Navigation Links
Nerve growth factors elevated in pancreatic cancer model
Date:6/19/2012

LAKE TAHOE, Nev. Severe pain is a major symptom of pancreatic cancer. The results of a new study show that four different factors involved in the growth and maintenance of nerves are elevated in a mouse model of pancreatic cancer. This is a step forward in understanding the relationship between the development of pain and the progression of pancreatic cancer.

"When other researchers have looked at samples of pancreatic cancer, they have described perineural tumor invasion in as many as 90 to 100 percent of cases," said Rachelle E. Stopczynski, a M.D./Ph.D. student at the University of Pittsburgh in Pa. "We used a mouse model of pancreatic cancer to look at what drives these interactions, and to investigate what role tumor-nerve interactions play in cancer progression."

She presented these findings at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held here June 18-21.

Stopczynski and colleagues measured the levels of neurotrophic factors, which are proteins in charge of the growth and maintenance of nerve cells, in the pancreata of mice with a condition modeling pancreatic cancer and healthy controls aged between 16 and 30 weeks. They also measured the density and distribution of nerve fibers in the pancreas and observed levels of physical activity.

Expression levels of four neurotrophic factors were higher in the pancreata of mice with pancreatic cancer. Nerve bundles were also observed to be larger and the overall physical activity undertaken by the mice with pancreatic cancer was reduced.

This adds important information to our understanding of pancreatic cancer, especially since not all cancers invade peripheral nerves as pancreatic tumor cells do, and not all cancers cause the same level of visceral pain, according to Stopczynski.

"A tumor invading a nerve is going to damage that nerve, causing pain. The nerve can also shield the tumor cells from chemotherapeutic drugs, while at the same time serving as a pathway for tumor cells to spread to other organs. Therefore, these interactions could be responsible for different aspects of cancer progression as well as the development of pain," she said.


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Sleep Apnea May Be Linked to Nerve Damage in Diabetics
2. Exercise Appears to Ease Nerve-Damage Pain in Rat Study
3. How does exercise affect nerve pain?
4. New embryonic stem cell line will aid research on nerve condition
5. New technique may help severely damaged nerves regrow and restore function
6. Scientists discover mechanism that promotes lung cancer growth and survival
7. Disease that stunts infants growth traced to same gene that makes kids grow too fast
8. Mutations impair childhood growth and development by disrupting organization of chromosome pairs
9. Report using private health claims data shows prices are driving health spending growth
10. Low oxygen levels could drive cancer growth
11. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... ... June 28, 2017 , ... Continually ... 50ml Liquid Stevia Sweet Drops™ have received the Non-GMO Project Verified seal. All ... the Non-GMO Project, the only third-party verification for non-GMO foods and products in ...
(Date:6/28/2017)... VA (PRWEB) , ... June 28, 2017 , ... Guide ...      , No matter on which side of the Atlantic devicemakers do ... device regulations they have to follow. , In addition to the full text of ...
(Date:6/28/2017)... ... 28, 2017 , ... Anyone with a remote control has seen the never-ending twists on the ... flipper will get rich in no time. But what about the buyers of the ... the buyer of a flipped house. An email recently sent to Gary Case said, ...
(Date:6/28/2017)... ... June 28, 2017 , ... David B. Sosin, a founding partner at the law ... post of 2nd Vice President for the Illinois State Bar Association , in accordance ... 3rd Vice President in 2016 following a state-wide election and served in that capacity for ...
(Date:6/28/2017)... Jupiter, FL (PRWEB) , ... June 28, 2017 , ... ... in an upcoming episode of the award winning television series, scheduled to broadcast fourth ... Pure Line Seeds originated as a regional supplier of garden pea seed. As demand ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... N.C. , June 14, 2017  In 2016, ... Creative Startups pitch competition and came away ... reality platform is described by Forbes as "entering the ... American Medical Association as teaching "empathy to medical professionals ... the startup was recently named a finalist for the ...
(Date:6/11/2017)... and Company (NYSE: LLY ) announced today ... an investigational treatment for the prevention of episodic and ... endpoints for galcanezumab compared to placebo at both studied ... REGAIN) will be presented today at the American Headache ... . "The detailed Phase 3 ...
(Date:6/9/2017)... INDIANAPOLIS , June 9, 2017 More ... a further effort to help spread lessons learned from ... the International Diabetes Federation (IDF) and Eli Lilly and ... for the second phase of the Bringing Research in ... reaffirming their commitment to helping people with diabetes effectively ...
Breaking Medicine Technology: