Navigation Links
Neurogenesis in the adult brain: The association with stress and depression
Date:8/31/2008

an not only stimulate neurogenesis, but also exert similar stimulatory effects on gliogenesis. Moreover, animal studies have recently shown that chronic stress inhibits cell proliferation not only in the hippocampus but also in the prefrontal cortex, and that this inhibitory effect can be counteracted by antidepressant treatment (Czh et al., 2007). The significance of these observations is strengthened by in vivo neuroimaging studies in patients with mood disorders that consistently point to the involvement of prefrontal brain sites in the pathophysiology of the disease. These imaging findings are further supported by reports on human post-mortem tissues revealing that the number of glial cells in the prefrontal cortex is adversely affected in patients with mood disorders.

Experiments show that stress and depression inhibit the growth of new nerve cells as well as glial support cells, and that this inhibitory effect can be counteracted by antidepressive therapy.

Clinical implications

  • Within the last two decades, the understanding of the mature brain has changed: Neuronal and glial cell networks in the brain are far from being fixed and immutable a multitude of factors such as environmental stimulation, learning, growth factors, glucocorticoids, sexual hormones, stress, aging, and several neurotransmitters regulate the generation of new neurons. Antidepressants stimulate the growth of neurons and glial cells again so the brain changes that occur as a consequence of stress and depression are generally reversible.

  • Today it is widely believed that neurogenesis in the adult brain is restricted to selected brain regions such as zones of the hippocampus and the lateral brain ventricles. However, a growing number of recent studies describe the generation of new neurons also in the adult neocortex. Although small in both number and size, these new cells could have a significant impact on neocortical function.


    '/>"/>

Contact: Sonja Mak
s.mak@update.europe.at
43-140-557-340
European College of Neuropsychopharmacology
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Neurogenesis in the adult brain: The association with stress and depression
2. Younger Adults in Illinois Aided by Expansion of Health Care Coverage
3. 79 million US adults have medical bill problems or are paying off medical debt
4. Older Adults Reluctant to Question Surgical Treatment
5. Study shows that older adult caregivers of people with dementia have worse sleep than noncaregivers
6. Poor Coordination in Childhood Tied to Adult Obesity
7. State Support for Programs to Decrease Tobacco Use Among Teens and Adults on the Decline According to Trend Report Released Today
8. Half of U.S. Adults Lack 20/20 Vision
9. When it comes to abstinence teens, adults arent speaking the same language
10. KLRI Receives Grant From NIH to Study Stress Resilience in Older Adults
11. Risk of unintentional injury death is high for young children living with unrelated adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... 2015 , ... Last week, the Mesothelioma Applied Research Foundation ... accessed by visiting http://www.curemeso.org/store . , “Our new store features a variety ... a product is purchased, the Meso Foundation receives a $5.00 donation,” said Beth ...
(Date:7/31/2015)... ... ... There’s no better way to enjoy the summer weather than by being outside ... making July the most appropriate to be National Hot Dog Month. King Kullen honors ... next cookout different than the ones in the past. Celebrate National Hot Dog Month ...
(Date:7/31/2015)... View, CA (PRWEB) , ... July 31, 2015 , ... ... for the athletes, judges, media, and VIPs at the 2015 Vans US Open of ... organic coconut water that can claim “no added sugar” on the market, is a ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... According to the article published ... of the Pasadena courthouse was contained and extinguished by the city’s fire department before it ... the building at the time of the fire, and it was a fire alarm system ...
(Date:7/31/2015)... York, New York (PRWEB) , ... ... ... renowned trial attorney Jason T. Brown’s live lecture on pharmaceutical negligence is ... July 28th, 2015 was well received with a 94% approval rating from ...
Breaking Medicine News(10 mins):Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3Health News:Coco Libre Brings Eco-conscious Hydration to Vans US Open of Surfing 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 3Health News:Re-Broadcast of Nationally Renowned Trial Attorney Jason T. Brown's Lecture on Pharmaceutical Negligence Now Available 2
... March 2 "President Obama,s appointment of Governor Kathleen ... is yet another clear signal that this is the ... a reality.Health care reform is crucial to fixing the ... Health and Human Services, we can be sure it ...
... donors to respond PHILADELPHIA, March 2 Today,s ... area. Many area blood drives were cancelled ... could not honor their appointments, resulting in a ... Cross, Penn-Jersey Region scheduled blood donations for the ...
... for Ultra-High Performance Liquid Chromatography (UHPLC) Applications; Company ... Mass., March 2 ESA Biosciences, Inc., a ... systems that improve results for pharmaceutical development and ... launch a new, ultra-high-performance version of its award-winning ...
... EVANSTON, Ill. --- Optical technology developed by a Northwestern ... be effective in detecting the presence of pancreatic cancer ... to clinical trial results published in the journal ... which researchers hope could help raise the extremely low ...
... researchers report that a naturally occurring compound found in ... respiratory inflammation that causes conditions like asthma, allergic rhinitis ... Published in the March edition of the journal ... chemical in broccoli, triggers an increase of antioxidant enzymes ...
... meets East as faculty, students and alumni from University ... journey to share their knowledge with peers on the ... taking place March 27 through April 14, includes a ... faculty member and editor-in-chief of University of the Rockies ...
Cached Medicine News:Health News:Kathleen Sebelius Ready to Lead Healthcare Reform in 2009 2Health News:Local Blood Donations Impacted by Today's Snow Storm 2Health News:ESA to Launch Corona(R) ultra(TM) at Pittcon 2009: Booth #1080 2Health News:ESA to Launch Corona(R) ultra(TM) at Pittcon 2009: Booth #1080 3Health News:ESA to Launch Corona(R) ultra(TM) at Pittcon 2009: Booth #1080 4Health News:ESA to Launch Corona(R) ultra(TM) at Pittcon 2009: Booth #1080 5Health News:Optical techniques show continued promise in detecting pancreatic cancer 2Health News:Optical techniques show continued promise in detecting pancreatic cancer 3Health News:Optical techniques show continued promise in detecting pancreatic cancer 4Health News:Broccoli may help protect against respiratory conditions like asthma 2Health News:University of the Rockies Faculty and Students Travel to China to Share Western Philosophy 2Health News:University of the Rockies Faculty and Students Travel to China to Share Western Philosophy 3
(Date:7/31/2015)... PORTLAND, Ore., July 31, 2015  Semler Scientific, Inc. ... and testing services to healthcare insurers and physician groups, ... June 30, 2015. "In the second ... over year revenue growth of 54%, quarter over quarter ... of the installed base of FloChec® units of 18%," ...
(Date:7/31/2015)...  Xencor, Inc. (NASDAQ: XNCR ), a clinical-stage ... of autoimmune diseases, asthma and allergic diseases, and cancer, ... to its board of directors. ... is a tremendous asset to our board," said ... of Xencor. "Xencor faces a range of opportunities for ...
(Date:7/31/2015)... India , July 31, 2015 ... CRM solutions for video, data and cloud computing ... with a leading pharma giant for Internet of ... different IoT applications offered on subscription model. ... Pharma giant is striving for business innovations ...
Breaking Medicine Technology:Semler Reports Second Quarter 2015 Financial Results 2Semler Reports Second Quarter 2015 Financial Results 3Semler Reports Second Quarter 2015 Financial Results 4Semler Reports Second Quarter 2015 Financial Results 5Semler Reports Second Quarter 2015 Financial Results 6Xencor Appoints Yujiro S. Hata to Board of Directors 2Xencor Appoints Yujiro S. Hata to Board of Directors 3Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2
... 4, 2010 Poniard Pharmaceuticals, Inc. (Nasdaq: ... therapies, today announced that it has been awarded $244,479 ... Qualifying Therapeutic Discovery Project (QTDP) program established under Section ... use the grant to advance the development of its ...
... Nov. 4, 2010 Eli Lilly and Company (NYSE: ... Officer John Lechleiter Ph.D. today presented an $11.6 million ... contributions of Lilly,s U.S. employees and retirees and a ... were raised for the Central Indiana chapter and other ...
Cached Medicine Technology:Poniard Pharmaceuticals Awarded $244,479 Grant Under Qualifying Therapeutic Discovery Project Program 2Poniard Pharmaceuticals Awarded $244,479 Grant Under Qualifying Therapeutic Discovery Project Program 3Lilly Surpasses United Way 2010 Campaign Goal 2
... for general applications and are equipped with our ... i.e. rigid endoscopes, range between 1 mm and ... to a 120 retrospection, and image angles ranging ... Endoscopes with working lengths of 1.5 meters and ...
Preclude Dura Substitute is the only non-biological membrane designed to "seal" around suture holes. 0.3 mm as nominal thickness....
... More than a patch, Duragen is ... dura mater. Duragen handles and conforms ... an innovative collagen matrix for dural ... repair of dural defects. Fully resorbed ...
Aaron 2250 is a multipurpose electrosurgical generator with monoploar and bi-polar functions....
Medicine Products: