Navigation Links
Neural interface for prosthesis can restore function in motor control brain areas
Date:8/20/2012

Amsterdam, NL, August 20, 2012 Amputation disrupts not only the peripheral nervous system but also central structures of the brain. While the brain is able to adapt and compensate for injury in certain conditions, in amputees the traumatic event prevents adaptive cortical changes. A group of scientists reports adaptive plastic changes in an amputee's brain following implantation of multielectrode arrays inside peripheral nerves. Their results are available in the current issue of Restorative Neurology and Neuroscience.

"We found that a neurally-interfaced hand prosthesis re-established communication between the central and peripheral nervous systems, not only restructuring the areas directly responsible for motor control but also their functional balance within the bi-hemispheric system necessary for motor control," says lead investigator Camillo Porcaro, PhD, of the Institute of Neuroscience, Newcastle University, Medical School, Newcastle upon Tyne, UK and the Institute of Cognitive Sciences and Technologies (ISTC) National Research Council (CNR).

A 26-year old male with a left arm amputation was implanted with four microelectrode arrays in the ulnar and median nerves of his stump for four weeks. Prior to implantation, he was trained for two weeks by video to perform three specific movements with his phantom hand. During the experimental period, he underwent intensive training to control a hand prosthesis using the implanted microelectrodes to perform the same hand grip tasks. Together with visual feedback from the prosthesis, the patient received sensory feedback from an experimenter, who delivered electrical pulses to the nerves activated by each movement. EEG signals were recorded as the patient moved his right hand and the prosthesis.

The patient's right hand movement showed clear activation of the primary sensory and motor areas for right hand movement, on the left side of the brain. Prior to implantation, commands to move the phantom left hand triggered the primary sensory and motor areas on the left side of the brain, and the pre-motor and supplementary motor cortices on both sides of the brain. No primary motor cortex movement was found on the right side of the brain, as would be expected.

After the four weeks of prosthesis motor control training with implanted microelectrodes, cerebral activation changed markedly. Cortical recruitment became almost symmetrical with right hand movements. The presence of intra-fascicular electrodes allowed new signals to be delivered through peripheral nerves towards the cortex and produced an intensive exchange of sensori-motor afferent and efferent inputs and outputs. Four weeks of training led to a new functional recruitment of sensorimotor areas devoted to hand control.

"Taken together, the results of this study confirm that neural interfaces are optimal candidates for hand prosthesis control," says Dr. Porcaro. "They establish communication channels needed for natural control of the prosthesis. Furthermore, neural interfaces recreate the connection with the environment that promotes restorative neuroplasticity. Bi-hemispheric networks regain the physiological communication necessary for motor control."


'/>"/>
Contact: Daphne Watrin
d.watrin@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Related medicine news :

1. IBN discovers human neural stem cells with tumor targeting ability
2. Small neural focus groups predict anti-smoking ad success
3. Growing up as a neural stem cell: The importance of clinging together and then letting go
4. Charting autisms neural circuitry
5. Neural precursor cells induce cell death in certain brain tumors
6. Classifying neural circuit dysfunctions using neuroeconomics
7. UC Santa Barbaras Kavli Institute receives 2 grants to explore interface of physics and biology
8. New type of retinal prosthesis could better restore sight to blind, Stanford study says
9. New technique may help severely damaged nerves regrow and restore function
10. Doctors Restore Some Hand Function to Quadriplegic Patient
11. Researchers restore neuron function to brains damaged by Huntingtons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer ... through a fitness app. The fitness app plans to fix the two major problems leading ... a one size fits all type program , They don’t eliminate all the ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , ... Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , ... our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced ... feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as a ... has released tools for healthy coping following a traumatic event. , Trauma sufferers tend ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: ... 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) assay ... sepsis or septic shock. With this clearance, Roche is ... a fully integrated solution for sepsis risk assessment and ... with bacterial infection and PCT levels in blood can ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... 23, 2016 Bracket , a leading clinical ... generation clinical outcomes platform, Bracket eCOA (SM) 6.0, at ... 26 – 30, 2016 in Philadelphia , ... Outcome Assessment product of its kind to fully integrate with ... Bracket eCOA 6.0 is a flexible platform for electronic clinical ...
Breaking Medicine Technology: