Navigation Links
NeoVista Presents Interim Study Results of Novel Therapy for the Treatment of Neovascular Age-Related Macular Degeneration
Date:10/27/2009

Data suggests that Epimacular Brachytherapy may reduce the burden of treatment and further improve Visual Acuity

San Francisco, CA (PRWEB) October 27, 2009 -- NeoVista, Inc. made public at the American Academy of Ophthalmology meeting the company's interim study results from the preliminary study MERITAGE-I. The study was designed to examine the company's novel epimacular brachytherapy procedure when used in patients that require chronic therapy with anti-VEGF agents on an ongoing basis to control their neovascular AMD. The study enrolled patients that had as many as 23 injections of anti-VEGF therapy before receiving epimacular brachytherapy. All patients that entered the study were required to have received a minimum of 8 injections in the past 12 months or 6 injections in the past 6 months preceding enrollment. Preliminary study results (n=16) suggest that a single procedure of epimacular brachytherapy can further improve visual acuity in a majority of this patient population while decreasing the number of injections required based on Optical Coherence Tomography imaging after the brachytherapy procedure. Most importantly, 63% of patients enrolled in the study experienced improvement in their visual acuity while 50% of patients gained 5 or more letters of visual acuity at 6 months.

"MERITAGE-I is the first of its kind study designed to evaluate the potential role of our device in decreasing the current burden of treatment while maintaining or improving visual acuity," said John N. Hendrick, President and CEO of NeoVista. "Data from recent randomized trials suggest that most patients suffering from neovascular AMD will require treatment on an ongoing basis for an indefinite period of time. We are very excited that our device has the potential to significantly decrease the number of injections administered in this patient population and may also improve visual acuity in a majority of cases."

In contrast to other forms of radiation therapy for wet AMD, NeoVista's approach delivers a focused dose of energy directly to the choroidal neovascular lesion without damaging the adjacent healthy retinal vasculature. Utilizing strontium 90, the targeted energy is delivered to a an area up to 3 mm in depth and up to 5.4 mm in diameter. Importantly for patients, the systemic exposure to radiation is minimal, as the effective dose to the entire body from NeoVista's epimacular device is less than that from a typical chest x-ray.

The ongoing multicenter MERITAGE study enrolled 50 trial participants (with a mean age of 79 years) at two centers in the US, one in UK, and two in Israel. These patients, with predominantly classic, minimally classic, or occult (with no classic) choroidal neovascularization (CNV), received a single exposure of epimacular brachytherapy after having received a minimum of 8 injections of anti-VEGF therapy in the past 12 months or 6 injections of anti-VEGF therapy in the past 6 months preceding enrollment. Additional anti-VEGF therapy was delivered based upon strict re-treatment criteria and the investigator's evaluation of disease activity.

There were a limited number of adverse events in the trial which were related to the vitrectomy procedure (subconjunctival hemorrhage, vitreous hemorrhage, and cataract formation), rather than the epimacular brachytherapy. To date, no instances of radiation toxicity have been reported.

The data were presented by Pravin U. Dugel, MD, managing partner, Retina Consultants of Arizona, Phoenix, AZ. "The potential of this treatment is enormous," said Dr. Dugel. "I believe that epimacular brachytherapy, unlike anti-VEGF therapy alone offers a broad spectrum of activity and may therefore inhibit the multiple disease processes involved in the pathology of neovascular AMD."

NeoVista recently completed enrollment in the company's first pivotal trial, CABERNET (CNV Secondary to AMD Treated with BEta RadiatioN Epiretinal Therapy). CABERNET is a multicenter, randomized, controlled study that has enrolled over 450 subjects at 45 sites worldwide, and is evaluating the safety and efficacy of NeoVista's therapy delivered concomitantly with the FDA-approved anti-VEGF therapy Lucentis® (ranibizumab) versus Lucentis alone.

About NeoVista, Inc.
NeoVista, Inc. is a privately held medical device company based in Fremont, California. The company's first commercial product, the VIDION® ANV® Therapy System, is cleared for commercial sale in all markets that accept a CE Mark. Initial orders for the product have been received.

NeoVista, Inc is planning to begin commercial activity in the US in early 2011 pending Food and Drug Administration (FDA) approval. For more information about the company, or this novel neovascular AMD therapy, please visit the company's Web site at www.neovistainc.com.

###

Read the full story at http://www.prweb.com/releases/Epimacular_Brachytherapy/Neovascular_AMD/prweb3121244.htm.


'/>"/>
Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved

Related medicine news :

1. FDA Grants NeoVistas Request to Utilize Novel Wet AMD Treatment in Compassionate Case
2. NeoVista Presents Anatomic Outcomes of Novel Wet AMD Therapy at 2008 American Society of Retina Specialists Meeting
3. Morehead Presents Webinar on 'A Two-Pronged Strategy to Reduce Nurse Turnover'
4. Orexigen(R) Therapeutics Presents New Data Showing Weight Loss with Contrave Significantly Improves Important Markers of Cardiometabolic Risk
5. YWCA Greater Los Angeles Presents Black & White Benefactrix Ball
6. Hospice Foundation of America Presents Webinar on Grief, Holidays, and Family Dynamics
7. CEL-SCI Presents Data at American College of Rheumatology Conference Which Suggests that CEL-2000 Has Potential to Slow Damage Caused by Rheumatoid Arthritis
8. Formatta Presents Forms-Driven Business Process Optimization Webinar for Healthcare on Wednesday, October 14 at 1 p.m. Eastern
9. Morehead Presents Webinar on "Measuring the Organization's Patient Safety Culture"
10. Simmons Law Firm Presents Second Miles for Meso Walk/Run Fundraiser for Mesothelioma Research
11. Simmons Law Firm Presents Second Miles for Meso Walk/Run Fundraiser
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco dentists, ... cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated to ... breathing. Oral appliances can offer significant relief to about 75 percent of people ...
(Date:10/12/2017)... WAUSAU, Wis. (PRWEB) , ... October 12, 2017 ... ... formulated standard products to meet the demand of today’s consumer and regulatory authorities ... team of probiotic experts and tested to meet the highest standard. , ...
(Date:10/12/2017)... Bethesda, MD (PRWEB) , ... October 12, 2017 , ... ... Award of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s ... 4 – 8. , In honor of Morris F. Collen, a pioneer in the ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... that we intend to develop to enable prevention of a major side effect ... hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare ... Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during ... , The annual award competition recognizes editorial and design excellence across a range of ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... Sept. 22, 2017 AVACEN Medical (AVACEN) announced ... now successfully helping those with the widespread pain associated ... diagnosed Amanda in Essex, England ... my hair, experiencing no sleep at all, tremendous pain, ... I cannot recommend [the AVACEN 100] enough, how this ...
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., ... analytics, today announced that it has been ranked #1 by ... Black Book™ Rankings 2017 User Survey. ZirMed was recognized ... for large hospitals and medical centers over 200 beds and ... Book,s healthcare technology user survey history. ...
(Date:9/18/2017)... PROVIDENCE, R.I. , Sept. 18, 2017 ... in the fields of bioinformatics and immune ... to develop a protective avian influenza A (H7N9) vaccine. ... is distantly related to seasonal influenza and ... approaches, which rely on prior exposure to be ...
Breaking Medicine Technology: