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NeurogesX Reports Fourth Quarter and Year-End 2007 Financial Results
Date:3/26/2008

ined in the Act. Examples of such statements include, but are not limited to, statements regarding regulatory submissions, including the expected timing of such submissions, and the potential scope of indications included in NeurogesX' expected NDA filing with the FDA or covered by the potential MAA approval; and the expected benefits of NeurogesX' potential products, including its lead product candidate NGX-4010. Such statements are based on management's current expectations, but actual results may differ materially due to various risks and uncertainties, including, but not limited to, NeurogesX' product candidates may fail to demonstrate adequate therapeutic efficacy or may have unexpected adverse side effects; positive results in clinical trials may not be sufficient to obtain FDA or European regulatory approval; prior Phase 3 studies that have not met their endpoints may impact timing of, or prevent, regulatory approval; physician or patient reluctance to use NGX-4010, or the inability of physicians to obtain sufficient reimbursement for such procedures may limit product utilization if approved; maintaining adequate patent or trade secret protection without violating the intellectual property rights of others; and other difficulties or delays in clinical development, obtaining regulatory approval, market acceptance and commercialization of NGX-4010. For further information regarding these and other risks related to NeurogesX' business, investors should consult NeurogesX' filings with the Securities and Exchange Commission.

NeurogesX, Inc. The Ruth Group

Stephen Ghiglieri Stephanie Carrington / Elizabeth

Chief Financial Officer Scott (investors)

(650) 358-3310 (646) 536-7017 / 7014

scarrington@theruthgroup.com

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SOURCE NeurogesX, Inc.
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