Navigation Links
NeuroAIDS is Target of Federal Grant to Children's Hospital
Date:10/15/2009

cells -- inhibits HIV from entering those cells by down-regulating, or dialing down the activity, of CCR5, a major HIV co-receptor on cell surfaces.

The current grant program will investigate the most effective ways to use NK1R antagonists to block HIV from replicating, with the aim of bringing those agents closer to use as clinical treatments. One project will use a specific NK-1R antagonist, the FDA-approved anti-nausea drug aprepitant, in a clinical trial in adult patients with HIV infection. It will be a Phase 1B trial, an early-stage test designed primarily to determine drug safety. It is also intended to test the concept that the drug may reduce virus levels in patients in whom highly active antiretroviral therapy (HAART) has failed.

"Our major goal is to establish proof-of-principle that this class of drug can reduce virus levels and otherwise benefit patients," said Douglas. "We envision NK-1R antagonists as a potential key element of a combination therapy for patients with HIV infection."

An estimated 50 percent of AIDS patients suffer some form of neuropsychiatric impairment, such as HIV-associated dementia, which is not well controlled by current antiretroviral drugs that have limited ability to cross the blood-brain barrier. Furthermore, while current drugs have improved patient survival, HIV continues to develop drug resistance, while neurocognitive deficits persist, compelling researchers to devise new antiviral therapies.

NK1R antagonists show promise as potential new treatments, but much remains to be learned about their biology and activity. Douglas' new grant encompasses cell studies, translational work to apply basic knowledge to treatments, and a clinical trial. The new grant builds on a previous four-year NIMH grant just concluding. That grant included an animal study that showed aprepitant was tolerated in rhesus macaque monkeys. The grant also supported a double-blind clinical trial of aprepitant i
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. A new molecular zip code, and a new drug target for Huntingtons disease
2. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
3. National Council of Negro Women (NCNW) Partners With Sherwin-Williams to Target Lead Risks in Neglected Housing
4. U.S. Health Initiative Targets Aging Hispanics
5. Global Health Project targets reducing AIDS among Indias adolescents
6. Study suggests brain tumors need treatment with multiple targeted drugs
7. GP targets on heart disease should be simpler and based more on treatment and prevention
8. T vs. B: Re-engineered human T cells effectively target and kill cancerous B cells
9. Chronic infection persists by targeting stromal cell network in lymphoid organs
10. Prime Access Creates Groundbreaking Ads Targeting Urban Teens for the White Houses National Youth Anti-Drug Media Campaign
11. International Law Enforcement Operation Targets Underground Manufacture of Anabolic Steroids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... July 29, 2014 Winter is here ... Thursday afternoon in Sydney’s central business district. That is, ... Maori costume transformed the otherwise ordinary day into a ... singers are ardent advocates of The Truth About Drugs, ... of Scientology . They woke up the city with ...
(Date:7/29/2014)... Daily Gossip writes in its Fibroids Miracle review that ... teach users how to permanently eliminate uterine fibroids. The system ... over the world. , They have been able to ... quickly as 12 hours. This means that pain and other ... The Fibroids Miracle review also indicates that the method was ...
(Date:7/29/2014)... 29, 2014 Daily Gossip indicates in its ... tips to gain beautiful and clear skin in just 30 ... see these positive results even sooner than that. The new ... who used this step by step program, too. , ... for years. Mike battled this condition for a decade and ...
(Date:7/29/2014)... procedures using stem cells are running far ahead of ... a review in the August issue of ... journal of the American Society of Plastic Surgeons ... the marketplace is saturated with unsubstantiated and sometimes fraudulent ... Michael T. Longaker of Stanford University Medical Center and ...
(Date:7/29/2014)... 2014 As the Ebola outbreak in Liberia ... to both purchase critical emergency supplies locally, as well as ... These supplies will contain materials used to control the spread ... areas of the country. , With a large programmatic ... to the Ebola outbreak in the region. The current epidemic ...
Breaking Medicine News(10 mins):Health News:Sydney Business District “Rocked” by The Truth About Drugs 2Health News:Amanda Leto’s Fibroids Miracle Review Reveals Clinically Proven Uterine Fibroids Cure System 2Health News:Acne No More Review Reveals Most Effective Acne Cure Program 2Health News:Beware of claims about cosmetic stem cells procedures, says review in Plastic and Reconstructive Surgery 2Health News:PCI Responds to Ebola Outbreak in Liberia with Supplies, Awareness Campaigns 2Health News:PCI Responds to Ebola Outbreak in Liberia with Supplies, Awareness Campaigns 3
... Smart for Life(TM), the all-natural weight management program, opened in ... The Raimondo family began their weight-loss journey on the Smart ... of 235 lbs. for 6 family members. As friends and ... Raimondo envisioned an exciting business opportunity. , "Smart ...
... Haemonetics Corporation (NYSE: HAE ) will announce its ... release and 10:00 am (EST) webcast. , Webcast Link: ... from November 2, 2009 after 1:00 pm to November 9, ... Julie Fallon, Tel. (781) 356-9517, ...
... (Nasdaq: JMBA ) - As a part of their ... will be bringing some unexpected feel good boosts into people,s ... and Golden State visitors to free cable car rides this ... Jambassador, will bring unexpected cheer to riders as he makes ...
... ... ... has recently been promoted to Senior Vice President of Operations at Jackson & Coker ... , , , , ,"This position has been vacant for a while and ...
... ... announced the launch of their "Tats for Tatas" fundraising campaign that will ... In the company,s concerted efforts to raise awareness and funds for ... In addition, the company will be donating 10% of all proceeds from ...
... ... book Knockout: Interviews with Doctors Who are Curing Cancer and How to Prevent Getting It ... ... eight medical doctors featured in Suzanne Somers’ new book Knockout: Interviews with Doctors Who are ...
Cached Medicine News:Health News:Smart for Life(TM) Center Opens in Ottawa 2Health News:Surprise! Jamba Juice Treats Lucky San Francisco Cable Car Passengers to Free Rides on Saturday, October 17 2Health News:Surprise! Jamba Juice Treats Lucky San Francisco Cable Car Passengers to Free Rides on Saturday, October 17 3Health News:Jackson & Coker Promotes Tony Rico to Senior VP of Operations 2Health News:Atomic Tattoos Announces "Tats for Tatas" October Fundraising Event to Benefit Local Breast Cancer Research 2Health News:Suzanne Somers Highlights Dr. Stephen Sinatra in Chapter for New Cancer Book 2
(Date:7/29/2014)... , July 29, 2014 Regado Biosciences, ... focused on the Phase 3 clinical development of Revolixys™ ... antithrombotic drug system, today announced that it will hold ... Aug. 12, 2014, at 8:30 a.m. EDT to discuss ... Interested participants and investors may access the ...
(Date:7/29/2014)... VIEW, Calif. , July 29, 2014  Alexza ... that it is participating in two healthcare conferences during ... Conference and the Morgan Stanley Global Healthcare 2014 Conference. ... Morgan Stanley Conference.  The details on each event are ... Conference, Monday, August 11, 2014 in Boston ...
(Date:7/29/2014)... July 29, 2014  Landauer, Inc. (NYSE: ... radiation measurement and monitoring, outsourced medical physics services and ... for the fiscal third quarter 2014 after the market ... The Company will host a conference call for investors ... Time (10 a.m. Eastern Time). Investors may access the ...
Breaking Medicine Technology:Regado Biosciences to Provide Second Quarter 2014 Financial Results and Corporate Highlights 2Regado Biosciences to Provide Second Quarter 2014 Financial Results and Corporate Highlights 3Alexza Pharmaceuticals Announces Participation in Upcoming Investor Conferences 2Alexza Pharmaceuticals Announces Participation in Upcoming Investor Conferences 3Landauer, Inc. Sets Date and Time for Announcement of Fiscal Third Quarter 2014 Results 2
... The MicroTouch LP (low profile) is ... with a fixed fluoroscopy/x-ray gantry. The MicroTouch ... opposite the gantry and allows the user ... fluoroscopy ,and x-ray without loss of ...
Floor stand stabilizer system...
The robust, easy to maneuver floor-mounted stepper/stabilizer, offers strength and stability that has made this unit one of the most widely accepted floor fixation devices in the industry....
... of a welded titanium capsule containing either ... beads. The capsule body also contains ... x-ray markers to identify the source location ... non-sterile when shipped and must be sterilized ...
Medicine Products: