Navigation Links
Neurocrine Biosciences Reports Fourth Quarter and Year-End 2008 Results
Date:2/3/2009

icant differences were observed in the key efficacy endpoints between 876008 and placebo.

GSK has advanced a novel lead CRF1 receptor antagonist compound, 561679, into a Phase II trial in patients with major depressive disorder. Enrollment of approximately 150 subjects is anticipated in this 6-week randomized, double-blind, placebo-controlled trial.

In addition to the two compounds listed above, GSK has also successfully completed a Phase I single dose-escalating clinical trial with a third CRF1 compound, 586529, for the treatment of anxiety and depression.

Urocortin 2 for Congestive Heart Failure (CHF) Completes Preclinical Evaluations

In December 2008 the Company completed two preclinical studies for urocortin 2 with favorable outcomes. The two GLP toxicology and safety assessment studies, over 14 days of continuous infusion, were completed in distinct species models, and confirmed the results of the two previous non-GLP studies. The favorable results of these studies should allow urocortin 2 to be infused for periods up to two weeks in duration in humans.

Vesicular Monoamine Transporter 2 Inhibitor (VMAT2)

VMAT2 is a protein concentrated in the human brain that is essential for the transmission of nerve impulses between neurons. The Company has identified a highly selective VMAT2 inhibitor that is effective in regulating the levels of dopamine release during nerve communication, while at the same time having minimal impact on the other monoamines thereby reducing the likelihood of "off target" side effects. This clinical candidate should be effective in the management of hyperkinetic movement disorders characterized by involuntary bodily movements as seen in patients suffering from Tardive Dyskinesia, and Huntington's disease. Additionally, the modulation of dopamine pathways may also be useful for patients suffering fro
'/>"/>

SOURCE Neurocrine Biosciences, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine news :

1. Webcast Alert: Neurocrine Announces 1Q08 Financial Results
2. Neurocrine Announces Closing of $109 Million Sale and Leaseback Agreement for its Real Estate Assets
3. Neurocrine Biosciences to Present at the CIBC World Markets 18th Annual Healthcare Conference
4. Enlight Biosciences Expands to direct up to $52 Million to Transformational Enabling Technologies
5. New Jersey-Based Biotech Start-Up Nexomics Biosciences Gets Off the Ground
6. URMC, Lighthouse Biosciences Awarded U.S. Patent for Diagnostic Technology
7. URMC, Lighthouse Biosciences awarded US patent for diagnostic technology
8. Abbott Completes Acquisition of Ibis Biosciences, a Subsidiary of Isis
9. CeloNova BioSciences Receives FDA Market Approval for Embozene(TM) Color-Advanced Microspheres Embolization Platform
10. Pressure BioSciences, Inc. Announces Restructuring, Significant Cost Reduction Initiatives, and Sharpened Focus
11. Alexander R. Giaquinto, Ph.D., Joins Regado Biosciences as Senior Vice President of Regulatory Affairs and Quality Assurance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... 2014 MMAR Medical is pleased to ... chance for regular customers to enjoy several perks and ... for a wholesale license. It’s a great choice for ... and others who regularly purchase medical braces but could ... your own active lifestyle or those of your club, ...
(Date:8/28/2014)... 28, 2014 On September 1st, the ... Back-to-School campaign. The goal is to help families ... calmly and effectively and without exposures to risky pesticides. ... agree: “Children’s exposures to pesticides should be limited ... , Head lice are often trivialized in the media, ...
(Date:8/27/2014)... Missouri (PRWEB) August 28, 2014 A ... Carey Danis & Lowe reports that the C.R. ... of thousands of consolidated transvaginal mesh lawsuits, recently filed ... PTO #136 pertains to the pretrial discovery process, and ... physically sensitive evidence. , Carey Danis & Lowe is ...
(Date:8/27/2014)... FL (PRWEB) August 27, 2014 ... money-saving dental plans, has launched in the state ... access to quality, affordable dental care services at ... destination for Tennessee consumers looking to save money ... dental rates as a member of discount fee ...
(Date:8/27/2014)... (PRWEB) August 28, 2014 For ... and XML websites, ASP.NET hosting products are very ... ), Arvixe, and FatCow are the best ASP.NET ... has been known as a top web hosting ... for reliability remains with it today. Recently proclaimed ...
Breaking Medicine News(10 mins):Health News:MMAR Medical Announces Customer Membership Program 2Health News:Head Lice Can Be a Public Health Opportunity 2Health News:Head Lice Can Be a Public Health Opportunity 3Health News:Head Lice Can Be a Public Health Opportunity 4Health News:Carey Danis & Lowe Reports On New Court Order in C.R. Bard Transvaginal Mesh MDL 2Health News:DentistSave.com Launches Discount Dental Plans in Tennessee for Consumers, Businesses, and Groups 2Health News:DentistSave.com Launches Discount Dental Plans in Tennessee for Consumers, Businesses, and Groups 3Health News:Top10BestSEOHosting.com Releases the Best ASP.NET Hosting Suppliers of This Year: Hostgator, Arvixe and FatCow 2
... and Medical Center, Phoenix, today announced the signing of ... for the deployment of the company,s state-of-the-art videoconferencing ... be used to connect specialist physicians at the hospital ... will include the Barrow Neurological Institute, as well as ...
... Essential survival gear for parents and guardians raising girls ... Changes (TM) is the leading product to help ... . (Photo: http://www.newscom.com/cgi-bin/prnh/20090512/LA13991 ) WHO: ... are Tara Harrington and Susanne Marcotte-Carroll, two ...
... percent lower in those who take supplements that long, research ... for at least a year before conception, folic acid supplements ... at least 50 percent, University of Texas researchers say. , ... PLoS Medicine , found no link to a reduction in ...
... who has developed a pioneering technique using microwaves to destroy ... UK and other patients are now being treated internationally. ... year die of primary liver cancer, with another million dying ... other tumour sites such as cancer of the colon. ...
... 2009) When Americans were asked to value the ... as they consider spending their own money, they chose ... revealed. , The Spectrum Health Value Study, the first ... representative sample of Americans over the past six months ...
... Human monoclonal antibodies effective against bird and seasonal ... colleagues, working with researchers at the Dana-Farber Cancer ... Prevention, reported the identification of human monoclonal antibodies ... viruses, including avian influenza A (H5N1) virus, previous ...
Cached Medicine News:Health News:St. Joseph's Hospital and Medical Center Signs Agreement for Innovative Video Conferencing Use 2Health News:Changes(TM) Kit for Girls - 'What Every Girl Wants.' 2Health News:Worldwide success in treatment of liver tumors 2Health News:Worldwide success in treatment of liver tumors 3Health News:Access to care leads Americans' priorities in first-ever public study of health value 2Health News:Recent developments at Burnham Institute for Medical Research, May 2009 2Health News:Recent developments at Burnham Institute for Medical Research, May 2009 3Health News:Recent developments at Burnham Institute for Medical Research, May 2009 4Health News:Recent developments at Burnham Institute for Medical Research, May 2009 5
(Date:8/27/2014)... , Aug. 27, 2014  Decision Resources ... specialties (medical oncology, hematology-oncology, rheumatology, gastroenterology, endocrinology and ... trials that a biosimilar has been assessed in ... product they choose to prescribe. ... report entitled Acceptance of Biosimilars Across ...
(Date:8/27/2014)... -- According to the new research ... Chairs, Dental Lasers), Current Trends, Opportunities - Global Forecast ... Market is expected to reach $7,138.9 million by ... a CAGR of 5.7% between 2014 and 2019. ... 61 figures spread through 167 pages and in-depth ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com announces ... in its catalogue: Global Heart Valve ... http://www.reportlinker.com/p02316644/Global-Heart-Valve-Repair-and-Replacement-Market-2014-2018.html About Heart Valve ... the human heart which control the flow of ... with heart valve diseases such as valvular stenosis, ...
Breaking Medicine Technology:Surveyed Physicians Expect to Choose Between Future Biosimilars Based on Robustness and Number of Clinical Trials 2Dental Equipment Market Worth $7,138.9 Million by 2019 2Dental Equipment Market Worth $7,138.9 Million by 2019 3Global Heart Valve Repair and Replacement Market 2014-2018 2Global Heart Valve Repair and Replacement Market 2014-2018 3Global Heart Valve Repair and Replacement Market 2014-2018 4
... mm applier contains 20 titanium clips in the ... in the L size. The appliers are designed ... Auto Suture trocar sleeves, or larger sized trocar ... introduction of the ENDO CLIP clip applier through ...
... The Tissue Lock Clip is designed with ... superior on-vessel clip retention and improved hemostasis., ... design has a 20 percent greater angle ... placement., ,The Reflex® ELC has an ...
Insert only, Pilling-Weck small clip size...
Insert only, Ethicon, medium clip size...
Medicine Products: