Navigation Links
Neural interface for prosthesis can restore function in motor control brain areas

Amsterdam, NL, August 20, 2012 Amputation disrupts not only the peripheral nervous system but also central structures of the brain. While the brain is able to adapt and compensate for injury in certain conditions, in amputees the traumatic event prevents adaptive cortical changes. A group of scientists reports adaptive plastic changes in an amputee's brain following implantation of multielectrode arrays inside peripheral nerves. Their results are available in the current issue of Restorative Neurology and Neuroscience.

"We found that a neurally-interfaced hand prosthesis re-established communication between the central and peripheral nervous systems, not only restructuring the areas directly responsible for motor control but also their functional balance within the bi-hemispheric system necessary for motor control," says lead investigator Camillo Porcaro, PhD, of the Institute of Neuroscience, Newcastle University, Medical School, Newcastle upon Tyne, UK and the Institute of Cognitive Sciences and Technologies (ISTC) National Research Council (CNR).

A 26-year old male with a left arm amputation was implanted with four microelectrode arrays in the ulnar and median nerves of his stump for four weeks. Prior to implantation, he was trained for two weeks by video to perform three specific movements with his phantom hand. During the experimental period, he underwent intensive training to control a hand prosthesis using the implanted microelectrodes to perform the same hand grip tasks. Together with visual feedback from the prosthesis, the patient received sensory feedback from an experimenter, who delivered electrical pulses to the nerves activated by each movement. EEG signals were recorded as the patient moved his right hand and the prosthesis.

The patient's right hand movement showed clear activation of the primary sensory and motor areas for right hand movement, on the left side of the brain. Prior to implantation, commands to move the phantom left hand triggered the primary sensory and motor areas on the left side of the brain, and the pre-motor and supplementary motor cortices on both sides of the brain. No primary motor cortex movement was found on the right side of the brain, as would be expected.

After the four weeks of prosthesis motor control training with implanted microelectrodes, cerebral activation changed markedly. Cortical recruitment became almost symmetrical with right hand movements. The presence of intra-fascicular electrodes allowed new signals to be delivered through peripheral nerves towards the cortex and produced an intensive exchange of sensori-motor afferent and efferent inputs and outputs. Four weeks of training led to a new functional recruitment of sensorimotor areas devoted to hand control.

"Taken together, the results of this study confirm that neural interfaces are optimal candidates for hand prosthesis control," says Dr. Porcaro. "They establish communication channels needed for natural control of the prosthesis. Furthermore, neural interfaces recreate the connection with the environment that promotes restorative neuroplasticity. Bi-hemispheric networks regain the physiological communication necessary for motor control."

Contact: Daphne Watrin
IOS Press

Related medicine news :

1. IBN discovers human neural stem cells with tumor targeting ability
2. Small neural focus groups predict anti-smoking ad success
3. Growing up as a neural stem cell: The importance of clinging together and then letting go
4. Charting autisms neural circuitry
5. Neural precursor cells induce cell death in certain brain tumors
6. Classifying neural circuit dysfunctions using neuroeconomics
7. UC Santa Barbaras Kavli Institute receives 2 grants to explore interface of physics and biology
8. New type of retinal prosthesis could better restore sight to blind, Stanford study says
9. New technique may help severely damaged nerves regrow and restore function
10. Doctors Restore Some Hand Function to Quadriplegic Patient
11. Researchers restore neuron function to brains damaged by Huntingtons disease
Post Your Comments:
(Date:11/27/2015)... ... ... According to an article published November 13th on, much ... revolved around the fact that proper dental care, both at-home and in the dental ... periodontal disease (more commonly referred to as gum disease) and diabetes. According to Dr. ...
(Date:11/27/2015)... ... November 27, 2015 , ... The rapid speed at ... people age, more care is needed, especially with Alzheimer’s, dementia and other cognitive ... being overworked. The forgotten part of this equation: 80 percent of medical care ...
(Date:11/27/2015)... PA (PRWEB) , ... November 27, 2015 , ... ... how filthy the toilets were," said an inventor from Hillside, N.J. "Many people ... improved seat cover so that individuals will always be protected from germs." , ...
(Date:11/27/2015)... ... November 27, 2015 , ... ProSidebar: Fashion ... Cut Pro X. With ProSidebar: Fasion, video editors can easily add an informative ... a minimalist title opener. Utilize presets featuring self-animating drop zones, lines, bars, and ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... of the well-respected Microsoft Dynamics SL User Group (MSDSLUG). Recognized as Microsoft’s official ... independent group of Microsoft Dynamics SL software users, partners, industry experts and representatives. ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... announced the addition of the  "2016 ... the Global Cell Surface Testing Market: ... report to their offering.  --> ... addition of the  "2016 Future Horizons ...
(Date:11/26/2015)... Research and Markets ( ) has ... Market by Type (Dressings, Therapy Devices, Active Wound Care), ... Facility), and Geography - Global Forecast to 2020" ... --> The purpose of this report ... the global advanced wound care market. It involves deep ...
(Date:11/26/2015)... 26, 2015 ) ... Administration of High Viscosity Drugs" report to ... announced the addition of the "Self Administration ... offering. --> Research and Markets ( ... "Self Administration of High Viscosity Drugs" ...
Breaking Medicine Technology: