Navigation Links
NeuroAIDS is Target of Federal Grant to Children's Hospital
Date:10/15/2009

n human subjects, with results due to be reported late this year.

In the new grant, one project focuses on cellular mechanisms -- how NK-1R drugs function in human immune cells and brain cells. The project leader is John Wolfe, V.M.D., Ph.D., a Children's Hospital of Philadelphia Research Institute scientist and a Penn professor of Pathology and Medical Genetics with special expertise in genetic and cellular mechanisms in the brain.

A second project addresses immune mechanisms, investigating whether clinical depression makes a person's immune cells more vulnerable to HIV infection. The researchers will also study how aprepitant may have a dual effect, both preventing HIV from entering cells and restoring the immune function of natural killer cells. People with depression show lower levels of natural killer cells, and NK1R drugs may act against depressive behavior. Douglas leads this project, working with co-investigators Jordan Orange, M.D., Ph.D., of Children's Hospital, an expert in natural killer cells, and Dwight Evans, M.D., chair of Psychiatry at the Penn School of Medicine. Evans is internationally prominent for studying the connections between depression and immune function.

The third project is a Phase 1B clinical trial, to be led by Pablo Tebas, M.D., clinical research site principal investigator of the AIDS Clinical Trials Unit at the Hospital of the University of Pennsylvania. That unit participates in IMPAACT -- the International Maternal Pediatric Adolescent AIDS Clinical Trials Group, of which Douglas is the overall principal investigator for IMPAACT's Philadelphia Clinical Trials Unit.

The trial, to be conducted in HIV-infected adult patients already receiving antiretroviral medicines, will test the safety of aprepitant in those patients. A second clinical study will test aprepitant as an antiviral agent in combination with ritonavir, another anti-HIV drug, in patients failing HIV therapy. The interactions
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. A new molecular zip code, and a new drug target for Huntingtons disease
2. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
3. National Council of Negro Women (NCNW) Partners With Sherwin-Williams to Target Lead Risks in Neglected Housing
4. U.S. Health Initiative Targets Aging Hispanics
5. Global Health Project targets reducing AIDS among Indias adolescents
6. Study suggests brain tumors need treatment with multiple targeted drugs
7. GP targets on heart disease should be simpler and based more on treatment and prevention
8. T vs. B: Re-engineered human T cells effectively target and kill cancerous B cells
9. Chronic infection persists by targeting stromal cell network in lymphoid organs
10. Prime Access Creates Groundbreaking Ads Targeting Urban Teens for the White Houses National Youth Anti-Drug Media Campaign
11. International Law Enforcement Operation Targets Underground Manufacture of Anabolic Steroids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... -- Almost 140 people die every year in ... States. But there are several simple ways ... prevention coordinator at Cincinnati Children,s Hospital Medical Center,s ... center news release. "As families begin to ... for parents and children to go over school ...
(Date:8/1/2014)... Illinois (PRWEB) August 01, 2014 As ... across the country, Ronald E. Johnson, Jr. has been ... by AndroGel and other testosterone medications. Since the Fall ... Johnson, P.S.C. have worked diligently to investigate and prosecute ... pulmonary embolisms, and blood clots as a result of ...
(Date:8/1/2014)... August 01, 2014 Market Publishers ... reports have been added to its catalogue. ... Pharmaceutical Ingredients (APIs), Contract Research and Manufacturing Services ... pharma industry drivers include, among others, increasing ageing ... hygiene. In 2015, the pharma market in India ...
(Date:8/1/2014)... HealthDay Reporter FRIDAY, Aug. 1, ... a time-honored destination for a good cut and conversation. ... be the spot to tackle an often overlooked health concern: ... partnership, the U.S. Centers for Disease Control and Prevention, together ... help of barbershop staff to both discuss and diagnose high ...
(Date:8/1/2014)... 2014 Over the past five ... innovative technologies that have enabled cosmetic dentists to ... color. Moreover, the burgeoning elderly population has stimulated ... ailments. Due to long-term use of medications, which ... demanded dental fillings, veneers and implants. As more ...
Breaking Medicine News(10 mins):Health News:Expert Offers School Bus Safety Tips 2Health News:Ron Johnson Named Co-Lead Counsel in Lawsuits for Men Injured by AndroGel and Testosterone 2Health News:In-demand Markets Research Reports by Kelly Scientific Publications Now Available at MarketPublishers.com 2Health News:In-demand Markets Research Reports by Kelly Scientific Publications Now Available at MarketPublishers.com 3Health News:Barbershops Join Fight Against High Blood Pressure in Black Men 2Health News:Barbershops Join Fight Against High Blood Pressure in Black Men 3Health News:Cosmetic Dentists in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Cosmetic Dentists in the US Industry Market Research Report from IBISWorld Has Been Updated 3
... also available in Chinese ., , ... side effects of chemotherapy in cancer patients by stimulating ... in mice suggests., The research will appear in the ... which is published by AAAS, the nonprofit science ...
... A paper by Indiana University-Purdue University Indianapolis ... to improve identification of breast cancer tissue by ... scientific paper in the "bioinformatics and biomedical applications ... The best scientific paper award ...
... WEDNESDAY, Aug. 18 (HealthDay News) -- With their enticing cool ... the most controversial products made by the tobacco industry. ... of smokers aged 12 to 17 using menthol cigarettes, according ... Most black teenaged smokers -- and 82.7 percent of black ...
... Center in Israel have determined that the use ... outcome for patients undergoing percutaneous coronary intervention (PCI), ... appear in the September issue of Catheterization ... Wiley-Blackwell on behalf of The Society for Cardiovascular ...
... Aug. 19, 2010 A pediatric urologist at UT ... for young girls who have absent or malformed vaginas, ... Unknown causes and certain genetic disorders can cause ... other birth defects that can accompany the vaginal problems, ...
... To improve the quality of HIV care and treatment ... and monitoring of antiretroviral therapy should be adopted uniformly, according ... The work group,s study results appear in the current ... study shows how national HIV quality performance measures were developed, ...
Cached Medicine News:Health News:Ancient Chinese medicine may help chemotherapy patients 2Health News:FDA Mulling Ban on Menthol Cigarettes 2Health News:FDA Mulling Ban on Menthol Cigarettes 3Health News:FDA Mulling Ban on Menthol Cigarettes 4Health News:Drug-eluting stents confirmed safe, effective for long-term use 2Health News:Pediatric urologist performs innovative procedure for girls with rare vaginal defects 2Health News:Uniform, national measures should define HIV/AIDS care 2
(Date:7/31/2014)... Pharmacyclics, Inc. (the "Company") (Nasdaq: PCYC ) today ... June 30, 2014. Financial Results for the Six ... revenue for the quarter ended June 30, 2014 increased to ... 30, 2013 primarily due to IMBRUVICA ® (ibrutinib) net ... for the six months ended June 30, 2014 increased to ...
(Date:7/31/2014)... VIEW, Calif. , July 31, 2014 /PRNewswire/ ... today provided an update on its pipeline and ... 2014, Alexza expects to initiate a Phase 2a ... is being developed for the management of patients ... two new Staccato -based product candidates for ...
(Date:7/31/2014)... , July 31, 2014 Rock Creek Pharmaceuticals, ... it has initiated the development of its lead molecule, ... that it has selected Quotient Clinical, The Translational Pharmaceutics ... (UK) to run its early development programs. ... Application (CTA) by the end of the third quarter ...
Breaking Medicine Technology:Pharmacyclics Reports Second Quarter 2014 Results 2Pharmacyclics Reports Second Quarter 2014 Results 3Pharmacyclics Reports Second Quarter 2014 Results 4Pharmacyclics Reports Second Quarter 2014 Results 5Pharmacyclics Reports Second Quarter 2014 Results 6Pharmacyclics Reports Second Quarter 2014 Results 7Pharmacyclics Reports Second Quarter 2014 Results 8Pharmacyclics Reports Second Quarter 2014 Results 9Pharmacyclics Reports Second Quarter 2014 Results 10Pharmacyclics Reports Second Quarter 2014 Results 11Pharmacyclics Reports Second Quarter 2014 Results 12Pharmacyclics Reports Second Quarter 2014 Results 13Pharmacyclics Reports Second Quarter 2014 Results 14Pharmacyclics Reports Second Quarter 2014 Results 15Pharmacyclics Reports Second Quarter 2014 Results 16Pharmacyclics Reports Second Quarter 2014 Results 17Pharmacyclics Reports Second Quarter 2014 Results 18Pharmacyclics Reports Second Quarter 2014 Results 19Pharmacyclics Reports Second Quarter 2014 Results 20Pharmacyclics Reports Second Quarter 2014 Results 21Pharmacyclics Reports Second Quarter 2014 Results 22Pharmacyclics Reports Second Quarter 2014 Results 23Pharmacyclics Reports Second Quarter 2014 Results 24Pharmacyclics Reports Second Quarter 2014 Results 25Pharmacyclics Reports Second Quarter 2014 Results 26Pharmacyclics Reports Second Quarter 2014 Results 27Pharmacyclics Reports Second Quarter 2014 Results 28Alexza Provides Pipeline Update 2Alexza Provides Pipeline Update 3Alexza Provides Pipeline Update 4Alexza Provides Pipeline Update 5Alexza Provides Pipeline Update 6Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 2Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 3Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 4
... March 30, 2011 Neurocrine Biosciences, Inc. (Nasdaq: ... Executive Officer of Neurocrine Biosciences, will be presenting at the ... The live presentation takes place on Wednesday, ... a.m. Pacific Time.  The presentation will be webcast and may ...
... 2011 CANTEL MEDICAL CORP. (NYSE: ... President, will be presenting at the Needham & Company, LLC ... 4:00 PM EDT on Wednesday, April 6, 2011 at the ... immediately following the presentation.  In addition, Mr. Segel will be ...
Cached Medicine Technology:
... Parathyroid hormone (PTH) is synthesized ... secreted in response to decreased extracellular ... enhancing bone resorption and decreasing calcium ... into the circulation, intact PTH is ...
... the adrenal cortex and, to a lesser ... a precursor in testosterone and estrogen synthesis, ... at ~10% that of testosterone [1]. However, ... women, DHEA is an important androgen as ...
... steroid, is one of the most potent ... testosterone is secreted primarily by the testes ... peripheral conversion of androstenedione [2]. In adult ... 50% of serum testosterone is derived from ...
... Thyroxine (T4) is the primary active ... the thyroid gland [1]. T4 is synthesized ... iodide trapping by the follicular cells, (ii) ... substrate leading to formation of 3-monoiodotyrosine and ...
Medicine Products: