(Date:8/1/2014)... -- Patients with the progressive, deadly respiratory ailment known ... weapon to battle the disease, the U.S. Food and ... a new treatment, an inhaled spray called Striverdi Respimat ... COPD, which is often linked to smoking, involves multiple ... Patients with COPD may experience a number of ...
(Date:8/1/2014)... The North America Endpoint Security Market report defines ... America with analysis and forecast of revenue. This market ... 2014 to $4.77 billion by 2019, at a CAGR ... the TOC of the North America Endpoint Security Market ... provided. It also provides a glimpse of the segmentation ...
(Date:8/1/2014)... 2014 (BRONX, NY) Scientists at Albert ... found that bacteria that aid in digestion help keep ... the journal Immunity , could yield new therapies ... of other disorders. , The research involved the intestinal ... of these microorganisms in promoting or preventing disease is ...
Breaking Medicine News(10 mins):Health News:Advances in assisted reproduction create more options and new legal issues for LGBT couples 2Health News:In-demand Markets Research Reports by Kelly Scientific Publications Now Available at MarketPublishers.com 2Health News:In-demand Markets Research Reports by Kelly Scientific Publications Now Available at MarketPublishers.com 3Health News:FDA Approves New Treatment for People With COPD 2Health News:North America End-Point Security Market is Expected to Reach $4 billion in 2019 - New Report by MicroMarket Monitor 2Health News:North America End-Point Security Market is Expected to Reach $4 billion in 2019 - New Report by MicroMarket Monitor 3Health News:North America End-Point Security Market is Expected to Reach $4 billion in 2019 - New Report by MicroMarket Monitor 4Health News:'Normal' bacteria vital for keeping intestinal lining intact 2
... border with hard-hit China. ,The first confirmed case of SARS ... river, which forms the frontier with China, came as Chinese ... could contain the disease.,Hu told students in Moscow, at the ... measures to stop the spread of the deadly virus and ...
... key step towards ensuring rapid action against future ... international public health. A resolution adopted today confirms ... to verify disease outbreaks from all available official ... the severity of an outbreak through on-the-spot investigations ...
... Alzheimer's affects about 12 million people worldwide. Lithium may ... an enzyme called GSK-3 that facilitates the modification of ... GSK-3 as a target could help in developing other ... ,Another advantage to lithium is that it does not ...
... the smallest number of new cases since the Beijing ... the SARS epidemic last month. Two additional deaths also ... China's death toll from Severe Acute Respiratory Syndrome to ... at 5,316. ,Hong Kong reported just one new ...
... Health Organization has lifted its SARS-related travel warnings for ... breakthrough in the origin of the virus emerged. It ... praised national health authorities for controlling the outbreak in ... the lifting of the warning, praising the efforts of ...
... said that mammograms remain the most ,important tool in ... 40 years of age ,receive mammograms ,annually. Researchers say ... ,of cancers. They also said ,that self-examination did not ... that have grown for two years, while self-exams detect ...
Cached Medicine News:Health News:Lithium May help in Alzheimer's Disease 2
(Date:7/31/2014)... 2014 Nektar Therapeutics (Nasdaq: NKTR ) ... June 30, 2014. Cash and investments in ... compared to $309.1 million at March 31, 2014."The second half ... we look forward to significant milestones for a number of ... Chief Executive Officer of Nektar. "The first of these is ...
(Date:7/31/2014)...  UBM Medica US announces that Cancer ... presents exclusive slide shows dealing with communication in the ... care. Cancer Network, the online ... blogs, and podcasts about the latest clinical findings. Among ... , End-of-life care is challenging for even the ...
(Date:7/31/2014)... , July 31, 2014  Decision Resources Group ... market intelligence product Marketrack to now include ChinaTrack; the ... device landscape in an interactive dashboard providing detailed brand-level ... volumes at a hospital level. Other key ... Updated data feed: In addition to end-user surveys of ...
Breaking Medicine Technology:Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 2Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 3Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 4Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 5Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 6Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 7Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 8Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 9Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 10Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 11Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 12Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 13Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 14Cancer Network Highlights Methods Oncologists Can Use to Improve Communication 2Cancer Network Highlights Methods Oncologists Can Use to Improve Communication 3Decision Resources Group Announces First Medical Device Account Targeting Tool in China 2
... Feb. 8, 2011 Pharmaceutical Care Management Association (PCMA) ... today on Florida Governor Rick Scott,s Medicaid savings proposal: ... reduce wasteful spending in Medicaid, which is a big ... its old-school ,fee-for-service, approach, Florida Medicaid pays drugstores much ...
... (Nasdaq: DYNT ) plans to release financial results ... during the morning of Monday, February 14, 2011.   ... that day at 1:30 p.m. ET to discuss its results ... 926-7431 and use access code: 5687000. Dynatronics manufactures, ...
Cached Medicine Technology:
The Hilan pneumatic high speed drill system consists of a pneumatic motor and drill with various cutting attachments....
The XK-95 High Speed Drill System sets new technological and performance standards for surgical drill systems....
Circular Spine Retractor System for microsurgical interventions in the lumbar and cervical spine region. The system has been approved in over 120 cases....
... The Ruggles Retractor System, a ... and the versatility of two systems ... hands from the surgical site during ... accurate retractor insertion. The retractor body ...
Medicine Products: