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Nemours Center for Childhood Cancer Research Receives Over $1 Million in Grants for Cancer Research in 2008
Date:1/8/2009

pidly growing cells, promising a new kind of treatment for this cancer that will be less harmful to normal tissues in children. In this new project, Dr. Mason's team will learn how this compound causes death of the cancer cells so that Nemours can collaborate with pharmaceutical companies to make better drugs to treat this childhood cancer.

Anders E. Kolb, MD, received a one year $50,000 grant from the FOSTER Foundation to study Insulin-like growth factor receptor (IGF-1R) inhibitors in osteosarcoma, a common bone cancer in children. Inhibitors of IGF-1R have shown promising early results in clinical trials in patients with osteosarcoma. In this proposal, Dr. Kolb will evaluate gene expression changes in osteosarcoma tumors sensitive and resistant to IGF-1R inhibition. An understanding of the cellular events that occur after IGF-1R inhibition will help identify rational therapeutic combinations with other targeted agents; identify markers of response; and provide valuable information about osteosarcoma biology.

About the Nemours Center for Childhood Cancer Research
The Nemours Center for Childhood Cancer Research is a newly established research entity of Nemours Biomedical Research at the Alfred I. duPont hospital for children. The NCCCR is located in a fully renovated laboratory space in 1701 Rockland Road, Wilmington, DE. The goal of the center is to evolve into a leader in research focusing on biomarkers for childhood cancers and cancers that affect families. The NCCCR will closely work together with Helen F. Graham Cancer Center, University of Delaware, Center for Translational Research and the Delaware Biotechnology Institute. The Alfred I. duPont Hospital for Children is a division of N
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