Navigation Links
Nemours researchers uncover new evidence of cancer-causing agent present in gaseous phase of cigarette smoke
Date:3/21/2012

Wilmington, DE A team of researchers led by A. K. Rajasekaran, PhD, Director of the Nemours Center for Childhood Cancer Research, has shown that a key protein involved in cell function and regulation is stopped by a substance present in cigarette smoke. Their work is published online in the American Journal of Physiology - Lung Cell and Molecular Physiology.

Cigarette smoke is well recognized as a cause of lung cancer and is associated with many other forms of cancer in adults. Cigarette smoke has more than 4,000 components, many of which are linked to the development and progression of lung cancer. Evidence has shown secondhand smoke to be as dangerous as primary smoke due to its impact on the cells of the body.

In the study, the authors found a cancer-causing agent called reactive oxygen species (ROS) present in the gaseous phase of cigarette smoke that has the ability to inhibit normal cell function. Exposure to the secondhand smoke produced by as little as two cigarettes was found to almost completely stop the function of a cell's sodium pump within a few hours. In normal cells, the sodium pump plays a critical role transporting potassium into the cell and sodium out of the cell. The competence of the cell's sodium pump, i.e., its inability to regulate sodium, is predictive of cell damage, disease progression and ultimately, survival.

"This is critical information with regard to secondhand smoke," said Dr. Rajasekaran. "We now know that one need not inhale the particulate matter present in secondhand smoke to suffer the consequence of smoking. Exposure to the gaseous substance alone, which you breathe while standing near a smoker, is sufficient to cause harm." Dr. Lee Goodglick, Associate Professor in the Department of Pathology and Laboratory Medicine, UCLA, and co-senior author of the study, noted, "Few reliable lung cancer biomarkers that could predict survival, treatment options or response to therapy exist today. Even fewer have been recognized where the function of the biomarker is known, yielding important information about the mechanism of action. This study really accomplishes both."

This research is the latest finding in the compendium of evidence that supports protecting children from exposure to cigarette smoke. Excessive exposure to cigarette smoke during childhood can facilitate lung cancer development as children grow into adults. While more research is needed to understand the consequences of sodium pump inhibition by cigarette smoke, this study reveals that secondhand smoke is even more dangerous than previously thought.


'/>"/>

Contact: Karen Bengston
kbengsto@nemours.org
302-298-7319
Nemours
Source:Eurekalert

Related medicine news :

1. Nemours Data Show Childhood Overweight and Obesity Leveling Off in Delaware
2. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
3. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
4. Researchers discover new way to kill pediatric brain tumors
5. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
6. Researchers create drug to keep tumor growth switched off
7. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
8. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
9. Clemson researchers develop hands-free texting application
10. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
11. Researchers chart genomic map spanning over 2 dozen cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... February 08, 2016 , ... ... 50% lower incidence rate of type 2 diabetes in the GrassrootsHealth cohort with ... time to make a change in public health,” states Carole Baggerly, Director of ...
(Date:2/8/2016)... Las Vegas, NV (PRWEB) , ... February 08, 2016 , ... ... transformation on February 9th, 10th and 11th, 2016 in honor of his birthday on ... relationships and true happiness. Mahendra Trivedi is known by over 250,000 people from ...
(Date:2/7/2016)... (PRWEB) , ... February 07, 2016 , ... Women's Excellence ... National Wear Red Day. National Wear Red Day is the first Friday each ... Heart disease and stroke cause 1 in 3 deaths among women each year – ...
(Date:2/6/2016)... ... February 06, 2016 , ... US Sports Camps is proud ... . This event brings together top non-profit leaders, ultimate organizations, and coaches from around ... Valerio Iani, Bay Area Disc Program Director of Youth and Education, describes this year ...
(Date:2/5/2016)... ... 2016 , ... Steven Tonkinson, 36, of Coconut Grove, Florida, ran the Miami ... in 2003. This year, he ran all 26.2 miles with a green 25-pound ShelterBox ... Miami Heat. , This Sunday, while many are watching the Superbowl, Steven Tonkinson will ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... HOUSTON , 8. Februar 2016 /PRNewswire/ ... veröffentlichte heute eine Infografik mit dem Titel ... ganzen Welt), mit der der Krankheit gegenüber ... die dazu ermutigen soll, Medikamentenresistenz bei Epilepsie ... der allgemeinen Diskussion zu machen. Mithilfe der ...
(Date:2/5/2016)... Feb. 5, 2016  ivWatch, a medical devices company, is ... Award granted by Governor Terry McAuliffe,s office. ivWatch ... February 25th at an event to be held at the ... award honors professionals and business that have made significant contributions ... Logo - http://photos.prnewswire.com/prnh/20160205/330117LOGO ...
(Date:2/5/2016)... -- Aethlon Medical, Inc. (Nasdaq: AEMD ), today announced ... presenting at Source Capital Group,s 2016 Disruptive Growth & Healthcare ... 2:15 p.m. ET on Wednesday, February 10, 2016.  Mr. Joyce ... at 3:15 p.m. ET. http://www.aethlonmedical.com .  The webcast ... conclusion of the live event. The panel discussion will not ...
Breaking Medicine Technology: