Navigation Links
Neural interface for prosthesis can restore function in motor control brain areas
Date:8/20/2012

Amsterdam, NL, August 20, 2012 Amputation disrupts not only the peripheral nervous system but also central structures of the brain. While the brain is able to adapt and compensate for injury in certain conditions, in amputees the traumatic event prevents adaptive cortical changes. A group of scientists reports adaptive plastic changes in an amputee's brain following implantation of multielectrode arrays inside peripheral nerves. Their results are available in the current issue of Restorative Neurology and Neuroscience.

"We found that a neurally-interfaced hand prosthesis re-established communication between the central and peripheral nervous systems, not only restructuring the areas directly responsible for motor control but also their functional balance within the bi-hemispheric system necessary for motor control," says lead investigator Camillo Porcaro, PhD, of the Institute of Neuroscience, Newcastle University, Medical School, Newcastle upon Tyne, UK and the Institute of Cognitive Sciences and Technologies (ISTC) National Research Council (CNR).

A 26-year old male with a left arm amputation was implanted with four microelectrode arrays in the ulnar and median nerves of his stump for four weeks. Prior to implantation, he was trained for two weeks by video to perform three specific movements with his phantom hand. During the experimental period, he underwent intensive training to control a hand prosthesis using the implanted microelectrodes to perform the same hand grip tasks. Together with visual feedback from the prosthesis, the patient received sensory feedback from an experimenter, who delivered electrical pulses to the nerves activated by each movement. EEG signals were recorded as the patient moved his right hand and the prosthesis.

The patient's right hand movement showed clear activation of the primary sensory and motor areas for right hand movement, on the left side of the brain. Prior to implantation, commands to move the phantom left hand triggered the primary sensory and motor areas on the left side of the brain, and the pre-motor and supplementary motor cortices on both sides of the brain. No primary motor cortex movement was found on the right side of the brain, as would be expected.

After the four weeks of prosthesis motor control training with implanted microelectrodes, cerebral activation changed markedly. Cortical recruitment became almost symmetrical with right hand movements. The presence of intra-fascicular electrodes allowed new signals to be delivered through peripheral nerves towards the cortex and produced an intensive exchange of sensori-motor afferent and efferent inputs and outputs. Four weeks of training led to a new functional recruitment of sensorimotor areas devoted to hand control.

"Taken together, the results of this study confirm that neural interfaces are optimal candidates for hand prosthesis control," says Dr. Porcaro. "They establish communication channels needed for natural control of the prosthesis. Furthermore, neural interfaces recreate the connection with the environment that promotes restorative neuroplasticity. Bi-hemispheric networks regain the physiological communication necessary for motor control."


'/>"/>
Contact: Daphne Watrin
d.watrin@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Related medicine news :

1. IBN discovers human neural stem cells with tumor targeting ability
2. Small neural focus groups predict anti-smoking ad success
3. Growing up as a neural stem cell: The importance of clinging together and then letting go
4. Charting autisms neural circuitry
5. Neural precursor cells induce cell death in certain brain tumors
6. Classifying neural circuit dysfunctions using neuroeconomics
7. UC Santa Barbaras Kavli Institute receives 2 grants to explore interface of physics and biology
8. New type of retinal prosthesis could better restore sight to blind, Stanford study says
9. New technique may help severely damaged nerves regrow and restore function
10. Doctors Restore Some Hand Function to Quadriplegic Patient
11. Researchers restore neuron function to brains damaged by Huntingtons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... ... Infallible Characteristics of Christ”: a fascinating and entrancing novel exploring the gifts and ... author, Rev. Dr. Robert W. Thomas, the third of seven siblings. He was a ... pastor for over fifteen years. He is a graduate of N.C. College of Theology ...
(Date:1/22/2017)... Frisco, TX (PRWEB) , ... January 22, 2017 , ... ... and provide slow results. Often the results of a simple test will take days ... review. Any Lab Test Now offers customers direct access to their lab tests, bypassing ...
(Date:1/21/2017)... MALO, FRANCE (PRWEB) , ... January 21, 2017 , ... ... of the Indian Ocean, isolated from the rest of the world with ZANZIBAR SHOWER ... East Africa, Phytocéane used key ingredients, Virgin Coconut Oil and moisturizing vegetal coral to ...
(Date:1/21/2017)... ... January 21, 2017 , ... The Nobel Biocare™ dental implant ... media for its creos™ line of bone regenerative products. Specifically, the ... he utilizes creos™ allo.gain™ bone graft for a variety of bone reconstruction procedures. ...
(Date:1/20/2017)... ... 2017 , ... Doctor C LLC, a company based out of Arizona that ... continue the marketing and distribution of its product, The Right C. , The Right ... absorption than traditional vitamin C supplements. At the trade show, Doctor C had the ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... Research and Markets has announced the addition of the ... to their offering. ... This research service on the global pharmaceutical stability testing market ... of the key participants in the market. The ... 2020. The market is expected to grow at a CAGR of ...
(Date:1/20/2017)... January 20, 2017 ... an Nothilfe   Die internationale humanitäre Stadt soll ... zu schaffen   Seine Hoheit Scheich ... VAE sowie Herrscher von Dubai , ... der Hilfe (International Humanitarian City IHC) zu verdreifachen, um ...
(Date:1/19/2017)... , Jan. 19, 2017 The ... 233.7 billion by 2025, according to a new ... is anticipated to be predominantly driven by high ... into the large-scale production of new and therapeutically ... influx of drugs at an unprecedented rate into ...
Breaking Medicine Technology: