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NeuroAIDS is Target of Federal Grant to Children's Hospital
Date:10/15/2009

between both drugs may strengthen the effects of aprepitant without increasing its dosage. The trial will measure antiviral activity as well as changes in depressive behavior and anxiety among the subjects.

Although aprepitant has a central role in the study projects, it may not ultimately be the drug used in future HIV clinics. "Aprepitant is the only FDA-approved drug among NK1R antagonists, but we expect that ultimately another compound in the same class will become a new anti-AIDS drug," says Florin Tuluc, M.D., Ph.D., of Children's Hospital, an expert on cell signaling who is a collaborator in the program. "We believe a NK1R antagonist will have an important role as a novel medicine in treating neuroAIDS."

About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country, ranking second in National Institutes of Health funding. In addition, its unique family-centered care and public service programs have brought the 430-bed hospital recognition as a leading advocate for children and adolescents. For more information, visit http://www.chop.edu.

    CONTACT:
    John Ascenzi
    (Phone): 267-426-6055
    Ascenzi@email.chop.edu

SOURCE The Children's Hospital of Philadelphia


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SOURCE The Children's Hospital of Philadelphia
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